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Literature summary for 3.4.22.55 extracted from

  • Sohn, D.; Budach, W.; Jaenicke, R.U.
    Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1) (2011), Cell Death Differ., 18, 1664-1674.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information the topoisomerase-II inhibitor etoposide induces processing of procaspase-2 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of caspase-2 and overexpression of a caspase-2 mutant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the topoisomerase-II inhibitor etoposide induces processing of procaspase-2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
malfunction depletion of caspase-2 prevents p21 expression and thereby reverts the gamma-IR-induced senescent phenotype of wild-type HCT116 colon carcinoma cells into apoptosis, knockdown of none of the caspase-2-interacting components RAIDD, RIP or DNA-PKcs is able to mimic these processes, but knockdown of caspase-2 specifically impairs DNA damage-induced p21 expression, and silencing of caspase-2 impairs exogenous expression of p21 constructs containing 3'-UTR sequences, whereas overexpression of a caspase-2 mutant increases p21 levels. Silencing of caspase-2 impairs exogenous expression of p21 constructs containing 3'-UTR sequences Homo sapiens
physiological function caspase-2 is commonly required for DNA damage-induced p21 expression. Caspase-2 regulates p21 expression at the translational level, independently of its enzymatic activity but also not requiring known caspase-2-activating platforms Homo sapiens