Literature summary for 2.1.1.77 extracted from

Park, J.W.; Lee, J.C.; Ha, S.W.; Bang, S.Y.; Park, E.K.; Yi, S.A.; Lee, M.G.; Kim, D.S.; Nam, K.H.; Yoo, J.H.; Kwon, S.H.; Han, J.W.
Requirement of protein L-isoaspartyl O-methyltransferase for transcriptional activation of trefoil factor 1 (TFF1) gene by estrogen receptor alpha (2012), Biochem. Biophys. Res. Commun., 420, 223-229.

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Cloned(Commentary)

Cloned (Comment)	Organism
mutant G88A is expressed in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G88A	catalytically inactive	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + protein D-aspartate	Homo sapiens	-	S-adenosyl-L-homocysteine + protein D-aspartate methyl ester	-	?
S-adenosyl-L-methionine + protein L-isoaspartate	Homo sapiens	-	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + protein D-aspartate	-	Homo sapiens	S-adenosyl-L-homocysteine + protein D-aspartate methyl ester	-	?
S-adenosyl-L-methionine + protein L-isoaspartate	-	Homo sapiens	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?

Synonyms

Synonyms	Comment	Organism
L-isoaspartyl O-methyltransferase	-	Homo sapiens
PIMT	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme acts as a co-activator for estrogen receptor alpha-mediated transcription. Over-expression of the enzyme significantly increases the levels of trefoil factor 1 mRNA in the presence or absence of beta-estradiol	Homo sapiens

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Release 2023.1 (January 2023)