Application | Comment | Organism |
---|---|---|
molecular biology | betaine administration of rats prevents the ethanol-induced accumulation of isoaspartyl-containing proteins in the liver by restoring the PIMT-catalyzed protein repair reaction through normalizing the hepatocellular SAM:SAH ratios | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | livers of male Wistar rats, fed the Lieber DeCarli control, ethanol or 1% betaine-supplemented diets for 4 weeks, are processed for PIMT-related analyses. A significant increase in the accumulation of modified proteins bearing isoaspartyl residues (substrates for PIMT), in homogenate samples and various subcellular fractions of livers from ethanol-fed rats are observed. Betaine supplementation prevents this accumulation of damaged proteins. Ethanol exposure induces no changes in the PIMT enzyme activity levels as compared to controls. The accumulation of damaged proteins negatively correlates with hepatic S-adenosylmethionine to S-adenosylhomocysteine ratios | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Rattus norvegicus |
protein L-isoaspartyl methyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |