Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Homo sapiens |
protein L-isoaspartyl methyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | down-regulation of PIMT by siRNA strikingly enhances phenylarsine oxide-induced reactive oxygen species | down |
Homo sapiens | 1-chloro-2,4-dinitrobenzene does not affect PIMT expression | additional information |
Homo sapiens | PIMT is about 2fold up-regulated by 0.005 mM phenylarsine oxide in U-87 human astroglioma cells, PIMT up-regulation by phenylarsine oxide is mediated by the reaction with vicinal cysteines, PIMT induction by phenylarsine oxide is dependent on formation of reactive oxygen species, PIMT induction by phenylarsine oxide is inhibited by N-acetyl-L-cysteine and diphenyleneiodonium chloride | up |
Homo sapiens | PIMT is slightly up-regulated by 0.01 mM cycloheximide | up |