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2.4.1.226: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

This is an abbreviated version!
For detailed information about N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.226

Reaction

UDP-alpha-D-glucuronate
+
[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
UDP
 +
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

AcbD, ApCS, bifunctional CS synthase, ChGn-1, ChGn-2, chondroitin beta-glucuronyltransferase, chondroitin glucuronyltransaferase II, chondroitin glucuronyltransferase, chondroitin glucuronyltransferase II, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucoronyltransferase, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glucuronyltransferase/chondroitin synthase-3, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase-3, CHPF, ChSy, ChSy-1, ChSy-3, CHSY1, CHSY2, CHSY3, CS N-acetylgalactosaminyltransferase-1, CS synthase 1, CSGalNAcT-1, CSGlcA-T, CSGlcAT, CSGlcAT-II, CSGlcAT/ChSy-3, CSS1, CSS2, GlcAT-II, glucuronyltransferase, uridine diphosphoglucuronate-chondroitin, glucuronyltransferase-II, More, UDP-glucuronate:chondroitin glucuronyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

Reference

topprint

Reference on EC 2.4.1.226 - N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kitagawa, H.; Ujikawa, M.; Sugahara, K.
Developmental changes in serum UDP-GlcA:chondroitin glucuronyltransferase activity
J. Biol. Chem.
271
6583-6585
1996
Bos taurus, Gallus gallus gallus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kitagawa, H.; Ujikawa, M.; Tsutsumi, K.; Tamura, J.I.; Neumann, K.W.; Ogawa, T.; Sugahara, K.
Characterization of serum beta-glucuronyltransferase involved in chondroitin sulfate biosynthesis
Glycobiology
7
905-911
1997
Bos taurus
Manually annotated by BRENDA team
Gotoh, M.; Yada, T.; Sato, T.; Akashima, T.; Iwasaki, H.; Mochizuki, H.; Inaba, N.; Togayachi, A.; Kudo, T.; Watanabe, H.; Kimata, K.; Narimatsu, H.
Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine
J. Biol. Chem.
277
38179-38188
2002
Homo sapiens (Q9P2E5), Homo sapiens
Manually annotated by BRENDA team
Kitagawa, H.; Izumikawa, T.; Uyama, T.; Sugahara, K.
Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization
J. Biol. Chem.
278
23666-23671
2003
Homo sapiens (Q8IZ52), Homo sapiens
Manually annotated by BRENDA team
Yada, T.; Gotoh, M.; Sato, T.; Shionyu, M.; Go, M.; Kaseyama, H.; Iwasaki, H.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Watanabe, H.; Narimatsu, H.; Kimata, K.
Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities
J. Biol. Chem.
278
30235-30247
2003
Homo sapiens (Q8IZ52), Homo sapiens
Manually annotated by BRENDA team
Sakai, K.; Kimata, K.; Sato, T.; Gotoh, M.; Narimatsu, H.; Shinomiya, K.; Watanabe, H.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage
J. Biol. Chem.
282
4152-4161
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Izumikawa, T.; Uyama, T.; Okuura, Y.; Sugahara, K.; Kitagawa, H.
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor
Biochem. J.
403
545-552
2007
Homo sapiens, Homo sapiens (A2V663)
Manually annotated by BRENDA team
Ogawa, H.; Shionyu, M.; Sugiura, N.; Hatano, S.; Nagai, N.; Kubota, Y.; Nishiwaki, K.; Sato, T.; Gotoh, M.; Narimatsu, H.; Shimizu, K.; Kimata, K.; Watanabe, H.
Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function
J. Biol. Chem.
285
34155-34167
2010
Mus musculus, Mus musculus C57/BL6
Manually annotated by BRENDA team
Kalathas, D.; Theocharis, D.A.; Bounias, D.; Kyriakopoulou, D.; Papageorgakopoulou, N.; Stavropoulos, M.S.; Vynios, D.H.
Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer
Mol. Med. Rep.
4
363-368
2011
Mus musculus
Manually annotated by BRENDA team
Ogawa, H.; Hatano, S.; Sugiura, N.; Nagai, N.; Sato, T.; Shimizu, K.; Kimata, K.; Narimatsu, H.; Watanabe, H.
Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development
PLoS ONE
7
e43806
2012
Mus musculus
Manually annotated by BRENDA team
Izumikawa, T.; Saigoh, K.; Shimizu, J.; Tsuji, S.; Kusunoki, S.; Kitagawa, H.
A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1
Biochim. Biophys. Acta
1830
4806-4812
2013
Homo sapiens (Q86X52)
Manually annotated by BRENDA team
Hu, B.; Shi, C.; Tian, Y.; Zhang, Y.; Xu, C.; Chen, H.; Cao, P.; Yuan, W.
TGF-beta induces up-regulation of chondroitin sulfate synthase 1 (CHSY1) in nucleus pulposus cells through MAPK signaling
Cell. Physiol. Biochem.
37
793-804
2015
Rattus norvegicus
Manually annotated by BRENDA team
Saigoh, K.; Yoshimura, S.; Izumikawa, T.; Miyata, S.; Tabara, Y.; Matsushita, T.; Miki, T.; Miyamoto, K.; Hirano, M.; Kitagawa, H.; Kira, J.I.; Kusunoki, S.
Chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: association with progression of multiple sclerosis
Neurosci. Res.
108
55-59
2016
Homo sapiens (Q86X52), Homo sapiens
Manually annotated by BRENDA team
Wang, T.T.; Zhu, C.Y.; Zheng, S.; Meng, C.C.; Wang, T.T.; Meng, D.H.; Li, Y.J.; Zhu, H.M.; Wang, F.S.; Sheng, J.Z.
Identification and characterization of a chondroitin synthase from Avibacterium paragallinarum
Appl. Microbiol. Biotechnol.
102
4785-4797
2018
Avibacterium paragallinarum (D0QYM5), Avibacterium paragallinarum, Avibacterium paragallinarum ATCC 29545 (D0QYM5), Avibacterium paragallinarum NCTC 11296 (D0QYM5)
Manually annotated by BRENDA team
Adhikara, I.M.; Yagi, K.; Mayasari, D.S.; Ikeda, K.; Kitagawa, H.; Miyata, O.; Igarashi, M.; Hatakeyama, K.; Asada, Y.; Hirata, K.I.; Emoto, N.
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration
Biochem. Biophys. Res. Commun.
509
89-95
2019
Mus musculus (Q6IQX7), Mus musculus, Homo sapiens (Q8IZ52), Homo sapiens, Mus musculus C57BL/6J (Q6IQX7)
Manually annotated by BRENDA team
Momose, T.; Yoshimura, Y.; Harumiya, S.; Isobe, K.; Kito, M.; Fukushima, M.; Kato, H.; Nakayama, J.
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance
Hum. Pathol.
50
15-23
2016
Homo sapiens (Q86X52)
Manually annotated by BRENDA team
Liao, W.C.; Liao, C.K.; Tseng, T.J.; Ho, Y.J.; Chen, Y.R.; Lin, K.H.; Lai, T.J.; Lan, C.T.; Wei, K.C.; Liu, C.H.
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability
Oncogenesis
9
9
2020
Homo sapiens (Q86X52), Homo sapiens
Manually annotated by BRENDA team
Ida-Yonemochi, H.; Morita, W.; Sugiura, N.; Kawakami, R.; Morioka, Y.; Takeuchi, Y.; Sato, T.; Shibata, S.; Watanabe, H.; Imamura, T.; Igarashi, M.; Ohshima, H.; Takeuchi, K.
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1
Sci. Rep.
8
17134
2018
Mus musculus (Q6ZQ11)
Manually annotated by BRENDA team