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Literature summary for 1.2.3.1 extracted from

  • Kurosaki, M.; Demontis, S.; Barzago, M.M.; Garattini, E.; Terao, M.
    Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone (1999), Biochem. J., 341, 71-80.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
transfection into HC11 mouse mammary epithelial cell line Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ 2 Fe/S iron centres Mus musculus
Mo5+
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
x * 150000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus O54754
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
liver male liver has about 7fold higher content of enzyme than that in female, gender specific regulation in the hepatic tissue Mus musculus
-
lung
-
Mus musculus
-
spinal cord
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0028
-
female liver Mus musculus
0.0234
-
male liver Mus musculus
0.026
-
male liver treated with testosterone propionate Mus musculus
0.026
-
female liver treated with testosterone propionate Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine Mus musculus ?
-
?
phenanthridine + H2O + O2
-
Mus musculus 6-phenanthridone + H2O2
-
?

Subunits

Subunits Comment Organism
? x * 150000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
AO
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
molybdopterin
-
Mus musculus