2.3.1.16: acetyl-CoA C-acyltransferase

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For detailed information about acetyl-CoA C-acyltransferase, go to the full flat file.

Reaction

Synonyms

2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase, 3-KAT, 3-ketoacyl CoA thiolase, 3-ketoacyl coenzyme A thiolase, 3-ketoacyl coenzyme-A thiolase, 3-ketoacyl thiolase, 3-ketoacyl-CoA thiolase, 3-ketothiolase, 3-oxoacyl-CoA thiolase, 3-oxoacyl-coenzyme A thiolase, 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase, 6-oxoacyl-CoA thiolase, ACAA2, acetoacetyl-CoA beta-ketothiolase, acetyl-CoA acyltransferase, acyl-CoA-thiolase, acyltransferase, acetyl coenzyme A, beta-ketoacyl coenzyme A thiolase, beta-ketoacyl-CoA thiolase, beta-ketoadipyl coenzyme A thiolase, beta-ketoadipyl-CoA thiolase, beta-ketothiolase, BktB, ELo1, Elovl-5, Elovl-6, ELOVL5, Elovl6, enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein, FadA, fatty acid elongase 5, KAT, KAT-1, KAT2, ketoacyl-CoA acyltransferase, ketoacyl-coenzyme A thiolase, long-chain 3-oxoacyl-CoA thiolase, mitochondrial 3-ketoacyl-CoA thiolase, oxoacyl-coenzyme A thiolase, PaaJ, pro-3-ketoacyl-CoA thiolase, PUFA elongase, SCP2/3-oxoacyl-CoA thiolase, SCPx, sterol carrier protein 2/3-oxoacyl-CoA thiolase, TFE-beta subunit, Thb, thiloase B, thiolase A, thiolase I, thiolase II, thiolase III

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.16 acetyl-CoA C-acyltransferase

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Results	in table
3	Activating Compound
28519	AA Sequence
5	Application
1	CAS Registry Number
16	Cloned(Commentary)
2	Cofactor
8	Crystallization (Commentary)
858	Disease/ Diagnostics
2	Expression
14	General Information
3	General Stability
18	IC50 Value
47	Inhibitors
4	Ki Value [mM]
43	KM Value [mM]
41	Localization
2	Metals/Ions
38	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
170	Organism
70	Pathway
113	PDB ID
11	pH Optimum
3	pH Range
3	pH Stability
1	pI Value
3	Posttranslational Modification
9	Protein Variants
29	Purification (Commentary)
25	Reaction
4	Reaction Type
80	Reference
1	Renatured (Commentary)
70	Source Tissue
24	Specific Activity [micromol/min/mg]
8	Storage Stability
172	Substrates and Products (Substrate)
30	Subunits
70	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
8	Temperature Stability [°C]
3	Turnover Number [1/s]

Application

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Application on EC 2.3.1.16 - acetyl-CoA C-acyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

agriculture

Ovis aries

G3CH53

a single nucleotide substitution, a T to C transition located in the 3' untranslated region of the ACAA2 gene is significantly associated with total lactation production and milk protein percentage, with respective additive effects of 6.81 kg and -0.05%. A significant dominance effect of 0.46 kg is detected for milk fat yield. Homozygous TT and heterozygous CT animals exhibit higher milk yield compared with homozygous CC animals. mRNA expression of the ACAA2 gene from TT animals is 2.8- and 11.8fold higher in liver and mammary gland, respectively. The T allele is expressed at an average of 18% more compared with the C allele in the udder of randomly selected ewes

757312

medicine

2 entries

synthesis

2 entries

medicine

Saccharomyces cerevisiae

-

mutation in the thiolase gene causes severe health problems, such as ketoacidic attacks at the age of six months followed by severe retardation

486431

medicine

Homo sapiens

-

3-ketoacyl coenzyme-A thiolase inhibition could be a treatment for patients with heart failure

686251

synthesis

Cupriavidus necator

Q0KBP1

engineering of Escherichia coli for direct and modulated biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer. An Escherichia coli strain with an activated sleeping beauty mutase (Sbm) operon is used to generate propionyl-CoA as a precursor. Two acetyl-CoA moieties or acetyl-CoA and propionyl-CoA are condensed to form acetoacetyl-CoA and 3-ketovaleryl-CoA, respectively, by functional expression of beta-ketothiolases from Cupriavidus necator (i.e. PhaA and BktB). The resulting thioester intermediates are channeled into the polyhydroxyalkanoate biosynthetic pathway through functional expression of acetoacetyl-CoA reductase (PhaB) for thioester reduction and PHA synthase (PhaC) for subsequent polymerization. High-level poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer production ranging from 3 to 19 mol%, can be achieved

758384

synthesis

Cupriavidus necator ATCC 17699

-

engineering of Escherichia coli for direct and modulated biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer. An Escherichia coli strain with an activated sleeping beauty mutase (Sbm) operon is used to generate propionyl-CoA as a precursor. Two acetyl-CoA moieties or acetyl-CoA and propionyl-CoA are condensed to form acetoacetyl-CoA and 3-ketovaleryl-CoA, respectively, by functional expression of beta-ketothiolases from Cupriavidus necator (i.e. PhaA and BktB). The resulting thioester intermediates are channeled into the polyhydroxyalkanoate biosynthetic pathway through functional expression of acetoacetyl-CoA reductase (PhaB) for thioester reduction and PHA synthase (PhaC) for subsequent polymerization. High-level poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer production ranging from 3 to 19 mol%, can be achieved

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