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Literature summary for 3.4.22.55 extracted from

  • Shin, S.; Lee, Y.; Kim, W.; Ko, H.; Choi, H.; Kim, K.
    Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8 (2005), EMBO J., 24, 3532-3542.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.55

Activating Compound

Activating Compound Comment Organism Structure
additional information when protein kinase CK2 activity is low, procaspase-2 is dephosphorylated, dimerized, and activated in a PIDDosome-independent manner Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
C320A forms a dimer only when cell are treated with DRB Homo sapiens
S157A/C320A nonphosphorylatable, dimerizes constitutively Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
protein kinase CK2 phosphorylates procaspase-2 directly at serine-157. When protein kinase CK2 activity is low, procaspase-2 is dephosphorylated, dimerized, and activated in a PIDDosome-independent manner Homo sapiens
Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH2F
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P42575
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCE-4 cell human esophageal cancer cell line Homo sapiens
-
HCE-7 cell human esophageal cancer cell line Homo sapiens
-
HCT-116 cell human colon cancer cell line Homo sapiens
-
LN-319 cell human malignant glioma cell line Homo sapiens
-
SW-480 cell human colon cancer cell line Homo sapiens
-
TE-2 cell human esophageal cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procaspase-8 + H2O processing occurs between the large and small subunits Homo sapiens processed procaspase-8 p43/41 form ?

Subunits

Subunits Comment Organism
dimer active form, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
caspase-2
-
 Homo sapiens