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Literature summary for 2.1.1.77 extracted from

  • Fanelus, I.; Desrosiers, R.R.
    Reactive oxygen species generated by thiol-modifying phenylarsine oxide stimulate the expression of protein L-isoaspartyl methyltransferase (2008), Biochem. Biophys. Res. Commun., 371, 203-208.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-87MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate
-
Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Synonyms

Synonyms Comment Organism
PIMT
-
Homo sapiens
protein L-isoaspartyl methyltransferase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens down-regulation of PIMT by siRNA strikingly enhances phenylarsine oxide-induced reactive oxygen species down
Homo sapiens 1-chloro-2,4-dinitrobenzene does not affect PIMT expression additional information
Homo sapiens PIMT is about 2fold up-regulated by 0.005 mM phenylarsine oxide in U-87 human astroglioma cells, PIMT up-regulation by phenylarsine oxide is mediated by the reaction with vicinal cysteines, PIMT induction by phenylarsine oxide is dependent on formation of reactive oxygen species, PIMT induction by phenylarsine oxide is inhibited by N-acetyl-L-cysteine and diphenyleneiodonium chloride up
Homo sapiens PIMT is slightly up-regulated by 0.01 mM cycloheximide up