2.5.1.48: cystathionine gamma-synthase
This is an abbreviated version!
For detailed information about cystathionine gamma-synthase, go to the full flat file.
Word Map on EC 2.5.1.48
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2.5.1.48
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homocystinuria
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transsulfuration
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beta-lyase
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gamma-lyase
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sulfhydrylase
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o-acetylhomoserine
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gamma-replacement
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l-cystathionine
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cystathionase
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o-phosphohomoserine
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paucicostata
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gamma-elimination
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homocystine
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s-methylmethionine
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remethylation
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synthesis
- 2.5.1.48
- homocystinuria
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transsulfuration
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beta-lyase
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gamma-lyase
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sulfhydrylase
- o-acetylhomoserine
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gamma-replacement
- l-cystathionine
- cystathionase
- o-phosphohomoserine
- paucicostata
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gamma-elimination
- homocystine
- s-methylmethionine
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remethylation
- synthesis
Reaction
Synonyms
AtCGS, CGS, CGS1, CS,26, cystathionine gamma-synthase, cystathionine synthase, cystathionine synthetase, cystathionine-gamma-synthase, EC 4.2.99.9, homoserine O-transsuccinylase, homoserine transsuccinylase, HTS, MetB, O-succinyl-L-homoserine succinate-lyase (adding cysteine), O-succinylhomoserine (Thiol)-lyase, O-succinylhomoserine synthase, O-succinylhomoserine synthetase, synthase, cystathionine gamma-
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.5.1.48 - cystathionine gamma-synthase
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REACTION DIAGRAM
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
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first step in conversion of selenocysteine to volatile dimethylselenide
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L-cystathionine + succinate
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
constitutive overexpression of the enzyme in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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key enzyme of Met biosynthesis
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
enzyme catalyzes the first step in methionine biosynthesis, overview
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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the second enzyme of the methionine biosynthetic pathway
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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key intermediate in transsulfuration pathways
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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first step in bacterial transsulfuration pathway
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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methionine biosynthesis
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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the enzyme catalyzes the first reaction specific for methionine biosynthesis
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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essential step in bacterial methionine biosynthesis
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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the expression of the enzyme is light-inducible
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O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
the enzyme catalyzes a near-equilibrium reaction and does not display features of a pathway-regulating enzyme
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L-cystathionine + succinate
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O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
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S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the CGS1 gene
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additional information
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S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the CGS1 gene
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additional information
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the enzyme might by rate-limiting in selenium volatilization
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