2.1.1.224: 23S rRNA (adenine2503-C8)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (adenine2503-C8)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.224
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2.1.1.224
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linezolid
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oxazolidinone
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5\'-deoxyadenosyl
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thiopeptide
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optra
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linezolid-resistant
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phenicols
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cobalamin-dependent
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phlopsa
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pleuromutilins
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nosiheptide
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5'-deoxyadenosine
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poxta
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ribosome-targeting
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cobiialamin
- 2.1.1.224
- linezolid
-
oxazolidinone
-
5\'-deoxyadenosyl
-
thiopeptide
-
optra
-
linezolid-resistant
-
phenicols
-
cobalamin-dependent
-
phlopsa
-
pleuromutilins
-
nosiheptide
- 5'-deoxyadenosine
-
poxta
-
ribosome-targeting
-
cobiialamin
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
antibiotic resistance protein, Ba Cfr, C8 adenine RNA methylase, Cd Cfr, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase, cfr(C), Cfr(E), cfr-like, Cfr-like protein, ClbA, ClbB, ClbC, EC 2.1.1.194, Ef Cfr, Pl Cfr, radical AdoMet rRNA methyltransferase, radical S-adenosylmethionine enzyme, radical S-adenosylmethionine methylase, radical-S-adenosyl-L-methionine enzyme, radical-SAM enzyme, radical-SAM rRNA methyltransferase, RS methylase
ECTree
2.1.1.224 23S rRNA (adenine2503-C8)-methyltransferaseAdvanced search results
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results (Organism
Organism on EC 2.1.1.224 - 23S rRNA (adenine2503-C8)-methyltransferase
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ORGANISM 
COMMENTARY 
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
the strain is resistant to erythromycin, chloramphenicol, clindamycin, florfenicol, linezolid, streptogramin A, and tiamulin
UniProt
gene cfr, while cfr is typically plasmid borne, in CM05 it is located on the chromosome and is coexpressed with ermB as part of the mlr operon
UniProt
the strain is resistant to erythromycin, chloramphenicol, clindamycin, florfenicol, linezolid, streptogramin A, and tiamulin
UniProt
Cfr is plasmid-encoded, the Escherichia coli JW2501-1 strain, that does not contain the RlmN MTase that normally mediates the m2A2503 modification, is used as the host for plasmids expressing the mutated Cfr proteins and isolation of total RNA. This is done to avoid the weak primer extension stop from the m2A2503 methylation that overlaps the Cfr-mediated m8A2503 stop and therefore interferes with assessment of the activity of the mutated Cfr proteins
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gene cfr, while cfr is typically plasmid borne, in CM05 it is located on the chromosome and is coexpressed with ermB as part of the mlr operon
UniProt
