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2.5.1.48: cystathionine gamma-synthase

This is an abbreviated version!
For detailed information about cystathionine gamma-synthase, go to the full flat file.

Word Map on EC 2.5.1.48

Reaction

O4-succinyl-L-homoserine
+
L-cysteine
=
L-cystathionine
+
succinate

Synonyms

AtCGS, CGS, CGS1, CS,26, cystathionine gamma-synthase, cystathionine synthase, cystathionine synthetase, cystathionine-gamma-synthase, EC 4.2.99.9, homoserine O-transsuccinylase, homoserine transsuccinylase, HTS, MetB, O-succinyl-L-homoserine succinate-lyase (adding cysteine), O-succinylhomoserine (Thiol)-lyase, O-succinylhomoserine synthase, O-succinylhomoserine synthetase, synthase, cystathionine gamma-

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.48 cystathionine gamma-synthase

Inhibitors

Inhibitors on EC 2.5.1.48 - cystathionine gamma-synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1S,3aS,4R,6aR)-1,4-bis(1,3-benzodioxol-5-yl)hexahydropentalen-3a(1H)-ol
i.e. paulownin, NPLC604, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 15 mg/ml
(1S,3aS,4S,6aS)-1,4-di(3,4,5-trimethoxy)-phenyloctahydropentalene
i.e. yangambin, NPLC605, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 10 mg/ml
(Z)-3-(2-phosphonethen-1-yl)pyridine-2-carboxylic acid
-
Ki: 0.04 mM
(Z)-3-(2-phosphonoethen-1-yl)pyridine-2-carboxylic acid
-
-
2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
i.e. alpha-lapachone, NPLC518, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 2.6 mg/ml
3-(phosphonomethyl)pyridine-2-carboxylic acid
-
-
3-Methyl-2-benzothiazolinone hydrazone
-
-
4-(phosphonomethyl)pyridine-2-carboxylic acid
6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
i.e. 9-hydroxy-alpha-lapachone, NPLC519, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 2.5 mg/ml
aminooxyacetic acid
-
-
beta-mercaptopropionate
chloromercuriphenylsulfonate
-
inhibition of gamma-elimination
cystathionine
-
competitive, gamma-elimination
D-cycloserine
-
-
D-cysteine
-
inhibition of gamma-elimination
dithiothreitol
-
10% inhibition of beta-elimination from O-succinyl-L-serine
DL-(E)-2-amino-5-phosphono-3-pentenoic acid
DL-propargylglycine
-
irreversible
hydroxylamine
L-cysteine
L-homocysteine
L-methionine
-
2 mM, decreases the expression level of CGS
N-ethylmaleimide
-
inhibition of gamma-elimination
phenylhydrazine
-
-
propargylglycine
S-adenosyl-L-homocysteine
-
-
S-adenosyl-L-methionine
Semicarbazide
-
-
additional information
-