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2.3.3.5: 2-methylcitrate synthase

This is an abbreviated version!
For detailed information about 2-methylcitrate synthase, go to the full flat file.

Word Map on EC 2.3.3.5

Reaction

propanoyl-CoA
+
H2O
 +
oxaloacetate
=
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
 +
CoA

Synonyms

2-MC synthase, 2-MCS, 2-MCS1, 2-methylcitrate oxaloacetate-lyase, 2-methylcitrate synthase 2, citrate synthase II, citrate synthase/2-methylcitrate synthase, EC 4.1.3.31, MCA condensing enzyme, MCS, Mcs1, mcsA, Methylcitrate synthase, methylcitrate synthetase, mmgD, MscA, PrpC, prpC2, Rv1131

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.5 2-methylcitrate synthase

Expression

Expression on EC 2.3.3.5 - 2-methylcitrate synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the de novo protein SynGltA stimulates the prp operon. SynGltA allows cells to recover from a defect in central carbon and energy metabolism by altering the regulation of an alternative metabolic pathway. Specifically, SynGltA dramatically enhances the expression of prpC, a gene encoding methylcitrate synthase in the propionate degradation pathway. This endogenous protein has promiscuous catalytic activity, which when overexpressed, compensates for the deletion of citrate synthase
the enzyme is up-regulated during appressorium formation and when grown on propionyl-CoA-producing carbon sources
-
the nitrogen regulator GlnR regulates the methylcitrate cycle through direct repression of the transcription of the prpDBC operon
-