Cloned (Comment) | Organism |
---|---|
expression of the GST-tagged enzyme in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CCT004463 | in vivo cell proliferation inhibition | Homo sapiens | |
CCT004464 | in vivo cell proliferation inhibition | Homo sapiens | |
CCT004465 | in vivo cell proliferation inhibition | Homo sapiens | |
CCT004466 | in vivo cell proliferation inhibition | Homo sapiens | |
CCT004467 | in vivo cell proliferation inhibition | Homo sapiens | |
CCT077791 | IC50: 0.0022-0.0073 mM, in vivo cell proliferation inhibition, reduces acetylation of histones H3 and H4 and alpha-tubulin in cancer cell lines | Homo sapiens | |
CCT077792 | IC50: 0.0027-0.015 mM, in vivo cell proliferation inhibition | Homo sapiens | |
CCT077796 | IC50: 0.0187-0.0202 mM, in vivo cell proliferation inhibition | Homo sapiens | |
CCT079769 | IC50: 0.0547 mM, in vivo cell proliferation inhibition | Homo sapiens | |
H3-CoA-20 | IC50: 0.034-0.064 mM | Homo sapiens | |
isothiazolone | binds irreversibly to proteins via thiol interactions | Homo sapiens | |
Lys-CoA | IC50: 310-420 nM | Homo sapiens | |
additional information | inhibitory potency of N-substituted isothiazolone-based compounds, in vivo cell proliferation inhibition, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 + acetyl-CoA | Homo sapiens | acetylation of Lys9, and Lys14 | acetyl-histone H3 + CoA | - |
? | |
histone H4 + acetyl-CoA | Homo sapiens | - |
acetyl-histone H4 + CoA | - |
? | |
additional information | Homo sapiens | deregulated HAT activity plays a role in the development of a range of cancers | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | colon tumor cell line | Homo sapiens | - |
HT-29 cell | colon tumor cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 + acetyl-CoA | acetylation of Lys9, and Lys14 | Homo sapiens | acetyl-histone H3 + CoA | - |
? | |
histone H4 + acetyl-CoA | - |
Homo sapiens | acetyl-histone H4 + CoA | - |
? | |
histone H4 + acetyl-CoA | acetylation of Lys5, Lys8, and Lys12 | Homo sapiens | acetyl-histone H4 + CoA | - |
? | |
additional information | deregulated HAT activity plays a role in the development of a range of cancers | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
p300 HAT | - |
Homo sapiens |
p300 histone acetyltransferase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00031 | 0.00042 | IC50: 310-420 nM | Homo sapiens | Lys-CoA | |
0.0022 | 0.0073 | IC50: 0.0022-0.0073 mM, in vivo cell proliferation inhibition, reduces acetylation of histones H3 and H4 and alpha-tubulin in cancer cell lines | Homo sapiens | CCT077791 | |
0.0027 | 0.015 | IC50: 0.0027-0.015 mM, in vivo cell proliferation inhibition | Homo sapiens | CCT077792 | |
0.0187 | 0.0202 | IC50: 0.0187-0.0202 mM, in vivo cell proliferation inhibition | Homo sapiens | CCT077796 | |
0.034 | 0.064 | IC50: 0.034-0.064 mM | Homo sapiens | H3-CoA-20 | |
0.0547 | - |
IC50: 0.0547 mM, in vivo cell proliferation inhibition | Homo sapiens | CCT079769 |