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Literature summary for 2.3.1.16 extracted from

  • Mathieu, M.; Zeelen, J.P.; Pauptit, R.A.; Erdmann, R.; Kunau, W.H.; Wierenga, R.K.
    The 2.8 ANG. crystal structure of peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: a five-layered alpha,beta,alpha,beta,alpha structure constructed from two core domains of identical topology (1994), Structure, 2, 797-808.
    View publication on PubMed
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Application

Application Comment Organism
medicine mutation in the thiolase gene causes severe health problems, such as ketoacidic attacks at the age of six months followed by severe retardation Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol enzyme is synthesized in the cytosol and subsequently imported into the peroxisome Saccharomyces cerevisiae 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CoA + 3-oxoacyl-CoA Saccharomyces cerevisiae enzyme catalyses the last step in the beta-oxidation cycle acyl-CoA + acetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA + 3-oxoacyl-CoA
-
 Saccharomyces cerevisiae acyl-CoA + acetyl-CoA
-
 ?
CoA + 3-oxoacyl-CoA enzyme catalyses the last step in the beta-oxidation cycle Saccharomyces cerevisiae acyl-CoA + acetyl-CoA
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Saccharomyces cerevisiae