1.2.3.1: aldehyde oxidase
This is an abbreviated version!
For detailed information about aldehyde oxidase, go to the full flat file.
Word Map on EC 1.2.3.1
-
1.2.3.1
-
xanthine
-
molybdenum
-
allopurinol
-
oxidases
-
menadione
-
benzaldehyde
-
abscisic
-
n-oxide
-
n-heterocyclic
-
moco
-
phthalazine
-
raloxifene
-
molybdenum-containing
-
xanthinuria
-
hydralazine
-
oxidase-mediated
-
drug-drug
-
molybdoenzymes
-
sulphite
-
o6-benzylguanine
-
molybdopterin
-
flavin-containing
-
disulfiram
-
n1-methylnicotinamide
-
oxypurinol
-
nutrition
-
medicine
-
hypouricemia
-
amidoxime
-
oxidase-catalyzed
-
pharmacology
-
synthesis
-
degradation
-
cyp2a6
-
nitroreduction
-
imidacloprid
-
neonicotinoids
-
phenanthridine
- 1.2.3.1
- xanthine
- molybdenum
- allopurinol
- oxidases
- menadione
- benzaldehyde
-
abscisic
- n-oxide
-
n-heterocyclic
- moco
- phthalazine
- raloxifene
-
molybdenum-containing
-
xanthinuria
- hydralazine
-
oxidase-mediated
-
drug-drug
-
molybdoenzymes
- sulphite
- o6-benzylguanine
- molybdopterin
-
flavin-containing
- disulfiram
- n1-methylnicotinamide
- oxypurinol
- nutrition
- medicine
-
hypouricemia
-
amidoxime
-
oxidase-catalyzed
- pharmacology
- synthesis
- degradation
- cyp2a6
-
nitroreduction
- imidacloprid
-
neonicotinoids
- phenanthridine
Reaction
Synonyms
Aao4, AHO2, aldehyde oxidase 1, aldehyde oxidase 2, aldehyde oxidase 3, aldehyde oxidase 3-like 1, aldehyde oxidase 4, aldehyde-oxygen oxidoreductase, aldehyde:oxygen oxidoreductase, ALOD, AlOx, antennae-specific aldehyde oxidase, AO, AO-alpha, AO-beta, AO-delta, AO-gamma, AO-kappa, AO1, AO2, AO3, AO4, AOH, AOH1, AOH2, AOH3, AOMM, AOR, AOX, AOX1, AOX2, AOX3, AOX4, AtraAOX2, EC 1.2.3.11, FOD, formate oxidase, IAO1, mAOX3, mouse liver aldehyde oxidase 3, quinoline oxidase, Retinal oxidase, retinene oxidase
ECTree
1.2.3.1 aldehyde oxidaseAdvanced search results
results (
results (KM Value
KM Value on EC 1.2.3.1 - aldehyde oxidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.007
2,6-dichlorophenolindophenol
-
as electron acceptor under aerobic conditions
0.0024 - 0.0055
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
6.7
3-hydroxypropionaldehyde
-
recombinant cell extract, expression in Klebsiella pneumoniae, pH 7.0, 37°C
0.001 - 0.022
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
0.001 - 0.0086
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
0.0024 - 0.063
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
0.038 - 0.084
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
0.0034
zoniporide
-
in 25 mM phosphate buffer at 37°C, pH not specified in the publication
additional information
additional information
further kinetic parameters of phthalazine-DCPIP reaction in the absence or presence of the inhibitors benzamidine, menadione, norharmane, and raloxifene available in the publication
-
0.0109
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
wild type enzyme, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0157
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I/R1021V/A1023Y/I1032V/G1064K/I1067M, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0244
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I/R1021V/A1023Y/I1032V, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0264
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme A1023Y, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.027
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme M1009I, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0334
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme I1032V, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.036
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0366
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0521
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0965
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I/R1021V/A1023Y, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.128
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme A1083T/V1085A, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.131
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme V1085A, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0352
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
mutant enzyme A1081V, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.147
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild type enzyme, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0341
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
pH 7.4, 37°C
0.0407
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
pH 7.4, 37°C, enzyme isolated from animals fed with a selenium-deficient diet
0.0027
(S)-RS-8359
high affinity component of the expressed enzyme
0.0804
(S)-RS-8359
pH 7.4, 37°C, enzyme from Wistar-Imamichi strain, ratio Vmax/Km 1.98 microl per min and mg
0.0813
(S)-RS-8359
pH 7.4, 37°C, enzyme from Jcl:Wistar strain, ratio Vmax/Km 1.00 microl per min and mg
0.0833
(S)-RS-8359
pH 7.4, 37°C, enzyme from Crj:Wistar strain, ratio Vmax/Km 1.46 microl per min and mg
0.1046
(S)-RS-8359
pH 7.4, 37°C, enzyme from LEW:Crj strain, ratio Vmax/Km 0.58 microl per min and mg
0.14
(S)-RS-8359
pH 7.4, 37°C, enzyme from F344/DuCrj strain, ratio Vmax/Km 0.01 microl per min and mg
0.17
(S)-RS-8359
pH 7.4, 37°C, enzyme from Slc:SD strain, ratio Vmax/Km 0.09 microl per min and mg
0.173
(S)-RS-8359
pH 7.4, 37°C, enzyme from Crj:SD strain, ratio Vmax/Km 0.06 microl per min and mg
0.0263
2,4-dihydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.097
2-hydroxypyrimidine
-
apparent Km-value of recombinant mAOX3, pH 7.4, 25°C
0.0024
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0026
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0027
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0055
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0043
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, high affinity value, pH 6.0, 37°C
0.0043
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, high affinity value, pH 6.0, 37°C
0.0164
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild-type, low affinity value, pH 6.0, 37°C
0.0171
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, low affinity value, pH 6.0, 37°C
0.0171
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, low affinity value, pH 6.0, 37°C
0.0351
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild-type, high affinity value, pH 6.0, 37°C
0.0363
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric monkey/rat enzyme, pH 6.0, 37°C
0.0363
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric monkey/rat enzyme, pH 6.0, 37°C
0.0528
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild-type, pH 6.0, 37°C
0.0008
4-(dimethylamino)cinnamaldehyde
wild-type, pH 8.0, 37°C
0.0096
4-(dimethylamino)cinnamaldehyde
-
in the presence of 1 mM nitrite, at pH 6.0 and 37°C
0.0019
4-hydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.0013
4-nitrobenzaldehyde
wild-type, pH 8.0, 37°C
0.1
5-nitroquinoline
metabolite 5-aminoquinoline, presence of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide, pH 7.4, 37°C
-
0.912
5-nitroquinoline
metabolite 2-oxo-5-nitroquinoline, presence of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide, pH 7.4, 37°C
-
0.04
6-ethyl-5H-dibenz(c,e)azepine
-
2,6-dichlorophenol-indophenol as electron acceptor in D2O
0.06
6-ethyl-5H-dibenz(c,e)azepine
-
2,6-dichlorophenol-indophenol as electron acceptor in H2O
0.3
6-methylthiopurine
-
2,6-dichlorophenol indophenol as electron acceptor
0.001
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0017
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0059
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.022
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.001
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0011
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0043
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0086
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0024
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.004
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.02
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.063
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.038
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.064
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.064
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.084
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.133
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
2.93
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
2.21
benzaldehyde
mutant F776K/A807E/D878L/L881S/Y885R/P1015T/Y1019L, pH 8.0,37°C
0.0074
cinchonidine
-
wild type enzyme, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.012
cinchonidine
-
mutant enzyme V1085A, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.08
N-methylnicotinamide
-
2,6-dichlorophenol-indophenol as electron acceptor in D2O
0.32
N-methylnicotinamide
-
2,6-dichlorophenol-indophenol as electron acceptor in H2O
0.355
N-methylnicotinamide
female rat liver enzyme after reduction with DTT
0.36
N-methylnicotinamide
male rat liver enzyme after reduction with DTT
1.895
N-methylnicotinamide
female rat liver enzyme after reduction with DTT and reoxidation with 4,4'-dithiodipyridine
0.011
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
female enzyme treated with testosterone propionate
0.0029
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, strain c129/C57
0.0055
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, nude mouse tumor bearing
0.0074
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, nude mouse
0.027
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, female swiss CD
0.03
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, male swiss CD
0.05
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, strain CB57BI/6J
3.3
nitrite
-
in the presence of 0.05 mM 4-(dimethylamino)cinnamaldehyde, at pH 6.0 and 37°C
0.0111
phenylpropionaldehyde
wild-type, pH 8.0, 37°C
0.733
Phthalazine
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.0081
Salicylaldehyde
mutant I1018K, pH 8.0, 37°C
0.0092
Salicylaldehyde
mutant I1018S, pH 8.0, 37°C
0.0136
Salicylaldehyde
mutant M1088V, pH 8.0, 37°C
0.0238
Salicylaldehyde
mutant M1088T, pH 8.0, 37°C
0.0447
Salicylaldehyde
mutant V1016I, pH 8.0, 37°C
0.0559
Salicylaldehyde
mutant V1016L, pH 8.0, 37°C
0.0158
Vanillin
-
pH 7.4, 37°C, enzyme isolated from animals fed with a selenium-deficient diet
