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2.3.1.86: fatty-acyl-CoA synthase system

This is an abbreviated version!
For detailed information about fatty-acyl-CoA synthase system, go to the full flat file.

Word Map on EC 2.3.1.86

Reaction

acetyl-CoA
+ 7 malonyl-CoA + 14 NADPH + 14 H+ =
hexadecanoyl-CoA
+ 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O

Synonyms

CpFas2, FAS, FAS1, fas2, fatty acid synthase, fatty-acyl-CoA synthase, yeast fatty acid synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.86 fatty-acyl-CoA synthase system

Reference

Reference on EC 2.3.1.86 - fatty-acyl-CoA synthase system

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vagelos, R.P.
Acyl group transfer (acyl carrier protein)
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
8
155-199
1973
Saccharomyces cerevisiae, Escherichia coli, Euglena gracilis, Mycolicibacterium phlei
-
Manually annotated by BRENDA team
Worsham, L.M.S.; Williams, S.G.; Ernst-Fonberg, M.L.
Early catalytic steps of Euglena gracilis chloroplast type II fatty acid synthase
Biochim. Biophys. Acta
1170
62-71
1993
Euglena gracilis
Manually annotated by BRENDA team
Wakil, S.J.; Stoops, J.K.; Joshi, V.C.
Fatty acid synthesis and its regulation
Annu. Rev. Biochem.
52
537-579
1983
Saccharomyces cerevisiae, Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Stuible, H.P.; Meurer, G.; Schweizer, E.
Heterologous expression and biochemical characterization of two functionally different type I fatty acid synthases from Brevibacterium ammoniagenes
Eur. J. Biochem.
247
268-273
1997
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Stuible, H.P.; Wagner, C.; Andreou, J.; Guter, G.; Haselmann, J.; Schweizer, E.
Identification and functional differentiation of two type I fatty acid synthases in Brevibacterium ammoniagenes
J. Bacteriol.
178
4787-4793
1996
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Schweizer, E.; Kniep, B.; Castorph, H.; Holzner, U.
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex
Eur. J. Biochem.
39
353-362
1973
Saccharomyces cerevisiae, Saccharomyces cerevisiae X-2180-A
Manually annotated by BRENDA team
Ziegenhorn, J.; Niedermeier, R.; Nussler, C.; Lynen, F.
Study of the acetyltransferase component of fatty acid synthetase of yeast
Eur. J. Biochem.
30
285-300
1972
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wieland, F.; Renner, L.; Verfurth, C.; Lynen, F.
Studies on the multi-enzyme complex of yeast fatty-acid synthetase. Reversible dissociation and isolation of two polypeptide chains
Eur. J. Biochem.
94
189-197
1979
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Stoops, J.K.; Wakil, S.J.
The isolation of the two subunits of yeast fatty acid synthetase
Biochem. Biophys. Res. Commun.
84
225-231
1978
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yein, F.; Brown, O.R.
Comparative inactivation of yeast fatty acid synthetase component enzymes by 100 atmospheres of oxygen
Biochim. Biophys. Acta
486
421-428
1977
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lynen, F.
Yeast fatty acid synthase
Methods Enzymol.
14
17-33
1969
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Stoops, J.K.; Wakil, S.J.
Studies on the yeast fatty acid synthetase. Subunit composition and structural organization of a large multifunctional enzyme complex
J. Biol. Chem.
253
4464-4475
1978
Saccharomyces cerevisiae, Saccharomyces cerevisiae Fleishmann
Manually annotated by BRENDA team
Stoops, J.K.; Wakil, S.J.
Yeast fatty acid synthetase: structure-function relationship and nature of the beta-ketoacyl synthetase site
Proc. Natl. Acad. Sci. USA
77
4544-4548
1980
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Engeser, H.; Hubner, K.; Straub, J.; Lynen, F.
Identity of malonyl and palmitoyl transferase of fatty acid synthetase from yeast. Functional interrelationships between the acyl transferases
Eur. J. Biochem.
101
407-412
1979
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Engeser, H.; Hubner, K.; Straub, J.; Lynen, F.
Identity of malonyl and palmitoyl transferase of fatty acid synthetase from yeast. 2. A comparison of active-site peptides
Eur. J. Biochem.
101
413-422
1979
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Vance, D.E.; Mitsuhashi, O.; Bloch, K.
Purification and properties of the fatty acid synthetase from Mycobacterium phlei
J. Biol. Chem.
248
2303-2309
1973
Mycolicibacterium phlei
Manually annotated by BRENDA team
Allen, E.E.; Bartlett, D.H.
Structure and regulation of the omega-3 polyunsaturated fatty acid synthase genes from the deep-sea bacterium Photobacterium profundum strain SS9
Microbiology
148
1903-1913
2002
Photobacterium profundum, Photobacterium profundum SS9
Manually annotated by BRENDA team
Dittrich, F.; Zajonc, D.; Huhne, K.; Hoja, U.; Ekici, A.; Greiner, E.; Klein, H.; Hofmann, J.; Bessoule, J.J.; Sperling, P.; Schweizer, E.
Fatty acid elongation in yeast. Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants
Eur. J. Biochem.
252
477-485
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Jones, L.A.; Herbert, D.; Rutter, A.J.; Dancer, J.E.; Harwood, J.L.
Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (pisum sativum)
Biochem. J.
347
205-209
2000
Pisum sativum
-
Manually annotated by BRENDA team
Roughan, P.G.
Stromal concentrations of coenzyme A and its esters are insufficient to account for rates of chloroplast fatty acid synthesis: evidence for substrate channeling within the chloroplast fatty acid synthase
Biochem. J.
327
267-273
1997
Pisum sativum, Spinacia oleracea
-
Manually annotated by BRENDA team
Schuster, H.; Rautenstrauss, B.; Mittag, M.; Stratmann, D.; Schweizer, E.
Substrate and product binding sites of yeast fatty acid synthase. Stoichiometry and binding kinetics of wild-type and in vitro mutated enzymes
Eur. J. Biochem.
228
417-424
1995
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gong, H.; Byers, D.M.
Glutamate-41 of Vibrio harveyi acyl carrier protein is essential for fatty acid synthase but not acyl-ACP synthetase activity
Biochem. Biophys. Res. Commun.
302
35-40
2003
Vibrio harveyi
Manually annotated by BRENDA team
Zhang, L.; Joshi, A.K.; Smith, S.
Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein
J. Biol. Chem.
278
40067-40074
2003
Homo sapiens
Manually annotated by BRENDA team
Oura, T.; Kajiwara, S.
Cloning and functional characterization of a fatty acid synthase component FAS2 gene from Saccharomyces kluyveri
Curr. Genet.
49
393-402
2006
Lachancea kluyveri (Q765N2)
Manually annotated by BRENDA team
Jenni, S.; Leibundgut, M.; Maier, T.; Ban, N.
Architecture of a fungal fatty acid synthase at 5 A resolution
Science
311
1263-1267
2006
Thermomyces lanuginosus
Manually annotated by BRENDA team
Jenni, S.; Leibundgut, M.; Boehringer, D.; Frick, C.; Mikolasek, B.; Ban, N.
Structure of fungal fatty acid synthase and implications for iterative substrate shuttling
Science
316
254-261
2007
Thermomyces lanuginosus
Manually annotated by BRENDA team
Leibundgut, M.; Jenni, S.; Frick, C.; Ban, N.
Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase
Science
316
288-290
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lomakin, I.B.; Xiong, Y.; Steitz, T.A.
The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together
Cell
129
319-332
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Nguyen, L.N.; Trofa, D.; Nosanchuk, J.D.
Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection
PLoS ONE
4
e8421
2009
Candida parapsilosis
Manually annotated by BRENDA team
Wallace, J.; Bowlin, N.O.; Mills, D.M.; Saenkham, P.; Kwasny, S.M.; Opperman, T.J.; Williams, J.D.; Rock, C.O.; Bowlin, T.L.; Moir, D.T.
Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay
Antimicrob. Agents Chemother.
59
5775-5787
2015
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Van Dolah, F.; Zippay, M.; Pezzolesi, L.; Rein, K.; Johnson, J.; Morey, J.; Wang, Z.; Pistocchi, R.
Subcellular localization of dinoflagellate polyketide synthases and fatty acid synthase activity
J. Phycol.
49
1118-1127
2013
Karenia brevis, Karenia brevis Gerd Hansen
Manually annotated by BRENDA team
Runguphan, W.; Keasling, J.
Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals
Metab. Eng.
21
103-113
2014
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Manually annotated by BRENDA team
Henritzi, S.; Fischer, M.; Grininger, M.; Oreb, M.; Boles, E.
An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae
Biotechnol. Biofuels
11
150
2018
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H.; Tittmann, K.; Stark, H.; Chari, A.
Discovery of a regulatory subunit of the yeast fatty acid synthase
Cell
180
1130-1143
2020
Saccharomyces cerevisiae (P07149 and P19097 and Q12513), Saccharomyces cerevisiae ATCC 204508 (P07149 and P19097 and Q12513)
Manually annotated by BRENDA team
Wernig, F.; Boles, E.; Oreb, M.
De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae
Metab. Eng. Commun.
10
e00111
2020
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gajewski, J.; Buelens, F.; Serdjukow, S.; Janssen, M.; Cortina, N.; Grubmueller, H.; Grininger, M.
Engineering fatty acid synthases for directed polyketide production
Nat. Chem. Biol.
13
363-365
2017
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Gajewski, J.; Pavlovic, R.; Fischer, M.; Boles, E.; Grininger, M.
Engineering fungal de novo fatty acid synthesis for short chain fatty acid production
Nat. Commun.
8
14650
2017
Saccharomyces cerevisiae (P07149 and P19097)
Manually annotated by BRENDA team
Fischer, M.; Joppe, M.; Mulinacci, B.; Vollrath, R.; Konstantinidis, K.; Koetter, P.; Ciccarelli, L.; Vonck, J.; Oesterhelt, D.; Grininger, M.
Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS)
Sci. Rep.
10
895
2020
Saccharomyces cerevisiae (P07149 and P19097), Saccharomyces cerevisiae ATCC 204508 (P07149 and P19097)
Manually annotated by BRENDA team