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2.3.1.48: histone acetyltransferase

This is an abbreviated version!
For detailed information about histone acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.48

Reaction

acetyl-CoA
+
[protein]-L-lysine
=
CoA
 +
[protein]-N6-acetyl-L-lysine

Synonyms

AAPatA, acetyltransferase, histone, Ada2/Ada3/Gcn5 complex, AIB1, amino acid sensing acetyltransferase, AmiPatA, Amir 5672, ARD1, ARD1 acetyltransferase, arginine methyltransferase A, arginine methyltransferase B, arrest defective 1, arrest defective protein 1 acetyltransferase, At3g14980, ATAC2, ATase1, ATase2, cAMP-regulated protein lysine acetyltransferase, Cbp, CBP histone acetyltransferase, CBP/p300, chameau, circadian locomoter output cycles protein kaput, CLOCK, CREB binding protein, CREB-binding protein, CREBBP, east1, ELO3, ELONGATA3, elongator protein 3, ELP3, enhancer-of-asymmetric leaves-two1, Enok, EP300, Esa1, factor acetyltransferase, FAT, Gcn5, GCN5 family KAT, Gcn5 HAT, GCN5 lysine acetyltransferase, GCN5 N acetyltransferase 5, Gcn5 related N-acetyltransferase, GCN5-like acetyltransferase, GCN5-like enzyme, GCN5-related N-acetyltransferase, Gcn5/PCAF histone acetyltransferase, GCN5b, GCN5L2, general control non-derepressible 5, general control non-repressed protein5, general control nonderepressible 5, general control nonrepressed-protein 5, general control of amino acid synthesis 5, GNAT, GNAT-related histone acetyltransferase complex, GTF3C4, H4 lysine acetyltransferase, HAC1, HAG1, HAG3, HAG4, HAG5, HAM1, HAM2, hARD1, HAT, HAT-B, HAT-B complex, Hat1, Hat1p, Hat2, HatB3.I, HBO1, histone (H4 K16) acetyltransferase, histone acetokinase, histone acetyl transferase, histone acetylase, histone acetyltransferase, histone acetyltransferase 1, histone acetyltransferase AtGCN5, histone acetyltransferase B, histone acetyltransferase Tip60, histone acetyltransferase-1, histone acetyltransferases, histone H3 acetyltransferase, histone H4 acetyltransferase, histone H4 lysine 16 acetyltransferase, histone transacetylase, histone/protein lysine acetyltransferase, HIV-1 Tat-interactive protein, hMOF, Hpa2, Hpa3, human acetylase binding to ORC1, Idm1, K (lysine) acetyltransferase 8, K(lysine) acetyltransferase 8, KAT, KAT10, KAT11, KAT12, KAT13A, KAT13B, KAT13C, KAT13D, KAT2, Kat2A, KAT2A/GCN5, Kat2b, KAT3A, KAT3B, KAT4, KAT5, KAT6, KAT6A, KAT6B, KAT7, KAT8, KAT9, Lsy-12, lysine acetyltransferase, lysine acetyltransferase 2, lysine acetyltransferase 2A, lysine acetyltransferase 2B, lysine acetyltransferase 5, lysine acetyltransferase 8, lysine acetyltransferase complex, lysine acetyltransferase p300, lysine acetyltransferases, lysine-acetyltransferase, Mof, monocytic leukemia zinc finger, monocytic leukemia zinc finger protein, More, Morf, MORF histone acetyltransferase, MOZ, MOZ histone acetyltransferase, Moz related factor, Mst1, MtPat, Myb-binding protein 1A, MYBBP1A, MYST, MYST protein lysine acetyltransferase, MYST-related histone acetyltransferase complex, MYST1, MYST2, MYST3, MYST4, N(alpha)-acetyltransferase 10, N-acetyltransferase, N-terminal acetyltransferase, NAA10, NAT, NAT4, NCoA-1, NCoA-3, NCOAT, Nepsilon-lysine acetyltransferase, NuA4, NuA4 histone acetyltransferase, nuclear cytoplasmicO-GlcNAcase and acetyltransferase, nuclear receptor coactivator 1, nuclear receptor coactivator 3, nucleosome-histone acetyltransferase, Nut1, p/CAF, P/CAF histone acetyltransferase, p160, p300, p300 HAT, p300 histone acetyltransferase, p300/CBP, p300/CBP associated factor, p300/CBP histone acetyltransferase, P300/CBP-associated factor, p300/CBP-associated factor (pCAF), p300HAT, PA4534, Pat, PCAF, PCAF histone acetyltransferase, PF11_0192, PfGCN5, PfGCN5 HAT, Piccolo NuA4 complex, protein acetyl-transferase, protein acetyltransferase, Qkf, regulator of Ty1 transposition protein 109, RmtA, RmtB, RPD3, Rtt109, Rv0998, SAS complex, Sas2, Sas3, SRC1, SRC3, Sven 0867, SvePatA, TAF, TAF1, Tat interacting protein of 60 kDa, Tat-interactive protein, 60 kDa, TBP1, TFIIIC90, tGCN5, TgGCN5b, TgMYST-B, Tip60, tumor suppressor histone H3 lysine 23 acetyltransferase, type B histone acetyltransferase, YfmK, zMoz

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.48 histone acetyltransferase

IC50 Value

IC50 Value on EC 2.3.1.48 - histone acetyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0023
(2E,6E)-2,6-bis[(3,5-dibromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one
Homo sapiens
at pH 8.0 and 30°C
0.0389
(2E,6E)-2,6-bis[(3-fluoro-4-hydroxyphenyl)methylidene]cyclohexan-1-one
Homo sapiens
at pH 8.0 and 30°C
0.0268
(2E,6E)-2,6-bis[(4-hydroxy-3-methylphenyl)methylidene]cyclohexan-1-one
Homo sapiens
at pH 8.0 and 30°C
0.035
(3Z,5Z)-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]thian-4-one
Homo sapiens
at pH 8.0 and 30°C
0.00047
(4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)phenyl)phosphonic acid
Homo sapiens
at pH 8.0 and 25°C
0.32
(4E)-2-(4-acetylphenyl)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Homo sapiens
pH and temperature not specified in the publication
0.0077
(E)-4-(2-(5,6-dimethylbenzo[d]thiazol-2-yl)vinyl)-N,N-diethylbenzenesulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.03
(E)-4-(2-(5-bromobenzo[d]thiazol-2-yl)vinyl)-N,N-diethylbenzenesulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.03
(E)-4-(2-(5-chlorobenzo[d]thiazol-2-yl)vinyl)-N,N-diethylbenzenesulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.006
(E)-4-(2-(benzo[d]thiazol-2-yl)vinyl)-N,N-diethylbenzenesulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.04
(E)-N,N-diethyl-4-(2-(5-fluorobenzo[d]thiazol-2-yl)vinyl)benzenesulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.005
1,7-bis(3-bromo-4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
Homo sapiens
-
-
0.0071
2'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00062
2'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0082
2'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00023
2,3-difluoro-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00018
2,4-difluoro-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0309 - 0.033
2,6-bis(3-bromo-4-hydroxybenzylidene)cyclohexanone
0.0455
2,6-bis(3-chloro-4-hydroxybenzylidene)cyclohexan-1-one
Homo sapiens
at pH 8.0 and 30°C
0.0081
2,6-bis(4-hydroxy-3-iodobenzylidene)cyclohexan-1-one
Homo sapiens
at pH 8.0 and 30°C
0.00018
2,6-difluoro-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00731
2-(3,5-difluoro-4-hydroxyphenyl)-4-((5-(4,5-dimethyl-2-(trifluoromethyl)phenyl)furan-2-yl)methylene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Homo sapiens
at pH 8.0 and 25°C
0.0048
2-(3,5-difluoro-4-hydroxyphenyl)-4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Homo sapiens
at pH 8.0 and 25°C
0.01
2-(3,5-difluoro-4-hydroxyphenyl)-5-methyl-4-((5-(2-(trifluoromethoxy)phenyl)furan-2-yl)methylene)-2,4-dihydro-3H-pyrazol-3-one
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.00373 - 0.00605
2-(3,5-difluoro-4-hydroxyphenyl)-5-methyl-4-((5-(3-oxo-2,3-dihydro-1H-inden-4-yl)furan-2-yl)methylene)-2,4-dihydro-3H-pyrazol-3-one
0.0024
2-(3-fluoro-5-(2-((2-fluorophenyl)sulfonyl)hydrazinecarbonyl)-phenyl)pyridine 1-Oxide
Homo sapiens
pH and temperature not specified in the publication
0.00503
2-(3-methoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
Homo sapiens
-
substrate histone H3 peptide, pH 7.5, 30°C
0.00067
2-(4-(2H-tetrazol-5-yl)phenyl)-4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Homo sapiens
at pH 8.0 and 25°C
0.0255 - 0.13
2-(4-(trifluoromethyl)benzyl)isothiazolo[5,4-b]pyridin-3(2H)-one
0.00072 - 0.00164
2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
0.00463
2-(4-methylphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
Homo sapiens
-
substrate histone H3 peptide, pH 7.5, 30°C
0.125
2-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.0073
2-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00053
2-fluoro-3-hydroxy-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00039
2-fluoro-3-methyl-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00012
2-fluoro-4-methyl-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00023
2-fluoro-5-hydroxy-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000073
2-fluoro-5-methoxy-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000096
2-fluoro-5-methyl-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00011
2-fluoro-6-methoxy-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000062
2-fluoro-N'-(2-fluoro-5-methyl-3-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000044
2-fluoro-N'-(2-fluoro-5-methyl-3-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00169
2-fluoro-N'-(2-phenylisonicotinoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000018
2-fluoro-N'-(3-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000029
2-fluoro-N'-(3-(4-fluoro-1H-pyrazol-1-yl)-5-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00034
2-fluoro-N'-(3-(4-fluoro-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0003
2-fluoro-N'-(3-(4-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00002
2-fluoro-N'-(3-(furan-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000006
2-fluoro-N'-(3-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000025
2-fluoro-N'-(3-(thiophen-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000014
2-fluoro-N'-(3-(thiophen-3-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00027
2-fluoro-N'-(3-fluoro-5-(1H-pyrazol-1-yl)benzoyl)-3-methoxybenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00035
2-fluoro-N'-(3-fluoro-5-(1H-pyrazol-1-yl)benzoyl)-4-methoxybenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000026
2-fluoro-N'-(3-fluoro-5-(1H-pyrazol-1-yl)benzoyl)-5-hydroxybenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0001
2-fluoro-N'-(3-fluoro-5-(1H-pyrazol-1-yl)benzoyl)-5-methoxybenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000009
2-fluoro-N'-(3-fluoro-5-(2H-1,2,3-triazol-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000023
2-fluoro-N'-(3-fluoro-5-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000032
2-fluoro-N'-(3-fluoro-5-(4-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000031
2-fluoro-N'-(3-fluoro-5-(5-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00027
2-fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)-3-hydroxybenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0000063
2-fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00006
2-fluoro-N'-(3-iodobenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000017 - 0.08
2-fluoro-N'-(3-isobutoxybenzoyl)benzenesulfonohydrazide
0.059
2-fluoro-N'-(3-isopropoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00097
2-fluoro-N'-(3-isopropylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000013
2-fluoro-N'-(3-methoxy-5-(1H-pyrazol-1-yl)benzoyl)-benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000203
2-fluoro-N'-(3-methoxy-5-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000024
2-fluoro-N'-(3-methoxy-5-(pyrimidin-2-yl)benzoyl)-benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000027
2-fluoro-N'-(3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000018
2-fluoro-N'-(3-methyl-5-(2H-1,2,3-triazol-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000007
2-fluoro-N'-(3-methyl-5-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000014
2-fluoro-N'-(3-methyl-5-(4-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000013
2-fluoro-N'-(3-methyl-5-(5-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00038
2-fluoro-N'-(3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.094
2-fluoro-N'-(3-propoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000094
2-fluoro-N'-(3-propylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00235
2-fluoro-N'-(5-phenylnicotinoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0029
2-fluoro-N'-(6-phenylpicolinoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.001
2-fluoro-N'-(naphthalene-2-sulfonyl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0018
2-fluoro-N'-(phenylsulfonyl)benzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0041 - 0.0057
2-fluoro-N'-[(3-fluorophenyl)sulfonyl]benzohydrazide
0.0044
2-fluoro-N'-[[3-(trifluoromethyl)phenyl]sulfonyl]benzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.049
2-hydroxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.01
2-tert-butyl-5-(dodecylthio)isothiazol-3(2H)-one-1-oxide
Homo sapiens
-
above
0.01
2-tert-butyl-5-chloroisothiazol-3(2H)-one 1-oxide
Homo sapiens
-
above
0.015
2-[2-(4-heptylphenyl)ethyl]-6-hydroxybenzoic acid
Homo sapiens
at pH 7.5 and 25°C
0.00079
3'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0034
3'-cyano-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.011
3'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.009
3'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.012
3-(2-(2-fluorobenzoyl)hydrazinylsulfono)benzamide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00049
3-amino-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0036
3-bromo-N'-(3-ethoxybenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0017
3-chloro-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00052
3-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.014
3-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000023
3-fluoro-N'-(2-fluorobenzene-1-sulfonyl)-5-(1H-pyrazol-1-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0000094
3-fluoro-N'-(2-fluorobenzene-1-sulfonyl)-5-(furan-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000014
3-fluoro-N'-(2-fluorobenzene-1-sulfonyl)-5-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0013
3-fluoro-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0014
3-methyl-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.004
4'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.041
4'-cyano-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0095
4'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0258
4'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0024
4,5-dichloro-2-ethylisothiazol-3(2H)-one
Homo sapiens
-
-
0.01
4,5-dichloro-2-ethylisothiazol-3(2H)-one-1-oxide
Homo sapiens
-
above
0.00406
4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-5-methyl-2-(4-(methylsulfonyl)phenyl)-2,4-dihydro-3H-pyrazol-3-one
Homo sapiens
at pH 8.0 and 25°C
0.00016
4-(3-cyclopropyl-4-((5-(4,5-dimethyl-2-(trifluoromethyl)phenyl)thiophen- 2-yl)methylene)-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.0002
4-(3-cyclopropyl-4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00056
4-(3-methyl-4-((5-(2-nitrophenyl)furan-2-yl)methylene)-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00113
4-(3-methyl-5-oxo-4-((5-(2-(trifluoromethoxy)phenyl)furan-2-yl)methylene)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00058
4-(3-methyl-5-oxo-4-((5-(3-oxo-2,3-dihydro-1H-inden-4-yl)furan-2-yl)methylene)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00086
4-(4-((2-(4,5-dimethyl-2-nitrophenyl)thiazol-5-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00117
4-(4-((5-(2-(difluoromethyl)phenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.01
4-(4-((5-(2-(dimethylphosphoryl)phenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.00029
4-(4-((5-(4,5-dimethyl-2-(trifluoromethyl)phenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00195
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-1H-pyrrol-2-yl)methylene)-3-methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.01
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-2,5-dioxoimidazolidin-1-yl)benzoic acid
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.00019
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-ethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00023
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 37°C
0.00153
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzonitrile
Homo sapiens
at pH 8.0 and 25°C
0.00023
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)thiophen-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00207
4-(4-(1-(5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)ethylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.00961
4-(4-(2-((4,5-dimethyl-2-nitrophenyl)amino)-2-oxoethyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.01
4-(4-(3-((4,5-dimethyl-2-nitrophenyl)amino)-3-oxopropyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.01
4-(5-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-2,4- dioxothiazolidin-3-yl)benzoic acid
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.01
4-(5-(4,5-dimethyl-2-nitrobenzoyl)-1H-indazol-1-yl)benzoic acid
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.01
4-(5-(4,5-dimethyl-2-nitrobenzoyl)-1H-indol-1-yl)benzoic acid
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.01
4-(5-(4,5-dimethyl-2-nitrobenzyl)-1H-indazol-1-yl)benzoic acid
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 25°C
0.00713
4-([(2E)-2-cyano-3-[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]prop-2-enoyl]amino)benzoic acid
Homo sapiens
at pH 8.0 and 25°C
0.0097
4-amino-1-naphthol
Homo sapiens
pH and temperature not specified in the publication
0.0125
4-amino-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.125
4-butoxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.06
4-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.0125
4-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.03
4-hydroxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.0141
4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]-N-(prop-2-yn-1-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0068
4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.00053
5-bromo-N'-(3-ethoxybenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.01
5-chloro-2-ethyl-4-methylisothiazol-3(2H)-one
Homo sapiens
-
above
0.01
5-chloro-2-ethyl-4-methylisothiazol-3(2H)-one-1-oxide
Homo sapiens
-
above
0.003
5-chloro-2-ethylisothiazol-3(2H)-one
Homo sapiens
-
-
0.01
5-chloro-2-ethylisothiazol-3(2H)-one-1-oxide
Homo sapiens
-
above
0.0000026 - 0.0000098
A-485
0.00033 - 0.0038
Ac-ARTK(me)QTARK(me)3STGGK(CoA)APRKQL
0.0011 - 0.0345
Ac-ARTK(me)QTARKSTGGK(CoA)APRKQL
0.00028 - 0.0012
Ac-ARTKQTARK(me)3STGGK(Sme)APRKQL
0.00035 - 0.009
Ac-ARTKQTARKSTGGK(Br)APRKQL
0.0084 - 0.0091
Ac-ARTKQTARKSTGGK(CoA)APRKQL
0.0749
Ac-L-Lys(CoA)-NH2
Homo sapiens
at pH 8.0 and 30°C
0.026 - 0.348
anacardic acid
0.0016
C646
Homo sapiens
pH and temperature not specified in the publication
0.0022 - 0.0073
CCT077791
Homo sapiens
-
IC50: 0.0022-0.0073 mM, in vivo cell proliferation inhibition, reduces acetylation of histones H3 and H4 and alpha-tubulin in cancer cell lines
0.0027 - 0.015
CCT077792
Homo sapiens
-
IC50: 0.0027-0.015 mM, in vivo cell proliferation inhibition
0.0187 - 0.0202
CCT077796
Homo sapiens
-
IC50: 0.0187-0.0202 mM, in vivo cell proliferation inhibition
0.0547
CCT079769
Homo sapiens
-
IC50: 0.0547 mM, in vivo cell proliferation inhibition
0.0415
CoA
Homo sapiens
at pH 8.0 and 30°C
0.001 - 0.012
CTX-0124143
0.025 - 0.4
curcumin
0.0072
embelin
Homo sapiens
pH and temperature not specified in the publication
0.0011 - 0.0029
EML425
0.03 - 0.07
epigallocatechin-3-gallate
0.0575
ethyl 2-methyl-6-([5-[(prop-2-yn-1-yl)amino]pentyl]oxy)quinoline-3-carboxylate
Homo sapiens
pH and temperature not specified in the publication
0.005 - 0.007
garcinol
0.034 - 0.064
H3-CoA-20
Homo sapiens
-
IC50: 0.034-0.064 mM
0.012
H3-CoA-20-Tat
Homo sapiens
-
IC50: 0.012 mM, recombinant enzyme
-
0.002 - 0.128
L002
0.0001 - 0.2
Lys-CoA
0.00025
Lys-CoA-Tat
Homo sapiens
-
IC50: 250 nM, recombinant enzyme, complete inhibition of acetylation of the promyelotic leukemia zinc finger gene
0.1
MB-3
Homo sapiens
pH and temperature not specified in the publication
0.01
methyl 3-(4,5-dichloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate
Homo sapiens
-
above
0.0026
methyl 3-(4,5-dichloro-3-oxoisothiazol-2(3H)-yl)propanoate
Homo sapiens
-
-
0.0056
methyl 3-(5-chloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate
Homo sapiens
-
-
0.0018
methyl 3-(5-chloro-3-oxoisothiazol-2(3H)-yl)propanoate
Homo sapiens
-
-
0.01
methyl 3-(5-chloro-4-methyl-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate
Homo sapiens
-
above
0.01
methyl 3-(5-chloro-4-methyl-3-oxoisothiazol-2(3H)-yl)propanoate
Homo sapiens
-
above
0.01
methyl 3-[4-chloro-5-(dodecylthio)-1-oxido-3-oxoisothiazol-2(3H)-yl]propanoate
Homo sapiens
-
above
0.01
methyl 3-[5-(dodecylthio)-1-oxido-3-oxoisothiazol-2(3H)-yl] propanoate
Homo sapiens
-
above
0.00027
N'-( 2-fluoro-[1,1'- biphenyl]-3-carbonyl)-benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00074
N'-(2,3-difluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00013
N'-(2,3-difluorobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000072
N'-(2,6-difluorobenzene-1-sulfonyl)-3-fluoro-5-propoxybenzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000061
N'-(2,6-difluorobenzene-1-sulfonyl)-3-fluoro-5-[(propan-2-yl)oxy]benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00011
N'-(2,6-difluorobenzene-1-sulfonyl)-3-methoxy-5-[(propan-2-yl)oxy]benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000015
N'-(2,6-difluorobenzene-1-sulfonyl)-3-methyl-5-[(propan-2-yl)oxy]benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0125
N'-(2-dluorobenzoyl)-4-methylbenzenesulfonohydrazide
Mus musculus
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00039
N'-(2-fluoro-3-(trifluoromethyl)benzoyl)-benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000077
N'-(2-fluoro-3-(trifluoromethyl)benzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00049
N'-(2-fluoro-3-methoxybenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000017
N'-(2-fluoro-3-methyl-5-((2-methylallyl)oxy)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000078
N'-(2-fluoro-3-methyl-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000096
N'-(2-fluoro-3-methyl-5-(2H-1,2,3-triazol-2-yl)benzoyl)-naphthalene-2-sulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000065
N'-(2-fluoro-3-methyl-5-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000084
N'-(2-fluoro-3-methyl-5-(4-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000087
N'-(2-fluoro-3-methyl-5-(5-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00023
N'-(2-fluoro-3-methylbenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00012
N'-(2-fluoro-3-methylbenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00014
N'-(2-fluoro-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00034
N'-(2-fluoro-5-(2H-1,2,3-triazol-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00016
N'-(2-fluoro-5-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000052
N'-(2-fluoro-5-(4-fluoro-1H-pyrazol-1-yl)-3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00022
N'-(2-fluoro-5-(4-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00008
N'-(2-fluoro-5-(furan-2-yl)-3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00012
N'-(2-fluoro-5-(furan-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00009
N'-(2-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000063
N'-(2-fluoro-5-isopropoxy-3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000062
N'-(2-fluoro-5-isopropoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00091
N'-(2-fluoro-5-methylbenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000081
N'-(2-fluoro-5-propoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00011
N'-(2-fluorobenzene-1-sulfonyl)-3-(furan-2-yl)-5-methoxybenzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000011
N'-(2-fluorobenzene-1-sulfonyl)-3-(furan-2-yl)-5-methylbenzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00023
N'-(2-fluorobenzene-1-sulfonyl)-3-(naphthalen-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000054
N'-(2-fluorobenzene-1-sulfonyl)-3-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0019
N'-(2-fluorobenzene-1-sulfonyl)-3-(pyrimidin-4-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.56
N'-(2-fluorobenzene-1-sulfonyl)-3-(trifluoromethoxy)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000005
N'-(2-fluorobenzene-1-sulfonyl)-3-methoxy-5-(pyridin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000008
N'-(2-fluorobenzene-1-sulfonyl)-3-methyl-5-(pyridin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000009
N'-(2-fluorobenzene-1-sulfonyl)-3-methyl-5-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.8
N'-(2-fluorobenzene-1-sulfonyl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.017
N'-(2-fluorobenzoyl)-2-methoxybenzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0062
N'-(2-fluorobenzoyl)-2-methylbenzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0011
N'-(2-fluorobenzoyl)-3-methoxybenzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0035
N'-(2-fluorobenzoyl)-3-methylbenzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0125
N'-(2-fluorobenzoyl)-4-methoxybenzenesulfonohydrazide
Mus musculus
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.042
N'-(2-methoxybenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.019
N'-(2-methylbenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.019
N'-(2-phenylisonicotinoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00049
N'-(3-(1,2,4-oxadiazol-3-yl)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00463
N'-(3-(1,3,4-oxadiazol-2-yl)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000043
N'-(3-(1H-pyrazol-1-yl)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00061 - 0.125
N'-(3-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
0.00018
N'-(3-(3,5-dimethyl-1H-pyrazol-1-yl)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0006
N'-(3-(4-fluoro-1H-pyrazol-1-yl)-5-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00002
N'-(3-(allyloxy)-5-fluorobenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000016
N'-(3-(allyloxy)-5-methylbenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.03
N'-(3-(allyloxy)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.23
N'-(3-(cyclopentyloxy)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00044
N'-(3-(cyclopentyloxy)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000091 - 0.00011
N'-(3-(cyclopropylmethoxy)-5-fluorobenzoyl)-2-fluorobenzenesulfonohydrazide
0.00009
N'-(3-(cyclopropylmethoxy)-5-methylbenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.12
N'-(3-(cyclopropylmethoxy)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000024
N'-(3-(ethoxymethyl)-5-methylbenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00048
N'-(3-(furan-2-yl)-5-methoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00013
N'-(3-(furan-2-yl)-5-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0074
N'-(3-(piperazin-1-yl)benzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00014
N'-(3-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.125
N'-(3-(pyridin-3-yl)benzoyl)benzenesulfonohydrazide
Mus musculus
IC50 above 0.125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00063
N'-(3-(pyrimidin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.029 - 0.125
N'-(3-(pyrimidin-5-yl)benzoyl)benzenesulfonohydrazide
0.00016
N'-(3-(thiazol-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00027
N'-(3-(thiazol-4-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00016
N'-(3-(thiophen-2-yl)benzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.013
N'-(3-(thiophen-3-yl)benzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.01
N'-(3-(trifluoromethoxy)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0028
N'-(3-(trifluoromethoxy)benzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.011
N'-(3-(trifluoromethyl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.011
N'-(3-(trifluoromethyl)benzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.125
N'-(3-acetylbenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.019
N'-(3-aminobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.00018
N'-(3-bromobenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.23
N'-(3-butoxybenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.003
N'-(3-butoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00013
N'-(3-chloro-2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000043
N'-(3-chloro-2-fluorobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0000055
N'-(3-chloro-5-(furan-2-yl)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00011
N'-(3-chloro-5-(furan-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000024
N'-(3-chloro-5-(thiophen-2-yl)benzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.024
N'-(3-cyanobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000027
N'-(3-cyclopropoxy-5-methylbenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00011
N'-(3-ethoxy-5-fluorobenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00016
N'-(3-ethoxy-5-methoxybenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00017
N'-(3-ethoxy-5-methylbenzoyl)-2,3-difluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00013
N'-(3-ethoxy-5-methylbenzoyl)-2,4-difluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00017
N'-(3-ethoxy-5-methylbenzoyl)-2,5-difluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00013
N'-(3-ethoxy-5-methylbenzoyl)-2,6-difluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00016
N'-(3-ethoxy-5-methylbenzoyl)-2-fluoro-3-methylbenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00018
N'-(3-ethoxy-5-methylbenzoyl)-2-fluoro-4-methylbenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00012
N'-(3-ethoxy-5-methylbenzoyl)-2-fluoro-5-methylbenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000016
N'-(3-ethoxy-5-methylbenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00027
N'-(3-ethoxybenzoyl)-2-fluoro-5-methoxybenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.005
N'-(3-ethoxybenzoyl)-2-fluoro-6-methoxybenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.069
N'-(3-ethoxybenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00037
N'-(3-ethoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00057
N'-(3-ethoxybenzoyl)naphthalene-2-sulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00058
N'-(3-ethyl-2-fluorobenzoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000062
N'-(3-ethyl-2-fluorobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00022
N'-(3-ethylbenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0036
N'-(3-ethylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00044
N'-(3-fluoro-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00043
N'-(3-fluoro-5-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0008
N'-(3-fluoro-5-(4-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00014
N'-(3-fluoro-5-(furan-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0001
N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0004
N'-(3-fluoro-5-propoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0021
N'-(3-fluorobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00024
N'-(3-isobutoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00033
N'-(3-isopropoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0062
N'-(3-isopropylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0078
N'-(3-isopropylbenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0012
N'-(3-methoxy-5-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00039
N'-(3-methoxy-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00069
N'-(3-methoxybenzoyl)naphthalene-2-sulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.018
N'-(3-methoxylbenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.0023
N'-(3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0047
N'-(3-phenoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00038
N'-(3-propoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00012
N'-(3-propoxybenzoyl)naphthalene-2-sulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0033
N'-(3-propylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.125
N'-(4-(trifluoromethoxy)benzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.125
N'-(4-cyanobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.000008
N'-(4-fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000017
N'-(4-fluoro-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.12
N'-(4-fluorobenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.12
N'-(4-methoxybenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.03
N'-(4-methylbenzoyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.000061
N'-(5-(allyloxy)-2-fluoro-3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00007
N'-(5-(allyloxy)-2-fluorobenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000054
N'-(5-(cyclopropylmethoxy)-2-fluoro-3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000029
N'-(5-(ethoxymethyl)-2-fluoro-3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00001
N'-(5-chloro-4-fluoro-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000074
N'-(5-ethoxy-2-fluoro-3-methylbenzoyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000082
N'-(5-ethoxy-2-fluoro-3-methylbenzoyl)naphthalene-2-sulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00019
N'-(5-ethoxy-2-fluorobenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.022
N'-(5-phenylnicotinoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.018
N'-(6-phenylpicolinoyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000073
N'-(benzenesulfonyl)-2-fluoro-3-methyl-5-(pyridin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000067
N'-(benzenesulfonyl)-2-fluoro-3-methyl-5-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00014
N'-(benzenesulfonyl)-2-fluoro-5-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.125
N'-(benzenesulfonyl)-2-fluoro-5-(pyrimidin-4-yl)benzohydrazide
Homo sapiens
above, pH and temperature not specified in the publication
0.00012
N'-(benzenesulfonyl)-2-fluoro-5-[(prop-2-yn-1-yl)oxy]benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00045
N'-(benzenesulfonyl)-3-fluoro-5-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0072
N'-(benzenesulfonyl)-3-fluorobenzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00067
N'-(benzenesulfonyl)-3-methoxy-5-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0023
N'-(benzenesulfonyl)-3-methoxybenzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00023
N'-(benzenesulfonyl)-3-methyl-5-(pyrimidin-2-yl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000062
N'-(ethoxy-2-fluoro-3-methylbenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0042
N'-(naphthalen-2-ylsulfonyl)benzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0042
N'-(naphthalene-2-sulfonyl)benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00014
N'-([1,1'-biphenyl]-3-carbonyl)-2-fluorobenzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.00029
N'-([1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00088
N'-([1,1'-biphenyl]-3-carbonyl)naphthalene-2-sulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.0067
N'-benzoylbenzenesulfonohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.001
N'-[(3-bromophenyl)sulfonyl]-2-fluorobenzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.019
N'-[(3-ethylphenyl)sulfonyl]-2-fluorobenzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.00046
N'-[(4-bromophenyl)sulfonyl]-2-fluorobenzohydrazide
Mus musculus
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication
0.000038
N-(2-fluoro-3-methyl-5-(2H-1,2,3-triazol-2-yl)benzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.000052
N-(2-fluoro-3-methyl-5-propoxybenzoyl)benzenesulfonohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.0041
N-[5-[(5-[[5-([4-[(5-[[5-([5-[(5-[[3-(dimethylamino)propyl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)carbamoyl]-1-methyl-1H-pyrrol-3-yl]carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)amino]-4-oxobutyl]carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)carbamoyl]-1-methyl-1H-pyrrol-3-yl]-4-[(N-[[2-(2-[4-[(4Z)-4-[[5-(2,3-dimethyl-6-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzamido]ethoxy)ethoxy]acetyl]-beta-alanyl)amino]-1-methyl-1H-pyrrole-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000011
NK13650A
Homo sapiens
pH and temperature not specified in the publication
0.000022
NK13650B
Homo sapiens
pH and temperature not specified in the publication
0.002
NU9056
Homo sapiens
pH and temperature not specified in the publication
0.00007
peptide conjugate Boc-C5-CoA
Homo sapiens
pH and temperature not specified in the publication
-
0.0003
peptide conjugate H3-CoA-20
Homo sapiens
pH and temperature not specified in the publication
-
0.00662 - 0.01759
peptide conjugate H4-K16-CoA
-
0.002 - 0.02
Plumbagin
0.0016 - 0.00974
PU139
0.071
tert-butyl-(3-(2-(naphthalen-2-ylsulfono)hydrazinecarbonyl)-phenyl)carbamate
Mus musculus
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication
0.000002
WM-1119
Mus musculus
pH and temperature not specified in the publication
0.000008
WM-8014
Mus musculus
pH and temperature not specified in the publication
0.000023
[histone H4]-L-lysine12-CoA
Homo sapiens
at pH 8.0 and 30°C
-
0.0072
[histone H4]-L-lysine16-CoA
Homo sapiens
at pH 8.0 and 30°C
-
0.000083
[histone H4]-L-lysine5-CoA
Homo sapiens
at pH 8.0 and 30°C
-
0.0026
[histone H4]-L-lysine8-CoA
Homo sapiens
at pH 8.0 and 30°C
-
additional information
additional information
-