EC Number |
Protein Variants |
Reference |
---|
3.4.22.55 | K152A |
mutant enzyme with strikingly altered caspase-2 localization. Whereas caspase-2 characteristically accumulates in the nucleus forming dots or filaments, the mutant enzyme is mostly localized outside and exclusively of the nucleus forming dot-like aggregates. K152A mutants can also kill transfected cells at comparable levels to the wild-type version |
647762 |
3.4.22.55 | more |
caspase prodomain-DELTA25 mutant is slightly less effective than wild-type caspase-2, inducing cell death of about 70% of transfected cells. Caspase prodomain-DELTA25 mutant cannot kill due to its impaired nuclear localization |
647762 |
3.4.22.55 | more |
knockdown of caspase-2 and overexpression of a caspase-2 mutant |
717457 |
3.4.22.55 | S135A |
phosphorylation site |
711848 |
3.4.22.55 | S135A |
phosphorylation site, suppressed equally compared with wild type protein during mitosis |
711848 |
3.4.22.55 | S135A/S308A |
rapidly processed in mitosis compared with caspase-2 S308A mutant |
711848 |
3.4.22.55 | S139An |
expression of mutant S139A leads to significantly enhanced growth rate of cells |
732048 |
3.4.22.55 | S157A/C320A |
nonphosphorylatable, dimerizes constitutively |
664753 |
3.4.22.55 | S308A |
phosphorylation site, S308 phosphorylated in mitosis, abrogates mitotic suppression, processing of mutant S308A in mitosis does not occur immediately, but rather occurs with roughly the same kinetics as wild-type caspase-2 in interphase |
711848 |
3.4.22.55 | S340A |
phosphorylation site, expression of mutant S340A more than doubles the sensitivity of cells to nocodazole-induced mitotic death compared with wild-type protein |
711848 |