2.3.1.86: fatty-acyl-CoA synthase system
This is an abbreviated version!
For detailed information about fatty-acyl-CoA synthase system, go to the full flat file.
Word Map on EC 2.3.1.86
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2.3.1.86
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udp-glucuronosyltransferase
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glucuronidation
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farnesoid
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carvedilol
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extrahepatic
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acid-conjugating
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parapsilosis
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hyodeoxycholic
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4-hydroxyestrone
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analysis
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medicine
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biofuel production
- 2.3.1.86
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udp-glucuronosyltransferase
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glucuronidation
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farnesoid
- carvedilol
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extrahepatic
-
acid-conjugating
- parapsilosis
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hyodeoxycholic
- 4-hydroxyestrone
- analysis
- medicine
- biofuel production
Reaction
Synonyms
CpFas2, FAS, FAS1, fas2, fatty acid synthase, fatty-acyl-CoA synthase, yeast fatty acid synthase
ECTree
2.3.1.86 fatty-acyl-CoA synthase systemAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.3.1.86 - fatty-acyl-CoA synthase system
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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FAS-A mainly synthesizes the C18 fatty acids oleate and stearate with only traces of palmitate, the major product of FAS-B is pamitate
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acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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synthesis of saturated and unsaturated fatty acids, FAS-B cannot synthesize oleic acid
?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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primers instead of acetyl-CoA: propionyl-CoA, butyryl-CoA or hexanoyl-CoA
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-
?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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-
-
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?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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stable multifunctional enzyme complex: carries acetyl-CoA and malonyl-CoA transacylase, beta-ketoacyl reductase, beta-hydroxyacyl dehydrase activities on beta-subunits and condensing enzyme, i.e. beta-ketoacyl synthetase, enoylacyl reductase activities and acyl-carrier-protein components on alpha-subunits
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?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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S-acetylpantetheine and S-malonylpantetheine and saturated acetyl-CoA derivatives can replace acetyl-CoA and malonyl-CoA
palmitoyl-CoA and steraoyl-CoA are main products, myristoyl-CoA is produced in small amounts
?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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mutants require acyl-CoA primers of 10 or more carbon atoms, maximal activity with 12-14 carbon atoms
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?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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intermediates are never released into the medium
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-
?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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mutants require acyl-CoA primers of 10 or more carbon atoms, maximal activity with 12-14 carbon atoms
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-
?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
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-
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?
acetyl-CoA + malonyl-CoA + NADH + NADPH
?
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multifunctional enzyme involved in yeast fat metabolism
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?
acetyl-CoA + malonyl-CoA + NADH + NADPH
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multifunctional enzyme involved in yeast fat metabolism
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?
acetyl-CoA + malonyl-CoA + NADH + NADPH
?
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multifunctional enzyme involved in yeast fat metabolism
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?
acetyl-CoA + malonyl-CoA + NADH + NADPH
?
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multifunctional enzyme involved in yeast fat metabolism
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?
additional information
?
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fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes
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?
additional information
?
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narrow substrate specificity for both the acyl donor and the acyl carrier protein acceptor. Exclusive transfer of malonyl-CoA moieties to the mitochondrial holoacyl carrier protein
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?
additional information
?
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fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes
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?
