1.14.18.5: sphingolipid C4-monooxygenase
This is an abbreviated version!
For detailed information about sphingolipid C4-monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.5
-
1.14.18.5
-
sphingolipids
-
sphingoid
-
phytosphingosine
-
phytoceramide
-
oxygen-dependent
-
inositolphosphorylceramide
-
c4-hydroxylation
-
nidulans
-
dihydrosphingosine
- 1.14.18.5
- sphingolipids
-
sphingoid
- phytosphingosine
- phytoceramide
-
oxygen-dependent
-
inositolphosphorylceramide
-
c4-hydroxylation
- nidulans
- dihydrosphingosine
Reaction
Synonyms
bifunctional sphingolipid D4-desaturase/C4-hydroxylase, DES2, DHS hydroxylase, dihydroceramide hydrolase, dihydroceramide hydroxylase, EC 1.14.13.169, LmjF_26_1670, SBH1, SBH2, SC4H, sphinganine C4-hydroxylase, sphinganine C4-monooxygenase, sphingolipid C4-hydroxylase, sphingolipid delta(4)-desaturase/C4-monooxygenase, sphingolipid hydroxylase, SUR2, Sur2p, SYR2, Syr2p
ECTree
1.14.18.5 sphingolipid C4-monooxygenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.14.18.5 - sphingolipid C4-monooxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-erythro-eicosasphinganine + NADH + H+ + O2
4-hydroxyeicosasphinganine + NAD+ + H2O
-
-
-
-
?
D-erythro-sphinganine + NADH + H+ + O2
4-hydroxysphinganine + NAD+ + H2O
-
-
free 4-hydroxysphinganine is produced in excised corn shoots by the direct hydroxylation of sphinganine and not from the breakdown of complex sphingolipids
-
?
D-erythro-sphinganine + NADPH + H+ + O2
4-hydroxysphinganine + NADP+ + H2O
-
-
-
-
?
dihydroceramide + reduced acceptor + H+ + O2
phytoceramide + acceptor + H2O
-
-
-
?
dihydrosphingosine + NADPH + H+ + O2
phytosphingosine + NADP+ + H2O
-
-
-
?
DL-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
phytosphingosine + acceptor + H2O
N-acetylsphinganine + NADPH + H+ + O2
N-acetyl-4-hydroxysphinganine + NADP+ + H2O
-
-
-
-
?
N-hexanoylsphinganine + NADPH + H+ + O2
N-hexanoyl-4-hydroxysphinganine + NADP+ + H2O
-
-
-
-
?
N-octanoyl-D-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
?
-
-
-
?
N-octanoylsphinganine + NADPH + H+ + O2
N-octanoyl-4-hydroxysphinganine + NADP+ + H2O
-
-
-
-
?
sphinganine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+
4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O
-
plus (E)-sphing-4-enine ceramide, the (E)-sphing-4-enine/4-hydroxysphinganine ratio is 2.5:1
-
?
sphingosine + reduced acceptor + H+ + O2
phytosphingosine + acceptor + H2O
-
-
-
?
DL-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
phytosphingosine + acceptor + H2O
-
-
-
-
?
DL-erythro-dihydrosphingosine + reduced acceptor + H+ + O2
phytosphingosine + acceptor + H2O
-
-
-
-
?
sphinganine + reduced acceptor + H+ + O2
phytosphinganine + acceptor + H2O
-
-
-
?
sphinganine + reduced acceptor + H+ + O2
phytosphinganine + acceptor + H2O
-
-
-
?
additional information
?
-
enzyme is a bifunctional sphingolipid DELTA4-desaturase/C4-hydroxylase, with the desaturase activity being one order of magnitude higher than the hydroxylase activity
-
-
?
