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2.3.1.48: histone acetyltransferase

This is an abbreviated version!
For detailed information about histone acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.48

Reaction

acetyl-CoA
+
[protein]-L-lysine
=
CoA
 +
[protein]-N6-acetyl-L-lysine

Synonyms

AAPatA, acetyltransferase, histone, Ada2/Ada3/Gcn5 complex, AIB1, amino acid sensing acetyltransferase, AmiPatA, Amir 5672, ARD1, ARD1 acetyltransferase, arginine methyltransferase A, arginine methyltransferase B, arrest defective 1, arrest defective protein 1 acetyltransferase, At3g14980, ATAC2, ATase1, ATase2, cAMP-regulated protein lysine acetyltransferase, Cbp, CBP histone acetyltransferase, CBP/p300, chameau, circadian locomoter output cycles protein kaput, CLOCK, CREB binding protein, CREB-binding protein, CREBBP, east1, ELO3, ELONGATA3, elongator protein 3, ELP3, enhancer-of-asymmetric leaves-two1, Enok, EP300, Esa1, factor acetyltransferase, FAT, Gcn5, GCN5 family KAT, Gcn5 HAT, GCN5 lysine acetyltransferase, GCN5 N acetyltransferase 5, Gcn5 related N-acetyltransferase, GCN5-like acetyltransferase, GCN5-like enzyme, GCN5-related N-acetyltransferase, Gcn5/PCAF histone acetyltransferase, GCN5b, GCN5L2, general control non-derepressible 5, general control non-repressed protein5, general control nonderepressible 5, general control nonrepressed-protein 5, general control of amino acid synthesis 5, GNAT, GNAT-related histone acetyltransferase complex, GTF3C4, H4 lysine acetyltransferase, HAC1, HAG1, HAG3, HAG4, HAG5, HAM1, HAM2, hARD1, HAT, HAT-B, HAT-B complex, Hat1, Hat1p, Hat2, HatB3.I, HBO1, histone (H4 K16) acetyltransferase, histone acetokinase, histone acetyl transferase, histone acetylase, histone acetyltransferase, histone acetyltransferase 1, histone acetyltransferase AtGCN5, histone acetyltransferase B, histone acetyltransferase Tip60, histone acetyltransferase-1, histone acetyltransferases, histone H3 acetyltransferase, histone H4 acetyltransferase, histone H4 lysine 16 acetyltransferase, histone transacetylase, histone/protein lysine acetyltransferase, HIV-1 Tat-interactive protein, hMOF, Hpa2, Hpa3, human acetylase binding to ORC1, Idm1, K (lysine) acetyltransferase 8, K(lysine) acetyltransferase 8, KAT, KAT10, KAT11, KAT12, KAT13A, KAT13B, KAT13C, KAT13D, KAT2, Kat2A, KAT2A/GCN5, Kat2b, KAT3A, KAT3B, KAT4, KAT5, KAT6, KAT6A, KAT6B, KAT7, KAT8, KAT9, Lsy-12, lysine acetyltransferase, lysine acetyltransferase 2, lysine acetyltransferase 2A, lysine acetyltransferase 2B, lysine acetyltransferase 5, lysine acetyltransferase 8, lysine acetyltransferase complex, lysine acetyltransferase p300, lysine acetyltransferases, lysine-acetyltransferase, Mof, monocytic leukemia zinc finger, monocytic leukemia zinc finger protein, More, Morf, MORF histone acetyltransferase, MOZ, MOZ histone acetyltransferase, Moz related factor, Mst1, MtPat, Myb-binding protein 1A, MYBBP1A, MYST, MYST protein lysine acetyltransferase, MYST-related histone acetyltransferase complex, MYST1, MYST2, MYST3, MYST4, N(alpha)-acetyltransferase 10, N-acetyltransferase, N-terminal acetyltransferase, NAA10, NAT, NAT4, NCoA-1, NCoA-3, NCOAT, Nepsilon-lysine acetyltransferase, NuA4, NuA4 histone acetyltransferase, nuclear cytoplasmicO-GlcNAcase and acetyltransferase, nuclear receptor coactivator 1, nuclear receptor coactivator 3, nucleosome-histone acetyltransferase, Nut1, p/CAF, P/CAF histone acetyltransferase, p160, p300, p300 HAT, p300 histone acetyltransferase, p300/CBP, p300/CBP associated factor, p300/CBP histone acetyltransferase, P300/CBP-associated factor, p300/CBP-associated factor (pCAF), p300HAT, PA4534, Pat, PCAF, PCAF histone acetyltransferase, PF11_0192, PfGCN5, PfGCN5 HAT, Piccolo NuA4 complex, protein acetyl-transferase, protein acetyltransferase, Qkf, regulator of Ty1 transposition protein 109, RmtA, RmtB, RPD3, Rtt109, Rv0998, SAS complex, Sas2, Sas3, SRC1, SRC3, Sven 0867, SvePatA, TAF, TAF1, Tat interacting protein of 60 kDa, Tat-interactive protein, 60 kDa, TBP1, TFIIIC90, tGCN5, TgGCN5b, TgMYST-B, Tip60, tumor suppressor histone H3 lysine 23 acetyltransferase, type B histone acetyltransferase, YfmK, zMoz

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.48 histone acetyltransferase

Activating Compound

Activating Compound on EC 2.3.1.48 - histone acetyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3E,5E)-1-ethyl-3,5-bis[(4-hydroxy-3-nitrophenyl)methylidene]piperidin-4-one
128% activity at 0.1 mM
(3E,5E)-3,5-bis[(3,4-dihydroxyphenyl)methylidene]piperidin-4-one
114% activity at 0.1 mM
2-chloro-4-trifluoromethyl benzamide
-
activates the enzyme, the relative position of the -CF3 and -Cl is crucial for p300 HAT activity enhancement, overview
2-dodecylmalonate
-
compound induces hyperacetylation of specific lysine residues of histone H3, in particular residues K9 and K18, and raises the level of pan-acetylated H4. Compound inhibits the acetylation of all the other H3 and H4 lysines, with the exception of residue K8Ac of histone H4
4-chloro-2-trifluoromethyl benzamide
-
activates the enzyme, the relative position of the -CF3 and -Cl is crucial for p300 HAT activity enhancement, overview
Asf1
-
bleomycin
-
activation of the ATM-associated enzyme by bleomycin, the free, non-ATM-associated, Tip60 activity is not activated by bleomycin
BRPF2
-
cAMP
Pat is a cAMP-regulated protein lysine acetyltransferase, that contains an additional nucleotide-binding domain that is structurally similar to the cAMP responsive region of protein kinase A, and inhibits acetyltransferase activity until cAMP is bound
CDT1
-
licensing factor Cdt1 stabilizes HBO1 at origins. HBO1 directly interacts with Cdt1, and it enhances Cdt1-dependent rereplication
-
diethyl 2-pentadecylidenemalonate
-
compound induces hyperacetylation of specific lysine residues of histone H3, in particular residues K9 and K18, and raises the level of pan-acetylated H4
dimethyl-arginine 3-histone H4
-
dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro
-
dithiothreitol
-
10 mM: stimulation, 100 mM: inhibition
DNA
-
enzyme form A activated by low concentration, enzyme form B inhibited
E2F1
the transcription factor associates with and recruits GCN5 to sites of DNA damage. E2F1 is required for the GCN5-mediated regulation of lung cancer cell growth and for theG1/S transition. Cyclin D1 and cyclin E1 are downstream targets of E2F1. GCN5 is enriched at the E2F1-binding site of the cyclin D1, cyclin E1, or E2F1 promoters
-
ethanol
IKKalpha
-
after cytokine stimulation, IKKalpha also phosphorylates CBP at Ser1382 and Ser1386, thus enhancing CBP-binding affinity for p65 and CBP HAT activity and, consequently, histone H3 acetylation
-
laminar shear stress
-
laminar shear stress stimulates acetylation of histones 3 and 4 at the region of the eNOS promoter SSRE and extends 3' toward the eNOS coding region. Laminar shear stress induces p300 binding to p65 and leads to increase of p300 histone acetyltransferase activity by 2.5fold and to increase of acetylation of p65, but not of p50 acetylation, overview
-
LoCAM
i.e. SPV106, 137% activation at 0.05 mM
membrane transporter
-
for acetyl-CoA and acetyltransferase from cytosol into lumen of the ER/ER Golgi intermediate compartment
-
methylated histone
-
stimulates interaction of NuA4 complex with histone
NuA4
-
cooperation with the NuA4 complex to enhance its functions but independent contribution to acetylation
-
p65
-
p65-associated HAT activity. TNFalpha-dependent phosphorylation of p65 at either Ser276 or Ser536 increases its interaction with p300 and its subsequent acetylation at Lys310 of the NFkappaB subunit, indicating that p65 phosphorylation regulates subsequent acetylation
-
SAGA
-
cooperation with the Gcn5 complex to enhance its functions but independent contribution to acetylation
-
Sas4
-
absolutely required for acetylation activity of Sas2 in SAS complex
-
Sas5
-
stimulates acetylation activity of Sas2 in SAS complex
-
spermine
Artemia nauplii
-
activates acetylation of H3
TNF-alpha
-
VPS75
-
Vps75/Asf1
-
helper proteins required by Rtt109 for full catalytic activity. Stimulation of Rtt109 activity by Vps75 results in 50fold increase of the kcat value with unaltered Km
-
Yng2/Epl1
-
helper proteins required by Esa1 for full catalytic activity. Esa1 minimally requires Yng2 and Epl1 for full catalytic activity and nucleosome recognition
-
[(3E,5E)-3,5-bis[(3,4-dihydroxyphenyl)methylidene]-4-oxocyclohexyl]acetic acid
128% activity at 0.1 mM
additional information
-