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2.4.1.226: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

This is an abbreviated version!
For detailed information about N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.226

Reaction

UDP-alpha-D-glucuronate
+
[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
UDP
 +
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

AcbD, ApCS, bifunctional CS synthase, ChGn-1, ChGn-2, chondroitin beta-glucuronyltransferase, chondroitin glucuronyltransaferase II, chondroitin glucuronyltransferase, chondroitin glucuronyltransferase II, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucoronyltransferase, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glucuronyltransferase/chondroitin synthase-3, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase-3, CHPF, ChSy, ChSy-1, ChSy-3, CHSY1, CHSY2, CHSY3, CS N-acetylgalactosaminyltransferase-1, CS synthase 1, CSGalNAcT-1, CSGlcA-T, CSGlcAT, CSGlcAT-II, CSGlcAT/ChSy-3, CSS1, CSS2, GlcAT-II, glucuronyltransferase, uridine diphosphoglucuronate-chondroitin, glucuronyltransferase-II, More, UDP-glucuronate:chondroitin glucuronyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

Cloned

Cloned on EC 2.4.1.226 - N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
CSGlcAT/ChSy-3 quantitative tissue expression analysis by realtime RT-PCR, overview
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DNA and amino acid sequence determination and analysis, expression of putative catalytic domains of CSGlcAT-II and CSS2 in COS-7 cells as FLAG-tagged soluble proteins, which possesses glucuronyltransferase and N-acetylgalactosaminyltransferase activities as the wild-type enzyme
enzyme domain containing beta-3-glycosyltransferase motifs, expressed in COS-7 cells ATCCCRL 1651
expressed in COS-1 cells
gene acbD, encoded within the presumed capsule biosynthesis gene cluster, functional recombinant expression of N-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3) as soluble protein
gene ChSy-1, genotyping in healthy persons and multiple sclerosis patients, recombinant expression of wild-type and mutant enzymes in COS-1 cells
gene CHSY1, quantitative RT-PCR enzyme expressiona analysis
gene chsy1, real-time PCR enzyme expression analysis
-
gene CHSY1, soluble forms of wild-type and mutant ChSy-1 is heterologously expressed in COS-1 cells, the recombinant enzymes are secreted to the medium, quantitative real-time RT-PCR enzyme expression analysis
genetic organization, coexpression of enzyme and chondroitin polymerizing factor as fusion protein in COS-1 cells, secretion into the cell culture medium
individual overexpression of soluble forms of FLAG- and Myc-tagged splice variants CSS2A and CSS2B in COS-7 cells, co-expression with CSS1. Whereas CSS2A facilitates chondroitin sulfate biosynthesis, CSS2B inhibits it. Analysis of transcription levels of CSS2 variants
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RT-PCR expression analysis of CHSY1, CHSY3 and CSGlcA-T from macroscopically normal and pathological specimens, overview
-