2.5.1.16: spermidine synthase
This is an abbreviated version!
For detailed information about spermidine synthase, go to the full flat file.
Word Map on EC 2.5.1.16
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2.5.1.16
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polyamine
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spermine
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s-adenosylmethionine
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ornithine
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diamine
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samdc
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dicyclohexylamine
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alpha-difluoromethylornithine
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5'-methylthioadenosine
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cadaverine
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trypanothione
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adometdc
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agmatine
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4.1.1.50
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difluoromethylornithine
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medicine
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drug development
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methylthioadenosine
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thermospermine
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nutrition
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1,3-diaminopropane
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biotechnology
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norspermidine
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multisubstrate
- 2.5.1.16
- polyamine
- spermine
- s-adenosylmethionine
- ornithine
- diamine
- samdc
- dicyclohexylamine
- alpha-difluoromethylornithine
- 5'-methylthioadenosine
- cadaverine
- trypanothione
- adometdc
- agmatine
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4.1.1.50
- difluoromethylornithine
- medicine
- drug development
- methylthioadenosine
- thermospermine
- nutrition
- 1,3-diaminopropane
- biotechnology
- norspermidine
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multisubstrate
Reaction
Synonyms
aminopropyltransferase, aminopropyltransferase spermidine synthase, AtSPDS1, AtSPDS2, MdSPDS1, PAPT, PgSPD, putrescine aminopropyltransferase, Spd synthase, SPDS, SPDS2, SPDSYN, spe-sdh, spe3, SpeE, spermidine synthase, spermidine synthase 1, spermidine synthetase, Spm synthase, SpSyn, Synpcc7942_0628, synthase, spermidine
ECTree
2.5.1.16 spermidine synthaseAdvanced search results
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results (Engineering
Engineering on EC 2.5.1.16 - spermidine synthase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C159A
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
I163A
site-directed mutagenesis, replacement of Ile163 has no influence on EcSDPS activity
P162A
site-directed mutagenesis, replacement of Pro162 has no influence on EcSDPS activity
P165Q
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
T160A
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
D196N
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site-directed mutagenesis, the mutant activity is reduced by 89% compared to the wild-type enzyme
S197A
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site-directed mutagenesis, the mutant activity is reduced by 24% compared to the wild-type enzyme
Y102A
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site-directed mutagenesis, the mutant activity is reduced by 91% compared to the wild-type enzyme
D170A
site-directed mutagenesis, the mutsnt shows reduced activity compared to the wild-type enzyme
D173A
site-directed mutagenesis, the mutsnt shows reduced activity compared to the wild-type enzyme
Y76F
site-directed mutagenesis, the mutsnt shows reduced activity compared to the wild-type enzyme
additional information
additional information
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construction of transgenic Ipomoea batatas plants expressing the FSPD1 gene, the plants show twice as high spermidine content as the wild type counterpart in both leaves and storage roots, one of the most characteristic features of the transgenic plants is the increase in the number of storage roots formed under both non-stress and stressful environments, salt and drought stresses suppress storage root growth, but the transgenic plants are less affected producing significantly larger mass of storage roots and starches than wild-type plants under either stress, and also show increased tolerance to chilling- and heat-mediated damage to photosynthesis, phenotype, detailed overview
additional information
idefix(t26743), a mutation with a premature stop codon in the zebrafish gene encoding the enzyme spermidine synthase, leads to a severe reduction in spermidine levels
additional information
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idefix(t26743), a mutation with a premature stop codon in the zebrafish gene encoding the enzyme spermidine synthase, leads to a severe reduction in spermidine levels
additional information
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generation of transgenic mice overexpressing the human SpdS, the mice are viable and fertile and tissue SpdS activity is increased up to 9fold. This increased SpdS activity does not result in a dramatic elevation of spermidine or spermine levels but leads to a 1.5 to 2fold reduction in tissue spermine:spermidine ratio in heart, muscle and liver tissues with the highest levels of SpdS activity
additional information
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a strain overexpressing the enzyme shows a high level of resistance to n-butylamine, overview
additional information
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generation of a cell line deficient in spermidine synthase, created by double-targeted gene replacement within a virulent Leishmania donovani background
additional information
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generation of a cell line deficient in spermidine synthase, created by double-targeted gene replacement within a virulent Leishmania donovani background
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additional information
enzyme is able to functionally complement spermidine deficiency in yeast
additional information
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enzyme is able to functionally complement spermidine deficiency in yeast
additional information
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overexpression of apple spermidine synthase gene in pear. Spermidine titers in wild-type and transgenic lines show diverse changes upon stresses, and these changes are not consistent with the changes in spermidine synthase gene expressions. There are no differences in the sodium concentration in the shoots between the wild type and transgenic line, whereas the copper concentration is higher in the wild type than transgenic line
additional information
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transgenic pears overexpressing the apple enzyme show higher spermidine contents and enzyme activity than wild-type. No significant differences are detected between transgenic line and the wild type as regards contents of malondialdehyde and H2O2, and activities of antioxidant enzymes like superoxide dismutase, ascorbate peroxidase, monodehydroascorbate reductase and glutathione reductase. When exposed to NaCl or mannitol stress, both the wild-type and transgenic line exhibit accumulation of spermidine with the latter accumulating more. The transgenic line contains higher antioxidant enzyme activities, less malondialdehyde and H2O2 than the wild-type
additional information
downregulation by RNAi correlates with a decrease in intracellular spermidine and cessation of growth in bloodstream form parasites. Phenotype can be rescued by expression of Leishmania major spermidine synthase gene, but not by addition of spermidine to the growth medium
additional information
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downregulation by RNAi correlates with a decrease in intracellular spermidine and cessation of growth in bloodstream form parasites. Phenotype can be rescued by expression of Leishmania major spermidine synthase gene, but not by addition of spermidine to the growth medium
