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5-N-acetyl-L-ornithine + 2-oxoglutarate
5-(N-acetylamino)-2-oxopentanoate + L-glutamate
-
4.0% of the activity with L-lysine
-
-
?
6-N-acetyl-L-lysine + 2-oxoglutarate
6-(N-acetylamino)-2-oxohexanoate + L-glutamate
-
5.7% of the activity with L-lysine
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
very slow
-
-
?
L-lysine + 2-oxoadipate
2-aminoadipate 6-semialdehyde + L-homoglutarate
-
7% of the activity with 2-oxoglutarate
-
-
?
L-lysine + 2-oxobutanoate
2-aminoadipate 6-semialdehyde + 2-aminobutanoate
L-lysine + 2-oxoglutarate
(S)-2-amino-6-oxohexanoate + L-glutamate
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + 1-piperideine-6-carboxylic acid + L-glutamate
Q5XPV2
-
product 2-aminoadipate 6-semialdehyde is further transformed to 1-piperideine-6-carboxylic acid, which may react with methylglyoxal to generate the acylated N-heterocyclic odorant 2-acetyltetrahydropyridine
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + ?
Q5XPV2
-
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
L-lysine + 2-oxohexanoate
2-aminoadipate 6-semialdehyde + 2-aminohexanoate
-
8.7% of the activity with 2-oxoglutarate
-
-
?
L-lysine + 2-oxopentanoate
2-aminoadipate 6-semialdehyde + 2-aminopentanoate
L-lysine + oxaloacetate
2-aminoadipate 6-semialdehyde + L-aspartate
L-lysine + pyruvate
2-aminoadipate 6-semialdehyde + L-alanine
L-lysine hydroxamate + 2-oxoglutarate
? + L-glutamate
-
5.1% of the activity with L-lysine
-
-
?
L-ornithine + 2-oxoglutarate
5-hydroxy-L-proline + glutamate
L-ornithine + 2-oxoglutarate
? + L-glutamate
L-thialysine + 2-oxoglutarate
? + L-glutamate
-
13% of the activity with L-lysine
-
-
?
N-alpha-benzyloxycarbonyl-L-ornithine + 2-oxoglutarate
N-benzyloxycarbonyl-5-hydroxy-L-proline + glutamate
N-alpha-tert-butoxycarbonyl-L-ornithine + 2-oxoglutarate
N-tert-butoxycarbonyl-5-hydroxy-L-proline + glutamate
S-(2-aminoethyl)-L-cysteine + 2-oxoglutarate
? + L-glutamate
S-(2-N-acetylaminoethyl)-L-cysteine + 2-oxoglutarate
S-(2-N-acetylaminoethyl)-2-oxopropanoic acid + L-glutamate
-
3.3% of the activity with L-lysine
-
-
?
additional information
?
-
L-lysine + 2-oxobutanoate
2-aminoadipate 6-semialdehyde + 2-aminobutanoate
-
0.46% of the activity with 2-oxoglutarate
-
-
?
L-lysine + 2-oxobutanoate
2-aminoadipate 6-semialdehyde + 2-aminobutanoate
-
5.0% of the activity with 2-oxoglutarate
-
-
?
L-lysine + 2-oxoglutarate
(S)-2-amino-6-oxohexanoate + L-glutamate
-
-
-
?
L-lysine + 2-oxoglutarate
(S)-2-amino-6-oxohexanoate + L-glutamate
-
-
-
?
L-lysine + 2-oxoglutarate
(S)-2-amino-6-oxohexanoate + L-glutamate
-
-
-
?
L-lysine + 2-oxoglutarate
(S)-2-amino-6-oxohexanoate + L-glutamate
-
-
-
?
L-lysine + 2-oxoglutarate
(S)-2-amino-6-oxohexanoate + L-glutamate
-
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
Flavobacterium fuscum
-
-
the product allysine is converted into the intramolecularly dehydrated form 1-piperideine 6-carboxylate
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
Flavobacterium fuscum
-
first step of metabolism of lysine
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
-
r
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
r
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
-
r
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
r
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
first step in biosynthesis of cephalosporins, response of activity to carbon source
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
time profile of enzyme activity
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
study of temporal and spatial distribution of enzyme
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
time profile of enzyme activity
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
-
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
the product allysine is converted into the intramolecularly dehydrated form 1-piperideine 6-carboxylate
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
-
the product allysine is converted into the intramolecularly dehydrated form 1-piperideine 6-carboxylate
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
2-oxoglutarate is the only active amino acceptor
-
?
L-lysine + 2-oxoglutarate
2-aminoadipate 6-semialdehyde + L-glutamate
-
involved in production of L-pipecolic acid
-
-
?
L-lysine + 2-oxopentanoate
2-aminoadipate 6-semialdehyde + 2-aminopentanoate
-
0.46% of the activity with 2-oxoglutarate
-
-
?
L-lysine + 2-oxopentanoate
2-aminoadipate 6-semialdehyde + 2-aminopentanoate
-
5.3% of the activity with 2-oxoglutarate
-
-
?
L-lysine + oxaloacetate
2-aminoadipate 6-semialdehyde + L-aspartate
-
38% of the activity with 2-oxoglutarate
-
-
?
L-lysine + oxaloacetate
2-aminoadipate 6-semialdehyde + L-aspartate
-
with very low efficiency
-
-
?
L-lysine + oxaloacetate
2-aminoadipate 6-semialdehyde + L-aspartate
-
0.46% of the activity with 2-oxoglutarate
-
-
?
L-lysine + oxaloacetate
2-aminoadipate 6-semialdehyde + L-aspartate
-
5.3% of the activity with 2-oxoglutarate
-
-
?
L-lysine + pyruvate
2-aminoadipate 6-semialdehyde + L-alanine
-
19% of the activity with 2-oxoglutarate
-
-
?
L-lysine + pyruvate
2-aminoadipate 6-semialdehyde + L-alanine
-
with very low efficiency
-
-
?
L-lysine + pyruvate
2-aminoadipate 6-semialdehyde + L-alanine
-
4.7% of the activity with 2-oxoglutarate
-
-
?
L-ornithine + 2-oxoglutarate
5-hydroxy-L-proline + glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
5-hydroxy-L-proline + glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
? + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
? + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
? + L-glutamate
-
55% of the activity with L-lysine
-
-
?
N-alpha-benzyloxycarbonyl-L-ornithine + 2-oxoglutarate
N-benzyloxycarbonyl-5-hydroxy-L-proline + glutamate
-
-
-
-
?
N-alpha-benzyloxycarbonyl-L-ornithine + 2-oxoglutarate
N-benzyloxycarbonyl-5-hydroxy-L-proline + glutamate
-
-
-
-
?
N-alpha-tert-butoxycarbonyl-L-ornithine + 2-oxoglutarate
N-tert-butoxycarbonyl-5-hydroxy-L-proline + glutamate
-
-
-
-
?
N-alpha-tert-butoxycarbonyl-L-ornithine + 2-oxoglutarate
N-tert-butoxycarbonyl-5-hydroxy-L-proline + glutamate
-
-
-
-
?
S-(2-aminoethyl)-L-cysteine + 2-oxoglutarate
? + L-glutamate
-
16% of the activity with L-lysine
-
-
?
S-(2-aminoethyl)-L-cysteine + 2-oxoglutarate
? + L-glutamate
-
-
-
-
?
additional information
?
-
no substrate: L-ornithine
-
-
?
additional information
?
-
no substrate: L-ornithine
-
-
?
additional information
?
-
-
lysine is substrate and inducer of the enzyme
-
-
?
additional information
?
-
-
the enzyme is responsible for the formation of 1-piperideine-6-carboxylic acid, which may react with methylglyoxal to generate the acylated N-heterocyclic odorant 2-acetyltetrahydropyridine
-
-
?
additional information
?
-
Q5XPV2
the enzyme is responsible for the formation of 1-piperideine-6-carboxylic acid, which may react with methylglyoxal to generate the acylated N-heterocyclic odorant 2-acetyltetrahydropyridine
-
-
?
additional information
?
-
-
no substrate: D-lysine, 2-N-acetyl-L-lysine, 2-N-acetyl-L-ornithine, S-(2-aminoethyl)alpha-L-cysteine
-
-
?
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(E)-2-(2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid
-
(E)-2-(4-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-indol-3-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-pyrrol -2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(2,4-dihydroxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-benzyloxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-fluorophenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrofuran-2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(furan-2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile
-
(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid
-
(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid
-
(E)-3-(benzo[d][1,3]dioxol-5-yl)-2-(benzo[d]thiazol-2-yl)acrylonitrile
-
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid
-
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid
-
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)isophthalic acid
-
(E)-5-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)isophthalic acid
-
2,2'-oxybis[N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide]
25.6% cytotoxicity at 0.1 mM
2,2'-oxybis[N'-[(E)-[(3-benzyloxy)phenyl]methylidene]acetohydrazide]
26.4% cytotoxicity at 0.1 mM
2-oxopentanedioic acid
binding energy 6.48 kcal per mol
2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid
-
2-[methyl[(1-methylpiperidin-2-yl)methyl]amino]-1-phenylethanol
binding energy 7.23 kcal per mol
4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide
protein is stabilzed in presence of the inhibitor
4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid
at 0.05 mM, 24.87% cytotoxicity in a HEK-293 cell line
acetate
-
stimulates alanine transamination, inhibits lysine transamination
Br-
-
stimulates alanine transamination, inhibits lysine transamination
Cl-
-
stimulates alanine transamination, inhibits lysine transamination
F-
-
stimulates alanine transamination, inhibits lysine transamination
formate
-
stimulates alanine transamination, inhibits lysine transamination
I-
-
stimulates alanine transamination, inhibits lysine transamination
N-([2-[2-(3,4-dimethoxyphenyl)ethyl]-1,3-dioxo-2,3,5,6,11,11a-hexahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indol-5-yl]methyl)-2-(4-methoxyphenyl)acetamide
binding energy 10.79 kcal per mol
O-(2-aminoethyl)-DL serine
-
-
Phenylglyoxal
-
loss of activity with lysine, no effect on activity with L-alanine
propionate
-
inhibits alanine transamination and lysine transamination
additional information
identification of inhibitors by high throughput virtual database screening for active derivatives using a benzothiazole lead as template, structure-activity relationship analysis of potentials inhibitors, docking study, overview
-
additional information
-
incubation of the enzyme with L-lysine in the presence of high concentrations of phosphate gives an inactive form of the enzyme (semiapoenzyme), reactivation with pyridoxal 5'-phosphate
-
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0.05378
(E)-2-(2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00308
(E)-2-(4-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.03791
(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-indol-3-yl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.01705
(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-pyrrol -2-yl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.02319
(E)-2-(benzo[d]thiazol-2-yl)-3-(2,4-dihydroxyphenyl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.06489
(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.06141
(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.04793
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-benzyloxyphenyl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00411
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-fluorophenyl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00783
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.01038
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxyphenyl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.01959
(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrofuran-2-yl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.05476
(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.01623
(E)-2-(benzo[d]thiazol-2-yl)-3-(furan-2-yl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.09257
(E)-2-(benzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00374
(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00573
(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.06598
(E)-3-(benzo[d][1,3]dioxol-5-yl)-2-(benzo[d]thiazol-2-yl)acrylonitrile
Mycobacterium tuberculosis
pH 7.2, 37°C
0.01406
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00672
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00262
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)isophthalic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00115
(E)-5-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)isophthalic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.00081
2,2'-oxybis[N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide]
Mycobacterium tuberculosis
pH not specified in the publication, temperature not specified in the publication
0.0019
2,2'-oxybis[N'-[(E)-[(3-benzyloxy)phenyl]methylidene]acetohydrazide]
Mycobacterium tuberculosis
pH not specified in the publication, temperature not specified in the publication
0.0018
2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
0.0017
4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide
Mycobacterium tuberculosis
pH 7.2, 37°C
0.0012
4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid
Mycobacterium tuberculosis
pH 7.2, 37°C
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Fujii, T.; Mukaihara, M.; Agematu, H.; Tsunekawa, H.
Biotransformation of L-lysine to L-pipecolic acid catalyzed by L-lysine 6-aminotransferase and pyrroline-5-carboxylate reductase
Biosci. Biotechnol. Biochem.
66
622-627
2002
[Flavobacterium] lutescens
brenda
Soda, K.; Misono, H.; Yamamoto, T.
L-Lysine:alpha-ketoglutarate aminotransferase. I. Identification of a product, delta-1-piperideine-6-carboxylic acid
Biochemistry
7
4102-4109
1968
Flavobacterium fuscum
brenda
Soda, K.; Misono, H.
L-Lysine:alpha-ketoglutarate aminotransferase. II. Purification, crystallization, and properties
Biochemistry
7
4110-4119
1968
[Flavobacterium] lutescens
brenda
Soda, K.; Misono, H.
L-Lysine-ketoglutarate aminotransferase (Acetobacter liquidum)
Methods Enzymol.
17B
222-228
1971
[Flavobacterium] lutescens
-
brenda
Tanizawa, K.; Yoshimura, T.; Soda, K.
L-Lysine transaminase from Flavobacterium lutescens
Methods Enzymol.
113
96-102
1985
[Flavobacterium] lutescens
brenda
Yoshimura, T.; Tanizawa, K.; Tanaka, H.; Soda, K.
The effect of carboxylates and halides on L-lysine 6-aminotransferase-catalyzed reactions
J. Biochem.
95
559-565
1984
[Flavobacterium] lutescens
brenda
Yagi, T.; Misono, H.; Kurihara, N.; Yamamoto, T.; Soda, K.
L-Lysine: 2-oxoglutarate 6-aminotransferase. Subunit structure composed of non-identical polypeptides and pyridoxal 5-phosphate-binding subunit
J. Biochem.
87
1395-1402
1980
[Flavobacterium] lutescens
brenda
Yagi, T.; Yamamoto, T.; Soda, K.
A novel purification procedure of L-lysine 6-aminotransferase from Flavobacterium lutescence
Biochim. Biophys. Acta
614
63-70
1980
[Flavobacterium] lutescens
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