2.3.3.5: 2-methylcitrate synthase
This is an abbreviated version!
For detailed information about 2-methylcitrate synthase, go to the full flat file.
Word Map on EC 2.3.3.5
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2.3.3.5
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propionate
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propionyl-coa
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dehydratase
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acetyl-coa
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3-hydroxyvalerate
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mcsa
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methylisocitrate
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polyhydroxyalkanoates
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methylmalonyl-coa
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propionyl
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eutropha
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halomonas
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paracoccidioidomycosis
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odd-chain
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drug development
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lutzii
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paracoccidioides
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coa-transferase
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prpbcde
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butyryl-coa
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medicine
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agriculture
- 2.3.3.5
- propionate
- propionyl-coa
- dehydratase
- acetyl-coa
- 3-hydroxyvalerate
- mcsa
- methylisocitrate
- polyhydroxyalkanoates
- methylmalonyl-coa
-
propionyl
- eutropha
- halomonas
-
paracoccidioidomycosis
-
odd-chain
- drug development
- lutzii
- paracoccidioides
-
coa-transferase
-
prpbcde
- butyryl-coa
- medicine
- agriculture
Reaction
Synonyms
2-MC synthase, 2-MCS, 2-MCS1, 2-methylcitrate oxaloacetate-lyase, 2-methylcitrate synthase 2, citrate synthase II, citrate synthase/2-methylcitrate synthase, EC 4.1.3.31, MCA condensing enzyme, MCS, Mcs1, mcsA, Methylcitrate synthase, methylcitrate synthetase, mmgD, MscA, PrpC, prpC2, Rv1131
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Reaction
Reaction on EC 2.3.3.5 - 2-methylcitrate synthase
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propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
the enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme has been separated from EC 2.3.3.1 citrate (Si) synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate
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