2.5.1.48: cystathionine gamma-synthase
This is an abbreviated version!
For detailed information about cystathionine gamma-synthase, go to the full flat file.
Word Map on EC 2.5.1.48
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2.5.1.48
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homocystinuria
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transsulfuration
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beta-lyase
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gamma-lyase
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sulfhydrylase
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o-acetylhomoserine
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gamma-replacement
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l-cystathionine
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cystathionase
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o-phosphohomoserine
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paucicostata
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gamma-elimination
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homocystine
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s-methylmethionine
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remethylation
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synthesis
- 2.5.1.48
- homocystinuria
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transsulfuration
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beta-lyase
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gamma-lyase
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sulfhydrylase
- o-acetylhomoserine
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gamma-replacement
- l-cystathionine
- cystathionase
- o-phosphohomoserine
- paucicostata
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gamma-elimination
- homocystine
- s-methylmethionine
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remethylation
- synthesis
Reaction
Synonyms
AtCGS, CGS, CGS1, CS,26, cystathionine gamma-synthase, cystathionine synthase, cystathionine synthetase, cystathionine-gamma-synthase, EC 4.2.99.9, homoserine O-transsuccinylase, homoserine transsuccinylase, HTS, MetB, O-succinyl-L-homoserine succinate-lyase (adding cysteine), O-succinylhomoserine (Thiol)-lyase, O-succinylhomoserine synthase, O-succinylhomoserine synthetase, synthase, cystathionine gamma-
ECTree
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Inhibitors
Inhibitors on EC 2.5.1.48 - cystathionine gamma-synthase
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(1S,3aS,4R,6aR)-1,4-bis(1,3-benzodioxol-5-yl)hexahydropentalen-3a(1H)-ol
i.e. paulownin, NPLC604, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 15 mg/ml
(1S,3aS,4S,6aS)-1,4-di(3,4,5-trimethoxy)-phenyloctahydropentalene
i.e. yangambin, NPLC605, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 10 mg/ml
2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
i.e. alpha-lapachone, NPLC518, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 2.6 mg/ml
6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
i.e. 9-hydroxy-alpha-lapachone, NPLC519, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 2.5 mg/ml
chloromercuriphenylsulfonate
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inhibition of gamma-elimination
cystathionine
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competitive, gamma-elimination
D-cysteine
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inhibition of gamma-elimination
dithiothreitol
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10% inhibition of beta-elimination from O-succinyl-L-serine
N-ethylmaleimide
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inhibition of gamma-elimination
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competitive inhibitor of gamma-replacement reaction
beta-mercaptopropionate
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also a substrate for gamma-replacement reaction
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complete inhibition of gamma-elimination and beta-elimination
L-cysteine
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inhibition of beta-elimination
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partial inhibition of beta-elimination and gamma-elimination
propargylglycine
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i.e. 2-amino-4-pentynoate
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0.003 mM, 34% inhibition , 0.1 mM, 96% inhibition, physiological inhibitor
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not inhibited by p-chloromercuribenzoate, iodoacetate, N-ethylmaleimide, 5,5'-dithiobis(2-nitrobenzoate), NaCN
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additional information
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no inhibition by 2-amino-1-hydroxycyclobutane-1-acetic acid
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