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Information on EC 3.4.22.57 - caspase-4

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.57 caspase-4
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Word Map
  • 3.4.22.57
  • chop
  • inflammasome
  • pyroptosis
  • stress-mediated
  • caspase-5
  • glucose-regulated
  • perk
  • gadd153
  • gasdermin
  • stress-associated
  • salubrinal
  • pkr-like
  • pyrin
  • eif2alpha
  • gsdmd
  • speck-like
  • inositol-requiring
  • medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/-
Synonyms
casp4, caspase 4, casp-4, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/-
show the reaction diagram
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