2.3.3.5: 2-methylcitrate synthase

This is an abbreviated version!
For detailed information about 2-methylcitrate synthase, go to the full flat file.

Word Map on EC 2.3.3.5

2.3.3.5

propionate

propionyl-coa

dehydratase

acetyl-coa

3-hydroxyvalerate

mcsa

methylisocitrate

polyhydroxyalkanoates

methylmalonyl-coa

propionyl

eutropha

halomonas

paracoccidioidomycosis

odd-chain

drug development

lutzii

paracoccidioides

coa-transferase

prpbcde

butyryl-coa

medicine

agriculture

Reaction

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate

Synonyms

2-MC synthase, 2-MCS, 2-MCS1, 2-methylcitrate oxaloacetate-lyase, 2-methylcitrate synthase 2, citrate synthase II, citrate synthase/2-methylcitrate synthase, EC 4.1.3.31, MCA condensing enzyme, MCS, Mcs1, mcsA, Methylcitrate synthase, methylcitrate synthetase, mmgD, MscA, PrpC, prpC2, Rv1131

ECTree

2 Transferases

2.3 Acyltransferases

2.3.3 Acyl groups converted into alkyl groups on transfer

2.3.3.5 2-methylcitrate synthase

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Results	in table
1	Activating Compound
271	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
4	Cofactor
1	Crystallization (Commentary)
3	Expression
14	General Information
22	Inhibitors
8	kcat/KM [mM/s]
15	Ki Value [mM]
43	KM Value [mM]
10	Localization
4	Metals/Ions
17	Molecular Weight [Da]
137	Natural Substrates/ Products (Substrates)
501	Organism
6	Pathway
42	PDB ID
6	pH Optimum
4	pH Range
1	pH Stability
4	pI Value
1	Posttranslational Modification
5	Protein Variants
17	Purification (Commentary)
2	Reaction
5	Reaction Type
131	Reference
2	Source Tissue
65	Specific Activity [micromol/min/mg]
213	Substrates and Products (Substrate)
13	Subunits
45	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
5	Temperature Range [°C]
5	Temperature Stability [°C]
14	Turnover Number [1/s]

Engineering

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Engineering on EC 2.3.3.5 - 2-methylcitrate synthase

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AW81Y

Aspergillus fumigatus

Q50I20

no measurable activity

756131

G352A

Aspergillus fumigatus

Q50I20

mutation does not appear to have an impact on positioning of active site residues

756131

G419A

Aspergillus fumigatus

Q50I20

no measurable activity

756131

additional information

3 entries