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Literature summary for 3.4.22.57 extracted from

  • Yang, H.J.; Wang, M.; Wang, L.; Cheng, B.F.; Lin, X.Y.; Feng, Z.W.
    NF-kappaB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis (2015), PLoS ONE, 10, e0117953.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.57

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 x * 35000, active enzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-EP1 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 35000, active enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Cas4
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the dominant negative form of IkappaBalpha suppresses the expression of caspase-4 down
Homo sapiens enhancement of nuclear factor-kappaB activity by p65 (RelA) overexpression increases the expression of caspase-4 at both mRNA and protein levels up

General Information

General Information Comment Organism
malfunction when caspase-4 activity is blocked by the dominant negative form of nuclear factor-kappaB, Fas-induced cell death is substantially reduced Homo sapiens
physiological function caspase-4 activity is required for Fas-induced cell apoptosis Homo sapiens