2.1.1.156: glycine/sarcosine N-methyltransferase

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For detailed information about glycine/sarcosine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

glycine sarcosine dimethylglycine methyltransferase, glycine sarcosine methyltransferase, glycine sarcosine N-methyltransferase, GSDMT, Gsm, GsmA, GSMT, GSMT2, MXAN 7068

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.156 glycine/sarcosine N-methyltransferase

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Results	in table
2	Activating Compound
702	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
2	Cofactor
4	Expression
10	General Information
1	General Stability
2	IC50 Value
21	Inhibitors
24	KM Value [mM]
5	Metals/Ions
17	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
24	Organism
4	Pathway
5	PDB ID
9	pH Optimum
2	pH Range
1	pI Value
16	Protein Variants
7	Purification (Commentary)
2	Reaction
16	Reference
10	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
9	Subunits
28	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.156 - glycine/sarcosine N-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase [sarcosine(or N,N-dimethylglycine)-forming]

Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase. Differs from EC 2.1.1.20, glycine N-methyltransferase, as it can further methylate the product of the first reaction. Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction [3].