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Literature summary for 3.4.22.57 extracted from

  • Sollberger, G.; Strittmatter, G.E.; Kistowska, M.; French, L.E.; Beer, H.D.
    Caspase-4 is required for activation of inflammasomes (2012), J. Immunol., 188, 1992-2000.
    View publication on PubMed

Application

Application Comment Organism
medicine caspase-4 represents a target for the treatment of (auto)inflammatory diseases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type, native caspase-4, of C-terminal Myc-tagged wild-type vcaspase-4, and of caspase-4 mutant C285A in COS-1 cells, co-expression with caspase-1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown expression of caspase-4 with siRNA in keratinocytes, overexpression of active caspase-4 rescues UVB-induced secretion of IL-1b by caspase-4 knockdown keratinocytes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-LEVD-fluoromethylketone caspase-4, -5, and -1 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-4 physically interacts with its central molecule caspase-1 ?
-
?
procaspase-1 + H2O Homo sapiens caspase-4 processes caspase-1 and enhances secretion of IL-1beta in transfected COS-1 cells caspase-1 + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte skin-derived Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-4 physically interacts with its central molecule caspase-1 Homo sapiens ?
-
?
procaspase-1 + H2O
-
Homo sapiens caspase-1 + ?
-
?
procaspase-1 + H2O caspase-4 processes caspase-1 and enhances secretion of IL-1beta in transfected COS-1 cells Homo sapiens caspase-1 + ?
-
?

Expression

Organism Comment Expression
Homo sapiens caspase-4 protein expression is strongly induced in the lesional stratum corneum of patients suffering from psoriasis, a common chronic inflammatory disease up

General Information

General Information Comment Organism
evolution caspase-4 is a member of the caspase family Homo sapiens
malfunction overexpression of wild-type caspase-4 results in cytotoxicity, reflected by slightly enhanced amounts of beta-actin in the supernatant Homo sapiens
physiological function caspase-4 is involved in endoplasmic reticulum stress-induced apoptosis and is required for activation of inflammasomes. Caspase-4 expression is required for UVB-induced activation of proIL-1beta and for unconventional protein secretion by skin-derived keratinocytes, requiring expression of the nucleotide-binding domain leucine-rich repeat containing, Pyrin domain containing-3 inflammasome. Caspase-4 supports activation of caspase-1 and proIL-1beta processing in COS-1 cells Homo sapiens