EC Number   |
General Information |
Reference |
|---|
   3.4.22.57 | evolution |
caspase-4 is a member of the caspase family |
717945 |
| 3.4.22.57 | evolution |
caspase-4 is a member of the caspase family and a member of the interleukin-1beta coverting enzyme subfamily |
718292 |
| 3.4.22.57 | evolution |
caspase-4 is a member of the caspase-1 family |
718027 |
| 3.4.22.57 | malfunction |
overexpression of wild-type caspase-4 results in cytotoxicity, reflected by slightly enhanced amounts of beta-actin in the supernatant |
717945 |
| 3.4.22.57 | malfunction |
when caspase-4 activity is blocked by the dominant negative form of nuclear factor-kappaB, Fas-induced cell death is substantially reduced |
732677 |
| 3.4.22.57 | more |
elevated caspase activity in Pt1 cells is an outcome of increased caspase-4 activation |
718292 |
| 3.4.22.57 | physiological function |
acute inflammatory cell death in the intestinal tract is mediated by caspase-4 |
731612 |
| 3.4.22.57 | physiological function |
caspase-4 activity is required for Fas-induced cell apoptosis |
732677 |
| 3.4.22.57 | physiological function |
caspase-4 and caspase-5 are the key determinants of one-step inflammasome activation in human monocyte. The contribute to TLR4-mediated IL-1alpha/beta release from human monocytes |
754835 |
| 3.4.22.57 | physiological function |
caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells, interaction between caspase-4 and caspase-9 in endoplasmic reticulum stress-induced apoptosis, overview |
718027 |
