Application | Comment | Organism |
---|---|---|
medicine | caspase-4 represents a target for the treatment of (auto)inflammatory diseases | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type, native caspase-4, of C-terminal Myc-tagged wild-type vcaspase-4, and of caspase-4 mutant C285A in COS-1 cells, co-expression with caspase-1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown expression of caspase-4 with siRNA in keratinocytes, overexpression of active caspase-4 rescues UVB-induced secretion of IL-1b by caspase-4 knockdown keratinocytes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-LEVD-fluoromethylketone | caspase-4, -5, and -1 inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-4 physically interacts with its central molecule caspase-1 | ? | - |
? | |
procaspase-1 + H2O | Homo sapiens | caspase-4 processes caspase-1 and enhances secretion of IL-1beta in transfected COS-1 cells | caspase-1 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | skin-derived | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-4 physically interacts with its central molecule caspase-1 | Homo sapiens | ? | - |
? | |
procaspase-1 + H2O | - |
Homo sapiens | caspase-1 + ? | - |
? | |
procaspase-1 + H2O | caspase-4 processes caspase-1 and enhances secretion of IL-1beta in transfected COS-1 cells | Homo sapiens | caspase-1 + ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | caspase-4 protein expression is strongly induced in the lesional stratum corneum of patients suffering from psoriasis, a common chronic inflammatory disease | up |
General Information | Comment | Organism |
---|---|---|
evolution | caspase-4 is a member of the caspase family | Homo sapiens |
malfunction | overexpression of wild-type caspase-4 results in cytotoxicity, reflected by slightly enhanced amounts of beta-actin in the supernatant | Homo sapiens |
physiological function | caspase-4 is involved in endoplasmic reticulum stress-induced apoptosis and is required for activation of inflammasomes. Caspase-4 expression is required for UVB-induced activation of proIL-1beta and for unconventional protein secretion by skin-derived keratinocytes, requiring expression of the nucleotide-binding domain leucine-rich repeat containing, Pyrin domain containing-3 inflammasome. Caspase-4 supports activation of caspase-1 and proIL-1beta processing in COS-1 cells | Homo sapiens |