1.2.3.1: aldehyde oxidase
This is an abbreviated version!
For detailed information about aldehyde oxidase, go to the full flat file.
Word Map on EC 1.2.3.1
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1.2.3.1
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xanthine
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molybdenum
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allopurinol
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oxidases
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menadione
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benzaldehyde
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abscisic
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n-oxide
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n-heterocyclic
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moco
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phthalazine
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raloxifene
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molybdenum-containing
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xanthinuria
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hydralazine
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oxidase-mediated
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drug-drug
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molybdoenzymes
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sulphite
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o6-benzylguanine
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molybdopterin
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flavin-containing
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disulfiram
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n1-methylnicotinamide
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oxypurinol
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nutrition
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medicine
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hypouricemia
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amidoxime
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oxidase-catalyzed
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pharmacology
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synthesis
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degradation
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cyp2a6
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nitroreduction
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imidacloprid
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neonicotinoids
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phenanthridine
- 1.2.3.1
- xanthine
- molybdenum
- allopurinol
- oxidases
- menadione
- benzaldehyde
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abscisic
- n-oxide
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n-heterocyclic
- moco
- phthalazine
- raloxifene
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molybdenum-containing
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xanthinuria
- hydralazine
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oxidase-mediated
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drug-drug
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molybdoenzymes
- sulphite
- o6-benzylguanine
- molybdopterin
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flavin-containing
- disulfiram
- n1-methylnicotinamide
- oxypurinol
- nutrition
- medicine
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hypouricemia
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amidoxime
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oxidase-catalyzed
- pharmacology
- synthesis
- degradation
- cyp2a6
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nitroreduction
- imidacloprid
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neonicotinoids
- phenanthridine
Reaction
Synonyms
Aao4, AHO2, aldehyde oxidase 1, aldehyde oxidase 2, aldehyde oxidase 3, aldehyde oxidase 3-like 1, aldehyde oxidase 4, aldehyde-oxygen oxidoreductase, aldehyde:oxygen oxidoreductase, ALOD, AlOx, antennae-specific aldehyde oxidase, AO, AO-alpha, AO-beta, AO-delta, AO-gamma, AO-kappa, AO1, AO2, AO3, AO4, AOH, AOH1, AOH2, AOH3, AOMM, AOR, AOX, AOX1, AOX2, AOX3, AOX4, AtraAOX2, EC 1.2.3.11, FOD, formate oxidase, IAO1, mAOX3, mouse liver aldehyde oxidase 3, quinoline oxidase, Retinal oxidase, retinene oxidase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.2.3.1 - aldehyde oxidase
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REACTION DIAGRAM
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
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four aldehyde oxidases are known that have varying affinities to abscisic aldehyde. AOdelta, endcoded by AAO3 specifically catalyses this step in rosette leaves
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?
hypoxanthine + O2 + H2O
xanthine + H2O2
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22-26% of the activity compared to purine
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?
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
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?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
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?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
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?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
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?
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
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12-13% of the activity compared to purine
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?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
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i.e. allopurinol
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?
retinal + O2 + H2O
retinoate + H2O2
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involved in vitamin A metabolism, increased activity of cells in hyperthyroidism, decreased activity of cells in hypothyroidism
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?
retinal + O2 + H2O
retinoate + H2O2
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activity is dependent on vitamin A levels of tissues
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?
?
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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additional information
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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additional information
?
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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?
additional information
?
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catalyzes the last step of indole-3-acetic acid biosynthesis. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of enzyme expression and activity may be involved in regulation of nodule development
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additional information
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the enzyme catalyzes the last step of indole-3-acetic acid biosynthesis in plants, in the root nodules. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of aldehyde oxidase expression and activity are involved in regulation of nodule development
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additional information
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enzyme may be involved in degradation of aldehyde odorant compounds such as pheromones or plants volatiles
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additional information
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enzyme may be involved in degradation of aldehyde odorant compounds such as pheromones or plants volatiles
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additional information
?
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catalyzes the last step of indole-3-acetic acid biosynthesis. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of enzyme expression and activity may be involved in regulation of nodule development
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?
additional information
?
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the enzyme catalyzes the last step of indole-3-acetic acid biosynthesis in plants, in the root nodules. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of aldehyde oxidase expression and activity are involved in regulation of nodule development
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?
additional information
?
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enzyme plays an important role in detoxification of the toxic heterocycles synthesized by certain plants
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additional information
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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?
additional information
?
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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-
?
additional information
?
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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-
?
additional information
?
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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-
?
additional information
?
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enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
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?
additional information
?
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enzyme is of interest as a source of the reactive oxygen species, hydrogen peroxide and the superoxide anion
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?
additional information
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enzyme may be involved in synthesis of reactive oxygen species during water stress
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