1.21.3.1: isopenicillin-N synthase

This is an abbreviated version!
For detailed information about isopenicillin-N synthase, go to the full flat file.

Word Map on EC 1.21.3.1

1.21.3.1

chrysogenum

acremonium

penicillium

beta-lactam

tripeptide

cephalosporium

nidulans

clavuligerus

delta-l-alpha-aminoadipoyl-l-cysteinyl-d-valine

deacetoxycephalosporin

pcbab

cephamycins

jumonjinensis

thiazolidine

cipns

lld-acv

penams

lactamdurans

non-haem

daocs

biotechnology

synthesis

pharmacology

medicine

Reaction

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

+ 2 H2O

Synonyms

IPN cyclase, IPN synthase, IPNS, isopenicillin N synthase, isopenicillin N synthase (cyclase), isopenicillin N synthetase, isopenicillin N-synthase, isopenicillin-N synthase, isopenicillin-N-synthase, More, PcbC, synthetase, isopenicillin N (9Cl)

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.3 With oxygen as acceptor

1.21.3.1 isopenicillin-N synthase

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Results	in table
32	Activating Compound
57	AA Sequence
5	Application
1	CAS Registry Number
14	Cloned(Commentary)
13	Crystallization (Commentary)
3	Expression
2	General Information
1	General Stability
52	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
11	Localization
30	Metals/Ions
4	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
93	Organism
1	Oxidation Stability
4	Pathway
45	PDB ID
3	pH Optimum
2	pH Range
51	Protein Variants
12	Purification (Commentary)
17	Reaction
32	Reaction Type
69	Reference
1	Renatured (Commentary)
1	Source Tissue
17	Specific Activity [micromol/min/mg]
123	Substrates and Products (Substrate)
6	Subunits
104	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Turnover Number [1/s]

Expression

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Expression on EC 1.21.3.1 - isopenicillin-N synthase

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a developed gene regulation model predicts the expression of this rate limiting enzyme based on glucose repression, fast decay of the mRNA encoding for the enzyme as well as the decay of the enzyme itself

Penicillium chrysogenum

714549

the quantity of the enzyme in wild type decreases drastically from 5 days fermentation when autophagy is induced

2 entries