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1.2.3.1: aldehyde oxidase

This is an abbreviated version!
For detailed information about aldehyde oxidase, go to the full flat file.

Word Map on EC 1.2.3.1

Reaction

an aldehyde
+
H2O
 +
O2
=
a carboxylate
 +
H2O2

Synonyms

Aao4, AHO2, aldehyde oxidase 1, aldehyde oxidase 2, aldehyde oxidase 3, aldehyde oxidase 3-like 1, aldehyde oxidase 4, aldehyde-oxygen oxidoreductase, aldehyde:oxygen oxidoreductase, ALOD, AlOx, antennae-specific aldehyde oxidase, AO, AO-alpha, AO-beta, AO-delta, AO-gamma, AO-kappa, AO1, AO2, AO3, AO4, AOH, AOH1, AOH2, AOH3, AOMM, AOR, AOX, AOX1, AOX2, AOX3, AOX4, AtraAOX2, EC 1.2.3.11, FOD, formate oxidase, IAO1, mAOX3, mouse liver aldehyde oxidase 3, quinoline oxidase, Retinal oxidase, retinene oxidase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.3 With oxygen as acceptor
                1.2.3.1 aldehyde oxidase

KI Value

KI Value on EC 1.2.3.1 - aldehyde oxidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.53
1-benzyl-3-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]thiourea
-
37°C
0.148
2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
37°C
0.113
2-(methylthio)-6-nitro-3-phenyl-3,4-dihydroquinazoline
-
37°C
0.425
3,4,5-trimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.43
3,4,5-trimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.00016
3,4-Dihydroxybenzaldehyde
-
37°C, pH 7.0, inhibition of 2-hydroxybenzaldehyde oxidation
0.51
3,4-dimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.55
3,4-dimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.136
3-benzyl-2-(methylthio)-3,4-dihydroquinazolin-6-amine
-
37°C
0.109
3-benzyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline
-
37°C
0.184
3-benzyl-6-nitro-3,4-dihydroquinazoline-2-thiol
-
37°C
0.142
3-ethyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline
-
37°C
0.105
3-ethyl-6-nitro-3,4-dihydroquinazoline-2-thiol
-
37°C
0.00066
3-Hydroxy-4-methoxybenzaldehyde
-
37°C, pH 7.0, inhibition of 2-hydroxybenzaldehyde oxidation
0.00006
4'-(9-acrydinylamino)methanesulfon-m-anisidide
-
competitive inhibitor
0.0006
4'-(9-acrydinylamino)methanesulfon-o-anisidide
-
competitive inhibitor
0.52
4-bromo-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide
-
37°C
0.445
4-methoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.45
4-methoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.46
4-methyl-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.505
4-methyl-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.103
6-nitro-3-phenyl-3,4-dihydroquinazoline-2-thiol
-
37°C
0.003
9-aminoacridine
-
competitive inhibitor
0.0225
benzamidine
competitive inhibition of phthalazine-2,6-dichlorophenol indophenol reaction, pH 8.0, 37°C
0.00087 - 0.0044
beta-estradiol
0.00062 - 0.086
chlorpromazine
0.0051
clozapine
-
Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C
0.0012
domperidone
-
Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C
0.0045
ellagic acid
-
pH 7.0, 25°C
0.34
epigallocatechin gallate
-
pH 7.4, 37°C
0.00043 - 0.0036
ethinyl estradiol
0.0003 - 0.0086
menadione
0.0044
N-hydroxy-2-acetylamino-fluorene
-
noncompetitive inhibitor
2.1
N-methylnicotinamide
-
-
0.4
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine
-
37°C
0.435
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
37°C
0.37
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine
-
37°C
0.295
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
37°C
0.31
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine
-
37°C
0.31
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
37°C
0.505
N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
37°C
0.0007 - 0.018
norharmane
0.08 - 1.04
p-dimethylaminocinnamaldehyde
0.0004 - 0.0028
quercetin
0.086
quinolinic acid
-
substrate phthalazine, pH 7.0, 37°C
0.0000023 - 0.0591
raloxifene
0.00092 - 0.001
rutin
additional information
additional information
-
table of inhibitor constants for some purine and pyrazolo[3,4-d]pyrimidines as well as of various unsubstituted aglycones and some ribonucleosides of various purine analogs
-