2.5.1.48: cystathionine gamma-synthase

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For detailed information about cystathionine gamma-synthase, go to the full flat file.

Reaction

Synonyms

AtCGS, CGS, CGS1, CS,26, cystathionine gamma-synthase, cystathionine synthase, cystathionine synthetase, cystathionine-gamma-synthase, EC 4.2.99.9, homoserine O-transsuccinylase, homoserine transsuccinylase, HTS, MetB, O-succinyl-L-homoserine succinate-lyase (adding cysteine), O-succinylhomoserine (Thiol)-lyase, O-succinylhomoserine synthase, O-succinylhomoserine synthetase, synthase, cystathionine gamma-

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.48 cystathionine gamma-synthase

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Results	in table
1	Activating Compound
10492	AA Sequence
5	Application
1	CAS Registry Number
20	Cloned(Commentary)
17	Cofactor
9	Crystallization (Commentary)
2	General Information
1	General Stability
4	IC50 Value
41	Inhibitors
40	kcat/KM [mM/s]
14	Ki Value [mM]
76	KM Value [mM]
2	Localization
20	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
93	Organism
10	Pathway
40	PDB ID
10	pH Optimum
2	pH Range
2	Posttranslational Modification
26	Protein Variants
14	Purification (Commentary)
5	Reaction
2	Reaction Type
81	Reference
1	Renatured (Commentary)
21	Source Tissue
14	Specific Activity [micromol/min/mg]
3	Storage Stability
166	Substrates and Products (Substrate)
13	Subunits
34	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
35	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.5.1.48 - cystathionine gamma-synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.019

(1S,3aS,4R,6aR)-1,4-bis(1,3-benzodioxol-5-yl)hexahydropentalen-3a(1H)-ol

Helicobacter pylori

Q1M0P5

25°C, pH 9.0

687456

0.027

(1S,3aS,4S,6aS)-1,4-di(3,4,5-trimethoxy)-phenyloctahydropentalene

Helicobacter pylori

Q1M0P5

25°C, pH 9.0

687456

0.011

2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Helicobacter pylori

Q1M0P5

25°C, pH 9.0

687456

0.009

6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Helicobacter pylori

Q1M0P5

25°C, pH 9.0

687456