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2.4.2.17: ATP phosphoribosyltransferase

This is an abbreviated version!
For detailed information about ATP phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.17

Reaction

1-(5-phospho-beta-D-ribosyl)-ATP
+
diphosphate
=
ATP
+
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

1-(5-phospho-D-ribosyl)-ATP:pyrophosphate phospho-alpha-D-ribosyltransferase, adenosine 5'-triphosphate phosphoribosyltransferase, adenosine triphosphate phosphoribosyltransferase, adenosine-triphosphate phosphoribosyltransferase, ATP phosphoribosyl transferase, ATP phosphoribosyl transferase complex, ATP phosphoribosyltransferase, ATP-phosphoribosyl transferase, ATP-phosphoribosyltransferase, ATP-PRT, ATP-PRT1, ATP-PRT2, ATP-PRTase, ATPPRT, HisG, HisGL, N-1-(5'-phosphoribosyl)-ATP transferase, phosphoribosyl ATP synthetase, phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase, phosphoribosyl-ATP pyrophosphorylase, phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase, phosphoribosyladenosine triphosphate pyrophosphorylase, phosphoribosyladenosine triphosphate synthetase, phosphoribosyltransferase, adenosine triphosphate

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.17 ATP phosphoribosyltransferase

Reference

Reference on EC 2.4.2.17 - ATP phosphoribosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Martin, R.G.
The first enzyme in histidine biosynthesis: the nature of feedback inhibition by histidine
J. Biol. Chem.
238
257-268
1963
Salmonella enterica subsp. enterica serovar Typhimurium
-
Manually annotated by BRENDA team
Tebar, A.R.; Ballesteros, A.O.
Kinetic properties of ATP phosphoribosyltransferase of Escherichia coli
Mol. Cell. Biochem.
11
131-136
1976
Escherichia coli
Manually annotated by BRENDA team
Ames, B.N.; Martin, R.G.; Garry, B.J.
The first step in histidine biosynthesis
J. Biol. Chem.
236
2019-2026
1961
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Voll, M.J.; Appella, E.; Martin, R.G.
Purification and composition studies of phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase, the first enzyme of histidine biosynthesis
J. Biol. Chem.
242
1760-1767
1967
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Morton, D.P.; Parsons, S.M.
Synergistic inhibition of ATP phosphoribosyltransferase by guanosine tetraphosphate and histidine
Biochem. Biophys. Res. Commun.
74
172-177
1977
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Morton, D.P.; Parsons, S.M.
Inhibition of ATP phosphoribosyltransferase by AMP and ADP in the absence and presence of histidine
Arch. Biochem. Biophys.
181
643-648
1977
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Dall-Larsen, T.; Kryvi, H.; Klungsoyr, L.
Dinitrophenol, dicoumarol and pentachlorophenol as inhibitors and parasite substrates in the ATP phosphoribosyltransferase reaction
Eur. J. Biochem.
66
443-446
1976
Escherichia coli
Manually annotated by BRENDA team
Kryvi, H.
Thermal stability of phosphoribosyladenosine triphosphate synthetase as reflected in its circular dichroism and activity properties. Effect of inhibitors
Biochim. Biophys. Acta
317
123-130
1973
Escherichia coli
Manually annotated by BRENDA team
Parsons, S.M.; Koshland, D.E.
A rapid isolation of phosphoribosyladenosine triphosphate synthetase and comparison to native enzyme
J. Biol. Chem.
249
4104-4109
1974
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Morton, D.P.; Parsons, S.M.
Biosynthetic direction substrate kinetics and product inhibition studies on the first enzyme of histidine biosynthesis, adenosine triphosphate phosphoribosyltransferase
Arch. Biochem. Biophys.
175
677-686
1976
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Kleeman, J.E.; Parsons, S.M.
Reverse direction substrate kinetics and inhibition studies on the first enzyme of histidine biosynthesis, adenosine triphosphate phosphoribosyltransferase
Arch. Biochem. Biophys.
175
687-693
1976
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Mizukami, T.; Hamu, A.; Ideka, M.; Oka, T.; Katsumata, R.
Cloning of the ATP phosphoribosyl transferase gene of Corynebacterium glutamicum and application of the gene to L-histidine production
Biosci. Biotechnol. Biochem.
58
635-638
1994
Corynebacterium glutamicum
Manually annotated by BRENDA team
Ohta, D.; Fujimori, K.; Mizutani, M.; Nakayama, Y.; Kunpaisal-Hashimoto, R.; Munzer, S.; Kozaki, A.
Molecular cloning and characterization of ATP-phosphoribosyl transferase from Arabidopsis, a key enzyme in the histidine biosynthetic pathway
Plant Physiol.
122
907-914
2000
Arabidopsis thaliana, Arabidopsis thaliana (Q9S762)
Manually annotated by BRENDA team
Lohkamp, B.; Coggins, J.R.; Lapthorn, A.J.
Purification, crystallization and preliminary x-ray crystallographic analysis of ATP-phosphoribosyltransferase from Escherichia coli
Acta Crystallogr. Sect. D
56
1488-1491
2000
Escherichia coli
Manually annotated by BRENDA team
Cho, Y.; Sharma, V.; Sacchettini, J.C.
Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis
J. Biol. Chem.
278
8333-8339
2003
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Champagne, K.S.; Sissler, M.; Larrabee, Y.; Doublie, S.; Francklyn, C.S.
Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog
J. Biol. Chem.
280
34096-34104
2005
Lactococcus lactis
Manually annotated by BRENDA team
Lohkamp, B.; McDermott, G.; Campbell, S.A.; Coggins, J.R.; Lapthorn, A.J.
The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition
J. Mol. Biol.
336
131-144
2004
Escherichia coli (P60757), Escherichia coli
Manually annotated by BRENDA team
Vega, M.C.; Zou, P.; Fernandez, F.J.; Murphy, G.E.; Sterner, R.; Popov, A.; Wilmanns, M.
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit
Mol. Microbiol.
55
675-686
2005
Thermotoga maritima
Manually annotated by BRENDA team
Champagne, K.S.; Piscitelli, E.; Francklyn, C.S.
Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from Lactococcus lactis
Biochemistry
45
14933-14943
2006
Lactococcus lactis
Manually annotated by BRENDA team
Ingle, R.A.; Mugford, S.T.; Rees, J.D.; Campbell, M.M.; Smith, J.A.
Constitutively high expression of the histidine biosynthetic pathway contributes to nickel tolerance in hyperaccumulator plants
Plant Cell
17
2089-2106
2005
Odontarrhena serpyllifolia, Alyssum montanum (Q56US5), Alyssum montanum, Odontarrhena lesbiaca (Q56UT2), Odontarrhena lesbiaca (Q56UT3), Odontarrhena lesbiaca
Manually annotated by BRENDA team
Cho, Y.; Ioerger, T.R.; Sacchettini, J.C.
Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening
J. Med. Chem.
51
5984-5992
2008
Mycolicibacterium smegmatis, Mycobacterium tuberculosis (P9WMN1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WMN1)
Manually annotated by BRENDA team
Pedreno, S.; Pisco, J.P.; Larrouy-Maumus, G.; Kelly, G.; de Carvalho, L.P.
Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase
Biochemistry
51
8027-8038
2012
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Zhang, Y.; Shang, X.; Deng, A.; Chai, X.; Lai, S.; Zhang, G.; Wen, T.
Genetic and biochemical characterization of Corynebacterium glutamicum ATP phosphoribosyltransferase and its three mutants resistant to feedback inhibition by histidine
Biochimie
94
829-838
2012
Corynebacterium glutamicum (Q9Z472), Corynebacterium glutamicum
Manually annotated by BRENDA team
Kulis-Horn, R.K.; Persicke, M.; Kalinowski, J.
Corynebacterium glutamicum ATP-phosphoribosyl transferases suitable for L-histidine production - Strategies for the elimination of feedback inhibition
J. Biotechnol.
206
26-37
2015
Corynebacterium glutamicum (Q9Z472), Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032 (Q9Z472)
Manually annotated by BRENDA team
Mittelstaedt, G.; Moggre, G.J.; Panjikar, S.; Nazmi, A.R.; Parker, E.J.
Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer which is allosterically controlled by the twisting of a regulatory tail
Protein Sci.
25
1492-1506
2016
Campylobacter jejuni (Q9PM78), Campylobacter jejuni, Campylobacter jejuni NCTC 11168 (Q9PM78)
Manually annotated by BRENDA team
Alphey, M.; Fisher, G.; Ge, Y.; Gould, E.; Machado, T.; Liu, H.; Florence, G.; Naismith, J.; Da Silva, R.
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase
ACS Catal.
8
5601-5610
2018
Psychrobacter arcticus (Q4FQF7), Psychrobacter arcticus DSM 17307 (Q4FQF7)
-
Manually annotated by BRENDA team
Moggre, G.J.; Poulin, M.B.; Tyler, P.C.; Schramm, V.L.; Parker, E.J.
Transition state analysis of adenosine triphosphate phosphoribosyltransferase
ACS Chem. Biol.
12
2662-2670
2017
Mycobacterium tuberculosis (P9WMN1), Mycobacterium tuberculosis, Lactococcus lactis (Q02129), Lactococcus lactis, Campylobacter jejuni (Q5HSJ4), Campylobacter jejuni, Mycobacterium tuberculosis H37Rv (P9WMN1), Campylobacter jejuni RM1221 (Q5HSJ4)
Manually annotated by BRENDA team
Wan, P.J.; Tang, Y.H.; Yuan, S.Y.; Wang, W.X.; Lai, F.X.; Yu, X.P.; Fu, Q.
ATP phosphoribosyltransferase from symbiont Entomomyces delphacidicola invovled in histidine biosynthesis of Nilaparvata lugens (Stal)
Amino Acids
48
2605-2617
2016
Nilaparvata lugens
Manually annotated by BRENDA team
Mittelstaedt, G.; Jiao, W.; Livingstone, E.K.; Moggre, G.J.; Nazmi, A.R.; Parker, E.J.
A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase
Biochem. J.
475
247-260
2018
Campylobacter jejuni (Q5HSJ4), Campylobacter jejuni RM 1221 (Q5HSJ4)
Manually annotated by BRENDA team
Ruszkowski, M.
Guarding the gateway to histidine biosynthesis in plants Medicago truncatula ATP-phosphoribosyltransferase in relaxed and tense states
Biochem. J.
475
2681-2697
2018
Medicago truncatula (G7JFL4), Medicago truncatula
Manually annotated by BRENDA team
Stroek, R.; Ge, Y.; Talbot, P.D.; Glok, M.K.; Bernas, K.E.; Thomson, C.M.; Gould, E.R.; Alphey, M.S.; Liu, H.; Florence, G.J.; Naismith, J.H.; da Silva, R.G.
Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase
Biochemistry
56
793-803
2017
Psychrobacter arcticus (Q4FQF7), Psychrobacter arcticus DSM 17307 (Q4FQF7)
Manually annotated by BRENDA team
Fisher, G.; Thomson, C.M.; Stroek, R.; Czekster, C.M.; Hirschi, J.S.; da Silva, R.G.
Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase
Biochemistry
57
4357-4367
2018
Psychrobacter arcticus (Q4FQF7), Psychrobacter arcticus DSM 17307 (Q4FQF7)
Manually annotated by BRENDA team
Jiao, W.; Mittelstaedt, G.; Moggre, G.J.; Parker, E.J.
Hinge twists and population shifts deliver regulated catalysis for ATP-PRT in histidine biosynthesis
Biophys. J.
116
1887-1897
2019
Campylobacter jejuni (Q5HSJ4), Campylobacter jejuni RM1221 (Q5HSJ4)
Manually annotated by BRENDA team