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Literature summary for 3.4.22.57 extracted from

  • Yamamuro, A.; Kishino, T.; Ohshima, Y.; Yoshioka, Y.; Kimura, T.; Kasai, A.; Maeda, S.
    Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells (2011), J. Pharmacol. Sci., 115, 239-243.
    View publication on PubMed
Search for more literature for 3.4.22.57

Activating Compound

Activating Compound Comment Organism Structure
tunicamycin activates caspase-4. Activation of caspase-4 preceeds that of caspase-9 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LEVD-CHO a caspase-4 inhibitor, suppresses both the apoptosis and caspase-9 activation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procaspase-9 + H2O Homo sapiens
-
 caspase-9 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification tunicamycin and thapsigargin induce caspase-4 mRNA expression and protein activation, cleavage of caspase-4 is not affected by overexpression of Bcl-2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procaspase-9 + H2O
-
 Homo sapiens caspase-9 + ?
-
 ?
procaspase-9 + H2O human recombinant active caspase-4 cleaves wild-type and D330A mutant caspase-9 at residue D315, but not the D315A mutant Homo sapiens caspase-9 + ?
-
 ?

Expression

Organism Comment Expression
Homo sapiens tunicamycin and thapsigargin induce caspase-4 mRNA expression and protein activation up

General Information

General Information Comment Organism
evolution caspase-4 is a member of the caspase-1 family Homo sapiens
physiological function caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells, interaction between caspase-4 and caspase-9 in endoplasmic reticulum stress-induced apoptosis, overview Homo sapiens