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L-cystathionine + acetate
O-acetyl-L-homoserine + L-cysteine
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutyrate
-
beta-elimination
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
L-cystathionine + L-cysteine
L-cystathionine + L-cysteine
-
-
observed via 35S-exchange
?
O-acetyl-L-homoserine + 2-mercaptoethanol
S-hydroxyethyl-L-homocysteine + acetate
-
150% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine + acetate
-
50% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine + acetate
-
65% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + allyl mercaptan
S-allyl-L-homocysteine + acetate
-
4% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + benzyl mercaptan
S-benzyl-L-homocysteine + acetate
-
41% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + CH3SH
L-methionine + acetate
-
11% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + D-Cys
D-allocystathionine + acetate
-
101% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + D-homocysteine
meso-homolanthionine + acetate
-
125% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + ethyl mercaptan
L-thionine + acetate
-
24% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + isobutyl mercaptan
S-isobutyl-L-homocysteine + acetate
-
13% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + isopropyl mercaptan
S-isopropyl-L-homocysteine + acetate
-
1% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + L-Cys ethyl ester
S-[(2R)-2-amino-3-ethoxy-3-oxopropyl]-L-homocysteine + acetate
-
15% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. L-cystathionine monoethyl ester + acetate
?
O-acetyl-L-homoserine + L-Cys methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + acetate
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
O-acetyl-L-homoserine + L-homocysteine
L-homolanthionine + acetate
-
92% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + m-thiocresol
S-m-tolyl-L-homocysteine + acetate
-
150% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + N-acetyl-L-Cys
S-(L-acetylamino-2-carboxyethyl)-L-homocysteine + acetate
-
12% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. mono-N-acetyl-L-cystathionine + acetate
?
O-acetyl-L-homoserine + n-butyl mercaptan
S-n-butyl-L-homocysteine + acetate
-
5% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + n-propyl mercaptan
S-n-propyl-L-homocysteine + acetate
-
13% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + o-thiocresol
S-o-tolyl-L-homocysteine + acetate
-
3% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + p-nitrothiophenol
S-p-nitrophenyl-L-homocysteine + acetate
-
41% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + p-thiocresol
S-p-tolyl-L-homocysteine + acetate
-
25% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + phenyl mercaptan
S-phenyl-L-homocysteine + acetate
-
98% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + S2-
L-homocysteine + acetate
-
163% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + sec-butyl mercaptan
S-sec-butyl-L-homocysteine + acetate
-
5% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + tert-butyl mercaptan
S-tert-butyl-L-homosysteine + acetate
-
2% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioacetic acid
S-acetyl-L-homocysteine + acetate
-
3% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioglycolate ethyl ester
S-ethoxycarbonyl-L-homocysteine + acetate
-
348% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioglycolate n-butyl ester
S-n-butoxycarbonyl-L-homocysteine + acetate
-
274% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thiosalicylic acid
S-o-carboxyphenyl-L-homocysteine + acetate
-
63% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-malonyl-L-homoserine + L-cysteine
L-cystathionine + malonate
-
14% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-phenyl-L-homoserine + L-cysteine
L-cystathionine + phenol
-
1% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
O-phospho-L-homoserine + L-cysteine ethyl ester
S-[(2R)-2-amino-3-ethoxy-3-oxopropyl]-L-homocysteine + phosphate
-
1% relative activity to O-phospho-L-homoserine + L-cysteine
-
-
?
O-phospho-L-homoserine + L-cysteine methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + phosphate
-
15% relative activity to O-phospho-L-homoserine + L-cysteine
-
-
?
O-phospho-L-homoserine + L-selenocysteine
selenocystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + S2-
L-homocysteine + phosphate
O-phospho-L-serine + L-cysteine
?
-
-
-
-
?
O-succinyl-L-homoserine
succinate + pyruvate + NH3
-
elimination reaction
-
-
?
O-succinyl-L-homoserine + 2-mercaptoethanol
S-ethyl-L-homocysteine + succinate
-
32% of the activity with L-cysteine
-
-
?
O-succinyl-L-homoserine + beta-mercaptopropionate
S-carboxyethyl-L-homocysteine + succinate
-
-
-
?
O-succinyl-L-homoserine + CH3SH
L-methionine + succinate
O-succinyl-L-homoserine + D-cysteine
?
-
20% of the activity with L-cysteine
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
O-succinyl-L-homoserine + sodium sulfide
L-homocysteine + sodium succinate
-
62% of the activity with L-cysteine
-
-
?
O-succinyl-L-serine + H2O
succinate + pyruvate + NH3
O-succinyl-L-serine + L-cysteine
lanthionine + succinate
-
-
-
?
O-succinyl-L-serine + L-homocysteine
succinate + L-cystathionine
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
additional information
?
-
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
beta-elimination
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
-
-
-
?
O-acetyl-L-homoserine + L-Cys methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + acetate
-
20% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. L-cystathionine monomethyl ester + acetate
?
O-acetyl-L-homoserine + L-Cys methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + acetate
-
26% of the activity with L-Cys
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
gamma-replacement
-
-
r
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
gamma-replacement
-
?
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
-
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
Neptunia amplexicaulis
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
-
-
-
?
O-phospho-L-homoserine + S2-
L-homocysteine + phosphate
-
-
-
-
?
O-phospho-L-homoserine + S2-
L-homocysteine + phosphate
-
13% relative activity to O-phospho-L-homoserine + L-cysteine
-
?
O-succinyl-L-homoserine + CH3SH
L-methionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + CH3SH
L-methionine + succinate
-
-
-
?
O-succinyl-L-homoserine + CH3SH
L-methionine + succinate
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination, in absence of L-cysteine
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
-
gamma-elimination, in absence of L-cysteine
-
-
?
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
-
-
-
?
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
constitutive overexpression of the enzyme in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
key enzyme of Met biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
enzyme catalyzes the first step in methionine biosynthesis, overview
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the second enzyme of the methionine biosynthetic pathway
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
key intermediate in transsulfuration pathways
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
first step in bacterial transsulfuration pathway
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
replacement reaction
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the enzyme catalyzes the first reaction specific for methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
Pseudomonas dacunhae
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
essential step in bacterial methionine biosynthesis
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
the expression of the enzyme is light-inducible
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
the enzyme catalyzes a near-equilibrium reaction and does not display features of a pathway-regulating enzyme
-
-
?
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
-
-
-
-
?
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
-
first step in conversion of selenocysteine to volatile dimethylselenide
-
-
?
O-succinyl-L-serine + H2O
succinate + pyruvate + NH3
-
beta-elimination
-
?
O-succinyl-L-serine + H2O
succinate + pyruvate + NH3
-
beta-elimination
-
?
O-succinyl-L-serine + L-homocysteine
succinate + L-cystathionine
-
beta-replacement, very low reaction rate
-
?
O-succinyl-L-serine + L-homocysteine
succinate + L-cystathionine
-
beta-replacement, very low reaction rate
-
?
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
-
-
-
-
?
additional information
?
-
S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the CGS1 gene
-
-
?
additional information
?
-
-
S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the CGS1 gene
-
-
?
additional information
?
-
-
the enzyme might by rate-limiting in selenium volatilization
-
-
?
additional information
?
-
-
catalyzes alpha or beta proton exchange with a number of amino acids and L-allylglycine
-
-
?
additional information
?
-
-
enzyme performs an elimination or a replacement reaction
-
-
?
additional information
?
-
-
beta-elimination and gamma-elimination barely catalyzed
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
exchange of tritium from water into both alpha and beta positions of a wide variety of amino acids which are otherwise no substrates
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2.6
2-mercaptoethanol
-
-
100
CH3SH
-
pH 7.3, 30°C, gamma-replacement reaction
3
H2S
-
pH 7.3, 30°C, gamma-replacement reaction
0.11 - 2.4
L-cystathionine
0.89
L-cysteine methyl ester
-
-
0.07
L-selenocysteine
-
-
64.5
O-acetyl-L-homoserine
1.4 - 7.1
O-phospho-L-homoserine
2.85
O-phospho-L-serine
-
-
0.05 - 90
O-succinyl-L-homoserine
0.7 - 1.2
O-Succinyl-L-serine
additional information
additional information
-
0.11
L-cystathionine
-
wild-type, 25°C, pH 7.8
0.26
L-cystathionine
-
mutant E325Y 25°C, pH 7.8
2.4
L-cystathionine
-
mutant D45F, 25°C, pH 7.8
0.1
L-cysteine
-
pH 7.8, 25°C, replacement reaction, ordered mechanism
0.11
L-cysteine
-
pH 7.8, 25°C, replacement reaction, modified ping-pong mechanism
0.12
L-cysteine
-
mutant R49A, pH 7.8, 25°C
0.15
L-cysteine
-
mutant Y101F, pH 7.8, 25°C
0.17
L-cysteine
-
mutant E325A, pH 7.8, 25°C
0.18
L-cysteine
-
pH 7.5, 30°C
0.2
L-cysteine
-
mutant S326A, pH 7.8, 25°C
0.22
L-cysteine
-
mutant R361K, pH 7.8, 25°C
0.22
L-cysteine
-
mutant R48K, pH 7.8, 25°C
0.24
L-cysteine
-
wild-type, pH 7.8, 25°C
0.29
L-cysteine
-
mutant E325Q, pH 7.8, 25°C
0.3
L-cysteine
-
mutant N227A, pH 7.8, 25°C
0.36
L-cysteine
-
mutant R49K, pH 7.8, 25°C
0.5
L-cysteine
-
pH 7.5, 37°C
0.6
L-cysteine
-
mutant Y46F, pH 7.8, 25°C
0.65
L-cysteine
-
mutant R106K, pH 7.8, 25°C
0.8
L-cysteine
-
mutant D45A, pH 7.8, 25°C
0.9
L-cysteine
-
mutant D45N, pH 7.8, 25°C
3
L-cysteine
-
mutant R106A, pH 7.8, 25°C
64.5
O-acetyl-L-homoserine
-
-
64.5
O-acetyl-L-homoserine
-
-
1.4
O-phospho-L-homoserine
-
pH 7.5, 30°C
3.6
O-phospho-L-homoserine
-
pH 7.5, 37°C
7.1
O-phospho-L-homoserine
-
-
0.05
O-succinyl-L-homoserine
-
pH 7.3, 30°C, reaction with H2S
0.07
O-succinyl-L-homoserine
-
pH 7.3, 30°C, gamma-replacement reaction
0.3
O-succinyl-L-homoserine
-
pH 7.3, 30°C, gamma-elimination reaction
0.32
O-succinyl-L-homoserine
-
pH 7.5, 30°C
0.33
O-succinyl-L-homoserine
-
pH 8.2, 25°C, gamma-elimination reaction
0.7
O-succinyl-L-homoserine
-
mutant E325A, pH 7.8, 25°C
1.1
O-succinyl-L-homoserine
-
mutant E325Q, pH 7.8, 25°C
1.2
O-succinyl-L-homoserine
-
pH 7.8, 25°C, replacement reaction, ordered mechanism
1.3
O-succinyl-L-homoserine
-
pH 7.8, 25°C, elimination reaction, modified ping-pong mechanism
1.3
O-succinyl-L-homoserine
-
wild-type, gamma-elimination, 25°C, pH 7.8
1.5
O-succinyl-L-homoserine
-
mutant D45F/E325Y, gamma-elimination, 25°C, pH 7.8
1.7
O-succinyl-L-homoserine
-
mutant E325Y, gamma-elimination, 25°C, pH 7.8
1.8
O-succinyl-L-homoserine
-
mutant R48K, pH 7.8, 25°C
1.9
O-succinyl-L-homoserine
-
mutant Y101F, pH 7.8, 25°C
2
O-succinyl-L-homoserine
-
mutant D45F, gamma-elimination, 25°C, pH 7.8
2.1
O-succinyl-L-homoserine
-
mutant E325Y, gamma-replacement, 25°C, pH 7.8
2.5
O-succinyl-L-homoserine
-
pH 7.8, 25°C, replacement reaction, modified ping-pong mechanism
2.5
O-succinyl-L-homoserine
-
wild-type, gamma-replacement, 25°C, pH 7.8
3.02
O-succinyl-L-homoserine
25°C, pH 9.0
4
O-succinyl-L-homoserine
-
pH 7.3, 30°C, gamma-replacement reaction
4.4
O-succinyl-L-homoserine
-
wild-type, pH 7.8, 25°C
5.4
O-succinyl-L-homoserine
-
mutant D45F, gamma-replacement, 25°C, pH 7.8
8
O-succinyl-L-homoserine
-
mutant N227A, pH 7.8, 25°C
8
O-succinyl-L-homoserine
-
mutant R49K, pH 7.8, 25°C
9
O-succinyl-L-homoserine
-
pH 7.3, 30°C, reaction wirh CH3SH
11
O-succinyl-L-homoserine
-
mutant R106A, pH 7.8, 25°C
13.34
O-succinyl-L-homoserine
-
pH 7.5, 30°C
19
O-succinyl-L-homoserine
-
mutant D45A, pH 7.8, 25°C
21
O-succinyl-L-homoserine
-
mutant S326A, pH 7.8, 25°C
39
O-succinyl-L-homoserine
-
mutant D45N, pH 7.8, 25°C
39
O-succinyl-L-homoserine
-
mutant R106K, pH 7.8, 25°C
45.5
O-succinyl-L-homoserine
-
-
45.5
O-succinyl-L-homoserine
-
-
90
O-succinyl-L-homoserine
-
mutant Y46F, pH 7.8, 25°C
0.7
O-Succinyl-L-serine
-
final, inhibited reaction phase
1.2
O-Succinyl-L-serine
-
initial reaction phase
additional information
additional information
-
kinetic analysis of the reaction O-succinyl-L-homoserine + beta-mercaptopropionate
-
additional information
additional information
-
detailed kinetics of elimination and replacement reaction, overview
-
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Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7
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Sagong, H.Y.; Kim, K.J.
Structural insights into substrate specificity of cystathionine gamma-synthase from Corynebacterium glutamicum
J. Agric. Food Chem.
65
6002-6008
2017
Corynebacterium glutamicum (H7C6A2)
brenda