Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
x * 35000, FLAG3-tagged enzyme, SDS-PAGE | Homo sapiens |
41200 | - |
x * 41200, estimated from amino acid sequence | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6QHC5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
additional information | not detected in heart, liver, spleen, skeletal muscle, thymus or placenta | Homo sapiens | - |
skin | highest expression in skin | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroceramide + reduced acceptor + H+ + O2 | - |
Homo sapiens | phytoceramide + acceptor + H2O | - |
? | |
N-octanoyl-D-erythro-dihydrosphingosine + reduced acceptor + H+ + O2 | - |
Homo sapiens | ? | - |
? | |
sphingosine + reduced acceptor + H+ + O2 | - |
Homo sapiens | phytosphingosine + acceptor + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 35000, FLAG3-tagged enzyme, SDS-PAGE | Homo sapiens |
? | x * 41200, estimated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DES2 | - |
Homo sapiens |
dihydroceramide hydroxylase | - |
Homo sapiens |
sphingolipid C4-hydroxylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is up-regulated during keratinocyte differentiation | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues | Homo sapiens |