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1.14.18.5: sphingolipid C4-monooxygenase

This is an abbreviated version!
For detailed information about sphingolipid C4-monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.5

Reaction

a dihydroceramide
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (4R)-4-hydroxysphinganine ceramide
+ 2 ferricytochrome b5 +
H2O

Synonyms

bifunctional sphingolipid D4-desaturase/C4-hydroxylase, DES2, DHS hydroxylase, dihydroceramide hydrolase, dihydroceramide hydroxylase, EC 1.14.13.169, LmjF_26_1670, SBH1, SBH2, SC4H, sphinganine C4-hydroxylase, sphinganine C4-monooxygenase, sphingolipid C4-hydroxylase, sphingolipid delta(4)-desaturase/C4-monooxygenase, sphingolipid hydroxylase, SUR2, Sur2p, SYR2, Syr2p

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.5 sphingolipid C4-monooxygenase

Sequence

Sequence on EC 1.14.18.5 - sphingolipid C4-monooxygenase

Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DEGS2_BOVIN
323
0
37319
Swiss-Prot
other Location (Reliability: 3)
DEGS2_CAEEL
362
3
42316
Swiss-Prot
other Location (Reliability: 3)
DEGS2_HUMAN
323
1
37197
Swiss-Prot
other Location (Reliability: 4)
SBH1_ARATH
260
3
29819
Swiss-Prot
Secretory Pathway (Reliability: 2)
SBH2_ARATH
259
3
29831
Swiss-Prot
Secretory Pathway (Reliability: 1)
DEGS2_MOUSE
323
0
37491
Swiss-Prot
other Location (Reliability: 3)
DEGS2_RAT
323
5
37441
Swiss-Prot
other Location (Reliability: 3)
A0A2Z4LT79_9FLAO
Muricauda aurantiaca
257
4
29304
TrEMBL
-
B7FLU5_MEDTR
263
1
30186
TrEMBL
other Location (Reliability: 5)
A0A5B7A8L7_DAVIN
257
3
29511
TrEMBL
Secretory Pathway (Reliability: 1)
A0A084G5A8_PSEDA
377
2
42936
TrEMBL
other Location (Reliability: 5)
A0A6J8B6B3_MYTCO
219
3
25945
TrEMBL
other Location (Reliability: 3)
A0A5B7A3E9_DAVIN
257
3
29649
TrEMBL
Secretory Pathway (Reliability: 2)
A0A396JTI8_MEDTR
140
2
16019
TrEMBL
other Location (Reliability: 2)
A0A812CFK5_SEPPH
162
2
19072
TrEMBL
Mitochondrion (Reliability: 2)
A0A2P6PAH8_ROSCH
243
2
28067
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2P6P809_ROSCH
118
0
13713
TrEMBL
other Location (Reliability: 5)
A0A2P6P811_ROSCH
275
2
31445
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2P6P827_ROSCH
139
2
15524
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2G9HHX5_9LAMI
263
3
30326
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2P6PRK1_ROSCH
260
4
29756
TrEMBL
Secretory Pathway (Reliability: 5)
A0A5B7A0U3_DAVIN
257
4
29527
TrEMBL
other Location (Reliability: 4)
A0A072VZX3_MEDTR
255
5
29296
TrEMBL
Secretory Pathway (Reliability: 5)
A0A5B7A6X4_DAVIN
257
3
29517
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2G9I2U3_9LAMI
263
1
30289
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2P6R2X2_ROSCH
257
2
29476
TrEMBL
Secretory Pathway (Reliability: 3)
A0A5B7BCE3_DAVIN
194
3
22111
TrEMBL
Secretory Pathway (Reliability: 4)
G3FCJ2_LEIMA
352
5
41124
TrEMBL
-
SUR2_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
349
0
40734
Swiss-Prot
-
Q6YGT5_WICCI
325
0
38334
TrEMBL
-