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1.14.18.5: sphingolipid C4-monooxygenase

This is an abbreviated version!
For detailed information about sphingolipid C4-monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.5

Reaction

a dihydroceramide
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
a (4R)-4-hydroxysphinganine ceramide
 + 2 ferricytochrome b5 +
H2O

Synonyms

bifunctional sphingolipid D4-desaturase/C4-hydroxylase, DES2, DHS hydroxylase, dihydroceramide hydrolase, dihydroceramide hydroxylase, EC 1.14.13.169, LmjF_26_1670, SBH1, SBH2, SC4H, sphinganine C4-hydroxylase, sphinganine C4-monooxygenase, sphingolipid C4-hydroxylase, sphingolipid delta(4)-desaturase/C4-monooxygenase, sphingolipid hydroxylase, SUR2, Sur2p, SYR2, Syr2p

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.5 sphingolipid C4-monooxygenase

Cloned

Cloned on EC 1.14.18.5 - sphingolipid C4-monooxygenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in a Saccaromyces cerevisiae sur2-null mutant
expressed in a Saccharomyces cerevisiae sur2v-null mutant
expressed in HEK-293 cells
expressed in Saccharomyces cerevisiae strain W303A
-
expressed in Saccharomyces cerevisiae strain Y03656
-
expression in Saccharomyces cerevisiae DELTAsur2 mutant