2.4.2.17: ATP phosphoribosyltransferase

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For detailed information about ATP phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

1-(5-phospho-D-ribosyl)-ATP:pyrophosphate phospho-alpha-D-ribosyltransferase, adenosine 5'-triphosphate phosphoribosyltransferase, adenosine triphosphate phosphoribosyltransferase, adenosine-triphosphate phosphoribosyltransferase, ATP phosphoribosyl transferase, ATP phosphoribosyl transferase complex, ATP phosphoribosyltransferase, ATP-phosphoribosyl transferase, ATP-phosphoribosyltransferase, ATP-PRT, ATP-PRT1, ATP-PRT2, ATP-PRTase, ATPPRT, HisG, HisGL, N-1-(5'-phosphoribosyl)-ATP transferase, phosphoribosyl ATP synthetase, phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase, phosphoribosyl-ATP pyrophosphorylase, phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase, phosphoribosyladenosine triphosphate pyrophosphorylase, phosphoribosyladenosine triphosphate synthetase, phosphoribosyltransferase, adenosine triphosphate

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.17 ATP phosphoribosyltransferase

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Results	in table
3	Activating Compound
36759	AA Sequence
3	Application
1	CAS Registry Number
20	Cloned(Commentary)
12	Crystallization (Commentary)
2	Expression
1	General Information
5	General Stability
14	IC50 Value
101	Inhibitors
18	kcat/KM [mM/s]
28	Ki Value [mM]
51	KM Value [mM]
1	Localization
19	Metals/Ions
18	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
253	Organism
6	Pathway
100	PDB ID
11	pH Optimum
1	pH Range
1	pH Stability
32	Protein Variants
25	Purification (Commentary)
8	Reaction
1	Reaction Type
49	Reference
13	Source Tissue
9	Specific Activity [micromol/min/mg]
5	Storage Stability
83	Substrates and Products (Substrate)
31	Subunits
77	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
29	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 2.4.2.17 - ATP phosphoribosyltransferase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

38.9

Psychrobacter arcticus

Q4FQF7

melting temperature for subunit HisZ

758806

42.9

Psychrobacter arcticus

Q4FQF7

melting temperature for subunit HisGS

758806

45

Salmonella enterica subsp. enterica serovar Typhimurium

-

very sensitive to heat inactivation, 0.4 mM histidine stabilizes the enzyme to inactivation by heat

637661

47.5

Escherichia coli

-

1.9 mg enzyme/ml, 80 min, 75% loss of activity without addition of AMP, with 0.05 mM AMP about 60% loss of activity, with 0.5 mM AMP about 40% loss of activity, with 5 mM AMP about 25% loss of activity

637668

48

Escherichia coli

-

3 mg enzyme/ml, 10 min, 15% remaining activity without addition of histidine, with 0.000086 mM histidine about 15% remaining activity after 15 min, with 0.00069 mM histidine about 70% remaining activity after 80 min, with 0.00345 mM histidine about 80% remaining activity after 80 min, with 0.0069 mM histidine about 55% remaining activity after 50 min

637668

52.5

Campylobacter jejuni

Q5HSJ4

melting temperature of the truncated long-form enzyme devoid of its regulatory domain

758757

60.7

Campylobacter jejuni

Q5HSJ4

melting temperature of the wild type long-form enzyme

758757

additional information

Escherichia coli

-

heat inactivation depends on protein concentration and inhibitors

637668