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Literature summary for 2.5.1.16 extracted from
- Spermidine synthase is required for virulence of Leishmania donovani (2011), Infect. Immun., 79, 2764-2769.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | pharmacologic inhibition of spermidine ssynthase, and perhaps all components of the polyamine biosynthetic pathway, is a valid therapeutic strategy for the treatment of visceral and, potentially, other forms of leishmaniasis | Leishmania donovani |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of a cell line deficient in spermidine synthase, created by double-targeted gene replacement within a virulent Leishmania donovani background | Leishmania donovani |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
| Leishmania donovani LdBob | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SPDSYN | - |
Leishmania donovani |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | an enzyme-deficient strain is auxotrophic for polyamines, requires spermidine for growth in its insect vector form, and is adversely impacted in its ability to infect mice | Leishmania donovani |
| physiological function | spermidine synthase is required for virulence of Leishmania donovani | Leishmania donovani |
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Release 2023.1 (January 2023)
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