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1.21.3.1: isopenicillin-N synthase

This is an abbreviated version!
For detailed information about isopenicillin-N synthase, go to the full flat file.

Word Map on EC 1.21.3.1

Reaction

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
+
O2
=
isopenicillin N
+ 2 H2O

Synonyms

IPN cyclase, IPN synthase, IPNS, isopenicillin N synthase, isopenicillin N synthase (cyclase), isopenicillin N synthetase, isopenicillin N-synthase, isopenicillin-N synthase, isopenicillin-N-synthase, More, PcbC, synthetase, isopenicillin N (9Cl)

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.3 With oxygen as acceptor
                1.21.3.1 isopenicillin-N synthase

Specific Activity

Specific Activity on EC 1.21.3.1 - isopenicillin-N synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000000125
-
mutant C104S, recombinant, partially purified
0.000000093
-
purified recombinant enzyme
0.000000177
-
mutant C251S, recombinant, partially purified
0.000000257
-
mutant C142S, recombinant, partially purified
0.000000276
-
mutant C37S, recombinant, partially purified
0.000000338
-
wild-type, recombinant, partially purified
0.00000224
-
mutant H49L
0.0000027
-
wild-type
0.00000664
-
purified recombinant enzyme
0.0000103
-
mutant H126L
0.0000112
-
mutant H137L
0.0000116
-
mutant H116L
0.0000127
-
mutant H64L
0.0000136
-
wild-type
0.00129
-
about, purified enzyme
additional information