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2.1.1.156: glycine/sarcosine N-methyltransferase

This is an abbreviated version!
For detailed information about glycine/sarcosine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.156

Reaction

S-adenosyl-L-methionine
+
glycine
=
S-adenosyl-L-homocysteine
 +
sarcosine

Synonyms

glycine sarcosine dimethylglycine methyltransferase, glycine sarcosine methyltransferase, glycine sarcosine N-methyltransferase, GSDMT, Gsm, GsmA, GSMT, GSMT2, MXAN 7068

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.156 glycine/sarcosine N-methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.156 - glycine/sarcosine N-methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-chloromercuribenzoate
-
recombinant enzyme: over 95% inhibition at 1.33 mM, completely reversible by 5.3 mM DTT
acetate
80% inhibition at 250 mM, with glycine
betaine
dimethylglycine
versus glycine, 65% inhibition at 250 mM
ethanolamine
45% inhibition at 250 mM, with glycine
KCl/NaCl
-
recombinant enzyme: synergistic with betaine, 80% inhibition at 0.33 M KCl and 0.66M NaCl with glycine, and 66% inhibition at 0.33 M KCl and 0.66 M NaCl with sarcosine, overview
monomethyl ethanolamine
35% inhibition at 250 mM, with glycine
N,N-dimethylglycine
phenylalanine
10% inhibition at 250 mM, with glycine
proline
30% inhibition at 250 mM, with glycine
S-adenosyl-L-homocysteine
sarcosine
competitive inhibition, versus glycine, 70% inhibition at 250 mM
additional information
-