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Literature summary for 2.1.1.77 extracted from
- Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins (1999), J. Hum. Genet., 44, 275-288.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | aging research, accumulation of damaged proteins have detrimental effects over the human lifespan | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| southern blot analysis of PCR amplified genomic DNA, human chromosome contains a single gene encoding the enzyme, PCMT1, mapped to the q24-25 region of chromosome 6 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + protein L-isoaspartate | Mus musculus | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |  |
| S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | involved in the repair of age-damaged proteins, aspartyl and asparginyl residues that are susceptible to deamidation, isomerization and racemization | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| erythrocyte | - |
Mus musculus | - |
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + protein L-isoaspartate | - |
Mus musculus | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
| S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
| S-adenosyl-L-methionine + protein L-isoaspartate | involved in the repair of age-damaged proteins, aspartyl and asparginyl residues that are susceptible to deamidation, isomerization and racemization | Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PCMT1 | - |
Mus musculus |
| PCMT1 | - |
Homo sapiens |
| protein L-isoaspartate (D-aspartate) O-methyltransferase | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 50 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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