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2.3.1.16: acetyl-CoA C-acyltransferase

This is an abbreviated version!
For detailed information about acetyl-CoA C-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.16

Reaction

acyl-CoA
+
acetyl-CoA
=
CoA
 +
3-oxoacyl-CoA

Synonyms

2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase, 3-KAT, 3-ketoacyl CoA thiolase, 3-ketoacyl coenzyme A thiolase, 3-ketoacyl coenzyme-A thiolase, 3-ketoacyl thiolase, 3-ketoacyl-CoA thiolase, 3-ketothiolase, 3-oxoacyl-CoA thiolase, 3-oxoacyl-coenzyme A thiolase, 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase, 6-oxoacyl-CoA thiolase, ACAA2, acetoacetyl-CoA beta-ketothiolase, acetyl-CoA acyltransferase, acyl-CoA-thiolase, acyltransferase, acetyl coenzyme A, beta-ketoacyl coenzyme A thiolase, beta-ketoacyl-CoA thiolase, beta-ketoadipyl coenzyme A thiolase, beta-ketoadipyl-CoA thiolase, beta-ketothiolase, BktB, ELo1, Elovl-5, Elovl-6, ELOVL5, Elovl6, enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein, FadA, fatty acid elongase 5, KAT, KAT-1, KAT2, ketoacyl-CoA acyltransferase, ketoacyl-coenzyme A thiolase, long-chain 3-oxoacyl-CoA thiolase, mitochondrial 3-ketoacyl-CoA thiolase, oxoacyl-coenzyme A thiolase, PaaJ, pro-3-ketoacyl-CoA thiolase, PUFA elongase, SCP2/3-oxoacyl-CoA thiolase, SCPx, sterol carrier protein 2/3-oxoacyl-CoA thiolase, TFE-beta subunit, Thb, thiloase B, thiolase A, thiolase I, thiolase II, thiolase III

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.16 acetyl-CoA C-acyltransferase

Inhibitors

Inhibitors on EC 2.3.1.16 - acetyl-CoA C-acyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R',4S',6R')-(+)-2-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide
-
selective over other human ELOVL sub-types, good microsomal stability
(1R',4S',6R')-(+/-)-2-(butylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide
-
racemic mixture of endo-isomers, the exo isomers are inactive
(1R',4S',6R')-(+/-)-2-(phenylsulfonyl)-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide
-
racemic mixture of endo-isomers, the exo isomers are inactive
(1R',4S',6R')-(+/-)-N-[4-(propan-2-yloxy)phenyl]-2-(thiophen-3-ylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide
-
racemic mixture of endo-isomers, the exo isomers are inactive
3-(phenylsulfonyl)-N-[4-(propan-2-yl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamide
-
-
3-oxooctanoyl-CoA
-
-
3-[1-(4-chlorophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
-
-
4-Bromo-2-octenoic acid
-
-
4-fluoro-N-[[2-oxo-6-(1H-pyrazol-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl]benzamide
-
4-fluoro-N-[[2-oxo-6-(1H-pyrazol-4-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl]benzamide
-
4-fluoro-N-[[2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl]benzamide
the S-isomer shows potent and selective inhibitory activity toward human ELOVL6
4-[4-[6,6-dimethyl-2,4-dioxo-1-phenyl-3-(trifluoromethyl)-2,3,4,5,6,7-hexahydro-1H-indol-3-yl]-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-1-yl]benzonitrile
-
-
6,6-dimethyl-3-(5-methyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
-
-
6,6-dimethyl-3-[5-methyl-1-(4-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
-
-
6,6-dimethyl-3-[5-methyl-3-oxo-1-[4-(propan-2-yl)phenyl]-2,3-dihydro-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
-
-
6,6-dimethyl-3-[5-methyl-3-oxo-1-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
acetoacetyl-CoA
acetyl-CoA
anti-thiolase-antibody
-
-
-
cycloate
-
treatment increases the content of alkylresorcinols biosynthesised in rye in both green and etiolated plants. The presence of cycloate also affects patterns of alkylresorcinol homologues in plants grown at 15°C and 22°C, very-long-side-chain compounds are less abundant, whereas both short-chain saturated and unsaturated homologues are generally accumulated. No cycloate-related effects caused by homologue pattern modifications are observed at elevated temperature
cystamine
10 mM, inactivation with half-life of 0.6 h
decanoyl-CoA
-
-
iodoacetamide
-
-
long-chain 3-oxoacyl-CoA compounds
-
-
Mg2+
-
25 mM, 20% inhibition
N-(4-methylphenyl)-3-(phenylsulfonyl)-8-azabicyclo[3.2.1]octane-8-carboxamide
-
lead compound
N-ethylmaleimide
N-Methylmaleimide
-
-
N-[4-(1,1-difluoroethyl)phenyl]-3-(phenylsulfonyl)-8-azabicyclo[3.2.1]octane-8-carboxamide
-
-
N-[4-(1,1-difluoroethyl)phenyl]-3-(pyridin-2-ylsulfonyl)-8-azabicyclo[3.2.1]octane-8-carboxamide
-
excellent selectivity over the other human ELOVL subtypes, with IC50 above 5 microM for ELOVL1, -2, -3, and -5, selective against the hERG K+ channel
N-[[6-chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl]-4-fluorobenzamide
-
NEM
-
inhibition at 1 mM in absence or presence of 0.5 mM acetyl-CoA
palmitoyl-CoA
-
up to 0.03 mM
ranolazine
-
-
Semicarbazide
-
-
trimetazidine
-
-
Tris(hydroxymethyl)aminomethane
-
-
additional information
-