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2.1.1.77: protein-L-isoaspartate(D-aspartate) O-methyltransferase

This is an abbreviated version!
For detailed information about protein-L-isoaspartate(D-aspartate) O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.77

Reaction

S-adenosyl-L-methionine
+
protein L-isoaspartate
=
S-adenosyl-L-homocysteine
 +
protein L-isoaspartate alpha-methyl ester

Synonyms

chaperone protein L-isoaspartate (D-aspartyl) O-methyltransferase, D-aspartyl/L-isoaspartyl methyltransferase, EC 2.1.1.24, HPIMT, IAMT, isoaspartyl peptide methyltransferase, isoaspartyl protein carboxyl-O-methyltransferase, L-aspartyl/L-isoaspartyl protein methyltransferase, L-IAMT, L-isoaspartate O-methyltransferase, L-isoaspartyl (D-aspartyl) methyltransferase, L-isoaspartyl (D-aspartyl) O-methyltransferase, L-isoaspartyl methyltransferase, L-isoaspartyl O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, L-isoaspartyl-O-methyltransferase, L-isoaspartyl/D-aspartyl O-methyltransferase, L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase, methyltransferase, protein (D-aspartate), PCM, PCM-1, PCMT, PCMT1, PIMT, PIMT1, PIMT2, PIMT2 TISIalphaomega, PIMT2 TISIalphapsi, PIMT2 TISIbetapsi, PIMT2 TISIIalphaomega, PIMT2 TISIIalphapsi, PIMT2 TISIIbetapsi, PIMT2 TISIIIalphaomega, PIMT2 TISIIIalphapsi, PIMT2 TISIIIbetapsi, PIMT2', protein (L-isoaspartate) O-methyltransferase, protein carboxyl methyltransferase type II, protein D-aspartate methyltransferase, protein isoaspartate methyl transferase, protein isoaspartate methyltransferase, protein isoaspartyl carboxyl O-methyltransferase, protein isoaspartyl methyltransferase, protein isoaspartyl methyltransferase 1, protein L-isoaspartate (D-aspartate) O-methyltransferase, protein L-isoaspartate methyltransferase, protein L-isoaspartate O-methyltransferase, protein L-isoaspartate-O-methyltransferase, protein L-isoaspartyl (D-aspartate) O-methyltransferase, protein L-isoaspartyl (D-aspartyl) methyltransferase, protein L-isoaspartyl (D-aspartyl) O-methyltransferase, protein L-isoaspartyl methyl transferase, protein L-isoaspartyl methyltransferase, protein L-isoaspartyl methyltransferase1, protein L-isoaspartyl methyltransferase2, protein L-isoaspartyl O-methyltransferase, protein L-isoaspartyl-O-methyltransferase, protein L-isoaspartyl/D-aspartyl O-methyltransferase, protein repair L-isoaspartyl methyltransferase, protein repair L-isoaspartyl methyltransferase 1, protein-beta-aspartate O-methyltransferase, protein-L-isoaspartate (D-aspartate) O-methyltransferase, protein-L-isoaspartate methyltransferase, protein-L-isoaspartate O-methyltransferase, protein-L-isoaspartyl methyltransferase, RPA0376, RPA2838, StoPIMT, type II methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase

Source Tissue

Source Tissue on EC 2.1.1.77 - protein-L-isoaspartate(D-aspartate) O-methyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
69% reduced PIMT expression as compared to normal brains
Manually annotated by BRENDA team
-
PIMT expression in bovine aortic endothelial cells is regulated by cell detachment and readhesion to a substratum
Manually annotated by BRENDA team
-
treatment of astrocytoma cells (U-87) with direct pharmacological GSK-3 inhibitors stimulate PIMT expression (2fold). Results demonstrate regulation of PIMT expression by GSK-3 inhibitor lithium at both the transcriptional and the translational levels. Inhibition by siRNA of GSK-3 and beta-catenin modulates expression of the PIMT in accordance with GSK-3 pharmacological inhibition. Valproic acid up-regulates phospho-GSK-3b (Ser9), beta-catenin and PIMT levels similarly to lithium
Manually annotated by BRENDA team
-
PIMT levels are regulated by cell adhesion in various cancer cell lines. The upregulation of PIMT expression could be prevented by an anti-alphavbeta3 antibody (LM609) or by a cyclic RGD peptide (XJ735) specific to integrin alphavbeta3. PIMT expression returns to the basal level when cells are replated on a substratum after detachment, though downregulation of PIMT expression could be partly prevented by the PI3K inhibitors LY294002 and wortmannin, as well as by the proteasome inhibitors MG-132, lactacystin, and beta-lactone
Manually annotated by BRENDA team
-
80% reduced PIMT expression as compared to normal brains
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
the enzyme is more prevalent in the lens cortex than the nucleus
Manually annotated by BRENDA team
-
76% reduced PIMT expression as compared to normal brain
Manually annotated by BRENDA team
-
highest expression of isoform PIMT1
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team