2.3.1.16: acetyl-CoA C-acyltransferase

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For detailed information about acetyl-CoA C-acyltransferase, go to the full flat file.

Reaction

Synonyms

2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase, 3-KAT, 3-ketoacyl CoA thiolase, 3-ketoacyl coenzyme A thiolase, 3-ketoacyl coenzyme-A thiolase, 3-ketoacyl thiolase, 3-ketoacyl-CoA thiolase, 3-ketothiolase, 3-oxoacyl-CoA thiolase, 3-oxoacyl-coenzyme A thiolase, 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase, 6-oxoacyl-CoA thiolase, ACAA2, acetoacetyl-CoA beta-ketothiolase, acetyl-CoA acyltransferase, acyl-CoA-thiolase, acyltransferase, acetyl coenzyme A, beta-ketoacyl coenzyme A thiolase, beta-ketoacyl-CoA thiolase, beta-ketoadipyl coenzyme A thiolase, beta-ketoadipyl-CoA thiolase, beta-ketothiolase, BktB, ELo1, Elovl-5, Elovl-6, ELOVL5, Elovl6, enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein, FadA, fatty acid elongase 5, KAT, KAT-1, KAT2, ketoacyl-CoA acyltransferase, ketoacyl-coenzyme A thiolase, long-chain 3-oxoacyl-CoA thiolase, mitochondrial 3-ketoacyl-CoA thiolase, oxoacyl-coenzyme A thiolase, PaaJ, pro-3-ketoacyl-CoA thiolase, PUFA elongase, SCP2/3-oxoacyl-CoA thiolase, SCPx, sterol carrier protein 2/3-oxoacyl-CoA thiolase, TFE-beta subunit, Thb, thiloase B, thiolase A, thiolase I, thiolase II, thiolase III

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.16 acetyl-CoA C-acyltransferase

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Results	in table
3	Activating Compound
28519	AA Sequence
5	Application
1	CAS Registry Number
16	Cloned(Commentary)
2	Cofactor
8	Crystallization (Commentary)
858	Disease/ Diagnostics
2	Expression
14	General Information
3	General Stability
18	IC50 Value
47	Inhibitors
4	Ki Value [mM]
43	KM Value [mM]
41	Localization
2	Metals/Ions
38	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
170	Organism
70	Pathway
113	PDB ID
11	pH Optimum
3	pH Range
3	pH Stability
1	pI Value
3	Posttranslational Modification
9	Protein Variants
29	Purification (Commentary)
25	Reaction
4	Reaction Type
80	Reference
1	Renatured (Commentary)
70	Source Tissue
24	Specific Activity [micromol/min/mg]
8	Storage Stability
172	Substrates and Products (Substrate)
30	Subunits
70	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
8	Temperature Stability [°C]
3	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 2.3.1.16 - acetyl-CoA C-acyltransferase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-20°C, 50% glycerol, stable

Saccharomyces cerevisiae

-

288675

-20°C, glycerol, several weeks

Bos taurus

-

486403

-76°C, 0.2 M potassium phosphate, pH 6.6, 25% v/v glycerol, 10 mM 2-mercaptoethanol, stable for months

Escherichia coli

-

2962

-80°C, wild-type and mutant enzymes H352E, H352A, H352K and H352Y, stable for at least 3 months

Rattus norvegicus

-

660434

25°C, 0.75 M Tris-HCl, pH 8.1, 25% v/v glycerol, 10 mM 2-mercaptoethanol, stable for days

Sus scrofa

-

486404

frequent freeze and thaw results in a gradual loss of activity

Saccharomyces cerevisiae

-

288675

in the absence of both cystamine and cysteamine isoform KAT2 spontaneously inactivates with a half-life

Arabidopsis thaliana

Q56WD9

719874

of 2.6 h

Arabidopsis thaliana

Q56WD9

719874