2.4.1.226: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

This is an abbreviated version!
For detailed information about N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.226

2.4.1.226

glycosaminoglycans

proteoglycans

tetrasaccharide

dermatan

polymerizing

csgalnact1

hyperelongation

brachydactyly

glcua

unsulfated

preaxial

medicine

Reaction

[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

AcbD, ApCS, bifunctional CS synthase, ChGn-1, ChGn-2, chondroitin beta-glucuronyltransferase, chondroitin glucuronyltransaferase II, chondroitin glucuronyltransferase, chondroitin glucuronyltransferase II, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucoronyltransferase, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glucuronyltransferase/chondroitin synthase-3, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase-3, CHPF, ChSy, ChSy-1, ChSy-3, CHSY1, CHSY2, CHSY3, CS N-acetylgalactosaminyltransferase-1, CS synthase 1, CSGalNAcT-1, CSGlcA-T, CSGlcAT, CSGlcAT-II, CSGlcAT/ChSy-3, CSS1, CSS2, GlcAT-II, glucuronyltransferase, uridine diphosphoglucuronate-chondroitin, glucuronyltransferase-II, More, UDP-glucuronate:chondroitin glucuronyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

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Results	in table
2	Activating Compound
163	AA Sequence
4	Application
2	CAS Registry Number
12	Cloned(Commentary)
112	Disease/ Diagnostics
3	Expression
28	General Information
4	Inhibitors
6	KM Value [mM]
13	Localization
15	Metals/Ions
20	Natural Substrates/ Products (Substrates)
36	Organism
5	Pathway
6	PDB ID
7	pH Optimum
13	Protein Variants
5	Purification (Commentary)
9	Reaction
2	Reaction Type
27	Reference
44	Source Tissue
11	Specific Activity [micromol/min/mg]
56	Substrates and Products (Substrate)
6	Subunits
78	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.226 - N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

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NDP-glucose + 3-phospho-D-glycerate

NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

3 entries

UDP-alpha-D-glucuronate + chondroitin

UDP + beta-D-glucuronosyl-(1,3)-chondroitin

Homo sapiens

Q8IZ52

chondroitin polymerization in disaccharide units by glucuronyltransferase and N-acetylgalactosaminyltransferase activities of the enzyme

659218

UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan

UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan

5 entries

UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan

UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan

5 entries

additional information

4 entries